Abstract
It has been known for some time that various substrains of BALB/c, while all originally derived from the same breeding stock, differ phenotypically and at several distinct genetic loci (Potter this volume). In particular, a single difference has been described in the MHC locus on chromosome 17. BALB/cJ mice and all sublines derived from them are Qa2a, that is, they express the epitope identified by B6.K1 anti B6 antiserum. BALB/cAn mice and most sublines derived from them are Qa2b and do not express the epitope (Forman 1978). Recently, a single 3.7 kilobase (KB) XbaI restriction fragment has ben identified that distinguishes these two BALB/c sublines, and convincing evidence has been presented that this correlates with Qa2 phenotype. In fact, it seems likely that the fragment is part of the gene encoding the Qa2 molecule (Flaherty 1985).
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References
Flaherty L, DiBiase K, Lynes MA, Seidman JG, Weinberger O, Rinchik EM (1985) Characterization of a Q subregion gene in the murine major histocompatibility complex. Proc Natl Acad Sci USA 82:1503–1507
Forman J, Flaherty L (1978) Identification of a new CML target antigen controlled by a gene associated with the Qa-2 locus. Immunogenet 6:227–237
Malissen M, Damotte M, Birnbaum D, Tracy J, Jordan BR (1982) HLA cosmid clones show complete, widely spaced class I genes with occasional clusters and restriction enzyme polymorphism. Gene 20:485–493
Margulies DH, Evans GA, Flaherty L, Seidman JG (1982) H-2 like genes in the Tla region of mouse chromosome 17. Nature 295:168–170
Meschini A, Invernizzi G, Parmiani G (1977) Expression of alien H-2 antigens on a chemically induced BALB/c fibrosarcoma. Int J Cancer 20:271–283
Potter M, Wax JS (1981) Genetics of susceptibility to pristane- induced plasmacytomas in BALB/cAn: reduced susceptibility in BALB/cJ with a brief description of pristane-induced arthritis. J Immunol 127:1591–1595
Prat M, Rogers MJ, Appella E (1978) Alloantisera reacting with tumor cells of inappropriate haplotype. 1. Characterization of target antigens. J Natl Cancer Inst 61:527–534
Rogers MJ, Germain RN, Hare J, Long E, Singer DS (1985) Comparison of MHC genes among distantly related members of the genus Mus. J Immunol 134:630–636
Rogers MJ, Gooding LR, Margulies DH, Evans GA (1983) Analysis of a defect in the H-2 genes of SV40 transformed C3H fibroblasts that do not express H-2Kb. J Immunol 130:2418–2422
Rogers MJ, Law LW, Pierotti MA, Parmiani G (1980) Separation of the TATA from the alien H-2k antigens expressed on a methylcholanthene-induced tumor. Int J Cancer 25:105–109
Singer DS, Camerini-Otero RD, Satz ML, Osborne B, Sachs D, Rudikoff S (1982) Characterization of a porcine genomic clone encoding a major histocompatibility antigen: expression in mouse L cells. Proc Natl Acad Sci USA 79:1403–1408
Weiss EH, Golden L, Fahrner K, Mellor AL, Devlin JJ, Bullman H, Tiddens H, Buel H, Flavell RA (1984) Organization and evolution of the class I gene family in the MHC of the C57B1/10 mouse. Nature 310:650–655
Winoto A, Steinmetz M, Hood L (1983) Genetic mapping in the MHC complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex. Proc Natl Acad Sci USA 80:3425–3429
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© 1985 Springer-Verlag Berlin Heidelberg
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Rogers, M.J., Galetto, G., Matthai, R., Potter, M. (1985). Qa2 Expression in BALB/c Sublines and a BALB/cLAC Tumor. In: Potter, M. (eds) The BALB/c Mouse. Current Topics in Microbiology and Immunology, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70740-7_6
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DOI: https://doi.org/10.1007/978-3-642-70740-7_6
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