Abstract
The study of enzyme activities in trophoblastic cells is important for several reasons. From a biological point of view, it provides informations about the activation of specific metabolic pathways. For practical purposes, a knowledge of the normal range of enzyme levels makes possible the first trimester fetal diagnosis of metabolic diseases in pregnancies at risk (Kazy et al. 1982; Danesino 1983; Simoni et al. 1983). In this respect, the most consistent data obtained so far concern the activity of lysosomal enzymes. So far, prenatal diagnosis through the technique of chorionic villi sampling (CVS) has been realized in about 100 pregnancies at risk for lysosomal diseases (see Galjaard, this volume).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beutler E (1975) Red cell metabolism. A manual of biochemical methods. Grune and Stratton, New York
Danesino C (1983) Enzyme determinations on chorionic villi in the first trimester of pregnancy for prenatal diagnosis of metabolic diseases. In: Albertini A, Crosignani PG (eds) Progress in perinatal medicine. Excerpta Medica, Amsterdam, pp 293–301
Di Ilio C, Polidoro G, Arduini A, Muccini A, Federici G (1983) Glutathione peroxidase, glutathione reductase, glutathione S-transferase and γ-glutamiltranspeptidase activities in the human early pregnancy placenta. Biochem Med 29: 143–148
Kazy Z, Rozovsky IS, Bakharen VA (1982) Chorion biopsy in early pregnancy: a method of early prenatal diagnosis for inherited disorders. Prenat Diagn 2: 39–45
Lowry OH, Rosebrough NJ, Farr A, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265–275
Pratt OE (1980) The fetal alcohol syndrome: transport of nutrients and transfer of alcohol and acetaldehyde from mother to fetus. In: Sandler M (ed) Psychopharmacology of alcohol. Raven, New York, pp 229–263
Simoni G, Brambati B, Danesino C, Rossella F, Terzoli GL, Ferrari M, Fraccaro M (1983) Efficient direct chromosome analyses and enzyme determinations from chorionic villi samples in the first trimester of pregnancy. Hum Genet 63: 349–357
Yoshida A (1984) Determination of aldehyde dehydrogenase phenotypes using hair roots: re-examination. Hum Genet 66: 296–299
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Dallapiccola, B., Novelli, G., Palloni, R., Catizone, F., Magnani, M. (1985). Activity of 30 Nonlysosomal Enzymes in Chorionic Villi. In: Fraccaro, M., Simoni, G., Brambati, B. (eds) First Trimester Fetal Diagnosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70707-0_37
Download citation
DOI: https://doi.org/10.1007/978-3-642-70707-0_37
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-15785-4
Online ISBN: 978-3-642-70707-0
eBook Packages: Springer Book Archive