Abstract
Patients with non-Hodgkin’s lymphoma who relapse almost invariably die as a consequence of the disease regardless of histological subtype [1–4]. Ablative therapy supported by autologous bone marrow transplantation (BMT) may result in durable remissions in a proportion of such patients [5–8] although this approach is limited by the high frequency of bone marrow (BM) infiltration. Nadler et al. [9] have used the B-cell-specific monoclonal antibody anti-Bl [10] and rabbit complement to deplete autologous marrow of residual, morphologically undetectable lymphoma. A study is in progress at St. Bartholomew’s Hospital to evaluate the use of ablative therapy supported by such in vitro-treated autologous BM as consolidation of second or subsequent remission in patients with B-cell malignancy.
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© 1987 Springer-Verlag Berlin Heidelberg
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Rohatiner, A.Z.S. et al. (1987). Ablative Therapy Supported by Autologous Bone Marrow Transplantation with In Vitro Treatment of Marrow in Patients with B-Cell Malignancy. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_13
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DOI: https://doi.org/10.1007/978-3-642-72624-8_13
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