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Cerebrospinal Fluid and Serum Levels of the Arachidonic Acid Metabolites 6–keto–PGFlα and Thromboxane B2 in Patients with Subarachnoid Hemorrhage

  • Conference paper
Spinal Cord Tumors Experimental Neurosurgery Neurosurgical Intensive Care

Part of the book series: Advances in Neurosurgery ((NEURO,volume 14))

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Abstract

The development of cerebral angiospasm following rupture of an intracranial aneurysm is considered to be one of the major causes of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) (20, 22, 29). Despite many clinical and experimental studies there is still no generally accepted treatment or prophylaxis of cerebral vasospasm. The complicated pathophysiological events which occur during the pre–and postoperative course of SAH and which may lead to fatal arterial narrowing are only partially understood. Recent investigations have elucidated the important role of metabolites of arachidonic acid, especially prostacyclin (PGI2) and thromboxane A2 (TXA2), in the genesis of cerebral vasospasm after aneurysm rupture (1–6, 13, 18, 26) (Fig. 1). The delicate balance between PGI2, a. potent vasodilator and inhibitor of platelet aggregation, and TXA2, a substance with strong vasocon–stricting and platelet aggregating properties, is thought to be essential for the preservation of the tonus of the cerebral vasculature under physiological circumstances. During the course of SAH several pathological events lead to a decreased synthesis of PGI2. Thus the relationship between PGI2 and TXA2 is changed to a disproportionate concentration of TXA2 with consequent platelet aggregation and cerebral vasospasm.

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Authors and Affiliations

  1. Neurochirurgische Klinik und Abteilung für Molekularpharmakologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Germany

    V. Seifert, V. Kaever, D. Stolke, K. Resch & H. Dietz

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  1. V. Seifert
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  2. V. Kaever
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  3. D. Stolke
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  4. K. Resch
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  5. H. Dietz
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Editors and Affiliations

  1. Neurochirurgische Abteilung im Krankenhaus Neukölln, Rudower Str. 56, D-1000, Berlin 47, Germany

    Horst Wenker  & Friedrich Reuter  & 

  2. Neurochirurgische Klinik der Universität Erlangen-Nürnberg, Schwabachanlage 6 (Kopfklinikum), D-8520, Erlangen, Germany

    Margareta Klinger

  3. Neurochirurgische Klinik und Poliklinik, Universitätsklinikum Steglitz, Freie Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45, Germany

    Mario Brock

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© 1986 Springer-Verlag Berlin Heidelberg

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Seifert, V., Kaever, V., Stolke, D., Resch, K., Dietz, H. (1986). Cerebrospinal Fluid and Serum Levels of the Arachidonic Acid Metabolites 6–keto–PGFlα and Thromboxane B2 in Patients with Subarachnoid Hemorrhage. In: Wenker, H., Klinger, M., Brock, M., Reuter, F. (eds) Spinal Cord Tumors Experimental Neurosurgery Neurosurgical Intensive Care. Advances in Neurosurgery, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71108-4_40

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  • DOI: https://doi.org/10.1007/978-3-642-71108-4_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16360-2

  • Online ISBN: 978-3-642-71108-4

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