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Pharmacokinetic Factors and Their Implication in the Induction of Mouse Liver Tumors by Halogenated Hydrocarbons

  • Conference paper
Mouse Liver Tumors

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 10))

Abstract

The presently available data on pharmacokinetics of halogenated solvents which produce hepatic tumors in B6C3F1 mice, but not in rats, are reviewed. Such compounds are trichloroethylene, perchloroethylene, 1,1,2- trichloroethane, 1,1,2,2-tetrachloroethane, and dichloromethane. It seems likely that higher metabolic rates in mice (compared with other species) may lead to a species-selective toxicity of such compounds. Recurrent cytotoxicity which leads to stimulation of cell replication seems to be a contributing factor in the pathogenesis of mouse liver tumors. However, it is likely that more than one factor contributes to the unique tumor response of the B6C3F1 mouse.

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Author information

Authors and Affiliations

  1. Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystr. 67, D-4600, Dortmund 1, Germany

    H. M. Bolt

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  1. H. M. Bolt
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Toxikologie und Pharmakologie, der Universität Würzburg, Versbacher Landstraße 9, 8700, Würzburg, Germany

    Dietrich Henschler

  3. Institut für Toxikologie, der Universität Mainz, Obere Zahlbacher Straße 67, 6500, Mainz, Germany

    Franz Oesch

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© 1987 Springer-Verlag

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Bolt, H.M. (1987). Pharmacokinetic Factors and Their Implication in the Induction of Mouse Liver Tumors by Halogenated Hydrocarbons. In: Chambers, P.L., Henschler, D., Oesch, F. (eds) Mouse Liver Tumors. Archives of Toxicology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71617-1_18

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  • DOI: https://doi.org/10.1007/978-3-642-71617-1_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17124-9

  • Online ISBN: 978-3-642-71617-1

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