Abstract
Congenital severe combined immunodeficiency diseases (SCID) are relatively heterogeneous conditions with a spontaneously fatal outcome due to infections, usually before 1 year of age. Patients with SCID can be completely cured by bone marrow transplantation (BMT), especially from a genotypically identical donor (Gatti et al. 1968; de Koning et al. 1969; Bortin and Rimm 1977).
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References
Bortin MM, Gale RP, Rimm AA (1981) Allogeneic bone marrow transplantation for 144 patients with severe aplastic anemia. JAMA 245: 1132–1139.
Bortin MM, Rimm AA (1977) Severe combined immunodeficiency disease. Characterization of the disease and results of transplantation. JAMA 238: 591–600.
Bortin MM, Salzstein EC (1969) Graft-versus-host inhibition: Fetal liver and thymus cells to minimize secondary disease. Science 164: 316–319.
Gatti RA, Allen HD, Meuwissen HJ, Hong R, Good RA (1968) Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet 2: 1366–1369.
Koning J de, Van Bekkum DW, Dicke Kα, Dooren LJ, Van Rood JJ, Radl J (1969) Transplantation of bone marrow cells and fetal thymus in an infant with lymphopenic immunological deficiency. Lancet 1: 1223–1227.
Levinsky RJ, Davies EJ, Linch D, Goldstone AH, Beverly PCL (1982) Soybean lectin fractionation of bone marrow to prevent graft-versus-host disease (GvH) in mismatched transplants. Exp Hematol 10[Suppl 10] 96.
Lipinski M, Fridman WH, Tursz T, Vincent C, Pions D, Fellous M (1979) Absence of allogeneic restriction in human T-cell mediated cytotoxicity to Epstein-Barr virus infected target cells. Demonstration of an HLA-linked control at the effector level. J Exp Med 150: 1310.
Meuwissen HJ, Pickering RJ, Pollara B, Porter IH (1975) Combined immunodeficiency disease and adenosine deaminase deficiency. A molecular defect. Academic, New York.
O’Reilly RJ (1982) Transplantation in the treatment of SCID; Methods and efficacy. In: Primary Immunodeficiency Diseases, Birth Defects, The National Foundation, March of Dimes.
Pahwa R, Pahwa S, Good RA, Incefy GS, O’Reilly RJ (1977) Rationale for combined use of fetal liver and thymus for immunological reconstitution in patients with variants of severe combined immunodeficiency. Proc Natl Acad Sci USA 74: 3002–3005.
Prentice HG, Blacklock HA, Janossy G, Bradstock KF, Skeggs D, Goldstein G, Hoffbrand AV (1982) Use of anti-T-cell monoclonal antibody OKT 3 to prevent acute graft-versus-host disease in allogeneic bone marrow transplantation for acute leukemia. Lancet 1: 700–703.
Reisner Y, Kapoor N, Pollack MS, Dupont B, Chagant RSK, Good RA, O’Reilly RJ (1981) Transplantation for acute leukemia with HLA-A and-B non-identical parental bone marrow-cells fractionated with soybean agglutinin and shepp red-blood cells. Lancet 2: 327–331.
Roncarolo MG, Touraine JL, Banchereau J (1984) In vivo and in vitro antietanus toxoid antibody production in patients with HLA-mismatched T-cells following fetal liver and thymus transplantation. In: Griscelli C, Vossen J (eds) Progress in immunodeficiency research and therapy, vol I. Elsevier, Amsterdam, p 179.
Touraine JL (1980) Co-operation between thymus and transplanted precursor cells during reconstitution of immunodeficiencies with bone marrow or fetal liver cells. In: Thierfelder S, Rodt H, Kolb HJ (eds) Immunobiology of bone marrow transplantation. Springer, Berlin Heidelberg, New York, p 141.
Touraine JL (1981) The bare lymphocyte syndrome: report on the Registry. Lancet 1: 319–320.
Touraine JL (1983) Bone marrow and fetal liver transplantation in immunodeficiencies and inborn errors of metabolism: lack of significant restriction of T-cell function in long-term chimeras despite HLA-mismatch. Immunol Rev 71: 103–121.
Touraine JL, Betuel H (1981) Immunodeficiency diseases and expression of HLA antigens. Hum Immunol 2: 147–153.
Touraine JL, Philippe N, Betuel H, Souillet G, Betend B, Souteyrand P, Schmitt D (1981) GvHR and infectious complications in SCID patients treated by bone marrow or fetal liver and thymus transplantation. In: Touraine JL, Gluckman E, Griscelli C (eds) Bone marrow transplantation in Europe: II. Excerpta Medica, Amsterdam, p 209.
Zinkernagel RM (1978) The thymus: Its influence on recognition of “self-major-histocompatibility antigens” by T-cells and consequences for reconstitution of immunodeficiency. Springer Semin Immunopathol 1: 405.
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Touraine, JL. (1987). Treatment of Infants with Severe Combined Immunodeficiency by Bone Marrow or Fetal Liver Transplantation. In: Burgio, G.R., Hanson, L.Å., Ugazio, A.G. (eds) Immunology of the Neonate. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71094-0_18
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DOI: https://doi.org/10.1007/978-3-642-71094-0_18
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