Abstract
Human neonates have an increased incidence of infections when compared with older children and adults (Hill 1985; Santos and Hill 1982; Klein and Marcy 1983). The infections suffered by term and especially premature infants are usually due to bacterial and fungal agents that may not be particularly virulent in older individuals unless they are immunocompromised. These include pathogens such as group B streptococci, Staphylococcus epidermidis, Listeria monocytogenes, Escherichia coli and Candida albicans (Santos and Hill 1982; Klein and Marcy 1983). Furthermore, newborns often develop infections in peripheral sites, such as on the skin, in subcutaneous tissues, or in the lungs. Phagocytic cells, including polymorphonuclear leukocytes and macrophages, are critical to the defense of these areas. Miles et al. (1957) have shown, in experimental animals, that phagocytic cells must arrive at a site of microbial invasion, ingest the pathogen, and kill it within a critical 2-4 h period. If this does not occur, the animal will eventually develop a larger local or systemic infection.
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Hill, H.R., Sacchi, F. (1987). Mechanisms of Abnormal Neutrophil Function in the Human Neonate: Prospects for Therapy. In: Burgio, G.R., Hanson, L.Ã…., Ugazio, A.G. (eds) Immunology of the Neonate. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71094-0_7
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DOI: https://doi.org/10.1007/978-3-642-71094-0_7
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