Abstract
Motor neuron disease, or amyotrophic lateral sclerosis (ALS) is by no means uncommon. The number of new cases per year is more than half that reported for multiple sclerosis although the prevalence is low because of the rapid and fatal course of the disease. It is — and has been for the last 100 years — a major challenge to the neurologist to search for the cause and for an effective treatment of this disease. Despite the prominent symptoms such as progressive generalized paresis in striated muscle, the neuronal damage responsible for paresis is far from generalized, as it is concentrated in lower motor neurons in the spinal cord and brain stem and in neurons in descending tracts of the spinal cord, especially in the pyramidal tract.
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References
Averback P, Crocker P (1982) Regular involvement of Clarke’s nucleus in sporadic amyotrophic lateral sclerosis. Arch Neurol 39: 155–156
Bak IJ, Choi Wb (1974) Electron microscopic investigation of the trochlear nucleus in the cat. Cell Tissue Res 150: 409–423
Bodian D, Howe HA (1941) The rate of progression of poliomyelitis virus in nerves. Bull Johns Hopkins Hosp 69: 79–85
Broadwell RD, Brightman MW (1976) Entry of peroxidase into neurons of the central and peripheral neurons system from extracerebral and cerebral blood. J Comp Neurol 166: 257284
Conradi S, Ronnevi L-O (1982) Cytotoxic factor in plasma from ALS patients provokes haemolysis of normal erythrocytes. Acta Neurol Scand [Suppl 90] 65: 246–247
Conradi S, Ronnevi L-O (1985) Cytotoxic activity in the plasma of ALS patients against normal erythrocytes. Quantitative determinations. J Neurol Sci 68: 135–145
Cullheim S, Kellerth J-O, Conradi S (1977) Evidence for direct synaptic interconnections between cat spinal alpha motoneurons via the recurrent axon collaterals. A morphological study using intracellular injection of horseradish peroxidase. Brain Res 132: 1–10
Digby J, Harrison R, Jehanli A, Lunt GG, Capildeo R, Clifford-Rose F (1984) Immunological changes in motor neurone disease. In: Clifford-Rose F (ed) Research progress in motor neuron disease. Pitman, London, pp 368–378
Hirano A (1982) Aspects of the ultrastructure of amyotrophic lateral sclerosis. In: Rowland LP (ed) Human motor neuron diseases. Raven, New York, pp 75–86
Dyck PJ, Stevens JC, Mulder DW, Espinosa RE (1975) Frequency of nerve fiber degeneration of peripheral motor and sensory neurons in amyotrophic lateral sclerosis. Neurology 25: 781–785
Ikuta F, Makifuchi T, Ichikawa T (1979) Comparative studies of tract degeneration in ALS and other disorders. In: Tsubako T, Toyokura T (eds) Amyotrophic lateral sclerosis. University Park Press, Baltimore, pp 177–200
Kellerth J-O, Conradi S, Berthold C-H (1983) Electron microscopic studies of serially sectioned cat spinal alpha motoneurons: motoneurons innervating fast-twitch (type FF) units of the gastrocnemius muscle. J Comp Neurol 214: 451–458
Kristensson K (1970) Transport of fluorescent protein tracer in peripheral nerves. Acta Neuropathol 16: 293–300
Kuypers HGJM (1981) Anatomy of the descending pathways. In: Brooks VB (ed) The nervous system. Handbook of physiology, sect 1, vol II. American Physiological Society, Washington, pp 597–666
Lagerbäck PA (1985) On ultrastructural studies of cat lumbosacral gamma motor neurons after retrograde labelling with horseradish peroxidase. J Comp Neurol 240: 256–264
Manni E, Bortolami R (1982) Proprioception in eye muscles. In: Lennerstrand G, Zee DS, Keller EL (eds) Functional basis of ocular mobility disorders. Pergamon, Oxford New York, pp 53–64
McLaughlin B (1972) Propriospinal and supraspinal projections to the motor nuclei in the cat spinal cord. J Comp Neurol 144: 475–500
Pullen AH, Sears TA (1978) Modification of “C”-synapses following partial central deafferentation of thoracic motorneurons. Brain Res 145: 141–146
Roisen FJ, Bartfeld H, Donnenfeld H, Baxter J (1982) Neuron-specific in vitro cytotoxicity of sera from patients with amyotrophic lateral sclerosis. Muscle Nerve 5: 48–53
Ronnevi L-O, Conradi S, Karlsson E (1984) Cytotoxic effects of immunoglobulins in amyotrophic lateral sclerosis (ALS). Acta Neurol Scand [Suppl 98] 69: 182–183
Schröder HD (1980) Organization of the motoneurons innervating the pelvis muscles of the male rat. J Comp Neurol 192: 567–587
Schröder HD (1985) Anatomical and pathoanatomical studies on the spinal efferent systems innervating pelvic structures. J Anton Nery Syst 14: 23–48
Sobue K, Matsouka Y, Mukai E, Takayanagi T, Sobue I, Hashizume Y (1981) Spinal and cranial motor nerve roots in amyotrophic lateral sclerosis and X-linked recessive bulbospinal muscular atrophy. Morphometric and teased-fiber study. Acta Neuropathol 55: 227–235
Wolfgram F, Myers L (1972) Toxicity of serum from patients with ALS for anterior horn cells in vitro. Transam Neurol Assoc 97: 19–23
Wunner WH (1982) Is the acetylcholine receptor a rabies virus receptor? Trends in Neurosciences 5: 413–415
Zieglgänsberger W, Reiter C (1974) Interneuronal movement of Procion Yellow in cat spinal neurons. Exp Brain Res 20: 527–530
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© 1987 Springer-Verlag Berlin Heidelberg
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Conradi, S. (1987). Functional Implications of Structure and Synaptology of Motor Neurons in Motor Neuron Disease. In: Struppler, A., Weindl, A. (eds) Clinical Aspects of Sensory Motor Integration. Advances in Applied Neurological Sciences, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71540-2_10
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DOI: https://doi.org/10.1007/978-3-642-71540-2_10
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