Skip to main content
SpringerLink
Log in

Adjuvant Systemic Therapy

  • Chapter
Surgical Oncology

Abstract

There is unchallenged evidence that cancer chemotherapy has made progress in many tumors since the mid-1970s. In particular, certain neoplasms can now be cured only after the administration of adequate polydrug regimens. New strategies have been proposed and applied during the past 10 years to improve the clinical results in various tumors. These consist mainly in adjuvant chemotherapy for patients at high risk of recurrence following standard locoregional treatment, and in the delivery of non-cross-resistant regimens to overcome the problem of primary cell resistance.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bajetta E, Valagussa P, Bonadonna G et al. (1988) Combined modality treatment for stage I—II non-Hodgkin’s lymphomas: CVP versus BACOP chemotherapy. Int J Radiat Oncol Biol Phys 15: 3–12

    Article  PubMed  CAS  Google Scholar 

  • Bloom HJG, Thornoton Jones H (1983) Adjuvant chemotherapy for medulloblastoma: the multicenter controlled trial of the International Society of Pediatric Oncology. Proceedings XIII International Congress of Chemotherapy, Vienna, August 28-September 2

    Google Scholar 

  • Boice JD Jr, Greene MH, Killen JY Jr et al. (1983) Leukemia and preleukemia after adjuvant treatment of gastrointestinal cancer with semustine (methyl-CCNU). N Engl J Med 309:1079–1084

    Article  PubMed  Google Scholar 

  • Bonadonna G (guest ed) (1986) Breast cancer. Semin Oncol 13: 383–449

    Google Scholar 

  • Bonadonna G, Valagussa P (1989) Influence of clinical trials on current treatment strategy for malignant lymphomas. J Clin Oncol (in press)

    Google Scholar 

  • Bonadonna G, Valagussa P (1985) Adjuvant systemic therapy for resectable breast cancer. J Clin Oncol 3: 259–275

    PubMed  CAS  Google Scholar 

  • Bonadonna G, Valagussa P (1987) Current status of adjuvant chemotherapy for breast cancer. Semin Oncol 14: 8–22

    PubMed  CAS  Google Scholar 

  • Bonadonna G, Valagussa P (1988) The contribution of medicine to the primary treatment of breast cancer. Cancer Res 48: 2314–2324

    PubMed  CAS  Google Scholar 

  • Bonadonna G, Valagussa P (1989) Role of chemotherapy in stage I breast cancer. In: De Vita VT, Hellman S, Rosenberg SA (eds) Important advances in oncology 1989. Lip-pincot, Philadelphia

    Google Scholar 

  • Bonadonna G, Valagussa P, Rossi A et al. (1985) Ten-year experience with CMF-based adjuvant chemotherapy in resectable breast cancer. Breast Cancer Res Treat 5: 95–115

    Article  PubMed  CAS  Google Scholar 

  • Breast Cancer Trials Committee (1987) Adjuvant tamoxifen in the management of operable breast cancer: the Scottish trial. Lancet 2: 171–175

    Google Scholar 

  • Chapman RM, Sutcliffe SB, Malpas JS (1981) Male gonadal dysfunction in Hodgkin’s disease. JAMA 245:1323–1328

    Article  PubMed  CAS  Google Scholar 

  • D’Angio GJ (1985) Clinical trials in Wilms’ tumor. In: Veronesi U, Bonadonna G (eds) Clinical trials in cancer medicine: past achievements and future prospects. Bristol Myers Symposia, vol 6. Academic, Orlando, pp 539–546

    Google Scholar 

  • Donaldson SS (1985) The value of adjuvant chemotherapy in the management of sarcomas in children. Cancer 55: 2184–2197

    Article  PubMed  CAS  Google Scholar 

  • Douglass HO Jr, Stablein DM (1983) Controlled trial of adjuvant chemotherapy following curative resection for gastric cancer. Cancer 49: 1116–1122

    Google Scholar 

  • Edmonson JH, Green SJ, Ivins JC et al. (1984) A controlled pilot study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma. J Clin Oncol 2: 152–156

    PubMed  CAS  Google Scholar 

  • Engstrom PF, Lavin PT, Douglass HO et al. (1985) Postoperative adjuvant 5-fluorouracil plus methyl-CCNU therapy for gastric cancer. Cancer 55: 1868–1873

    Article  PubMed  CAS  Google Scholar 

  • Evans AE (1983) Therapeutic approaches to medulloblastoma and results. The trial of the Children Cancer Study Group (CCSG) and Radiation Therapy Oncology Group (RTOG). Proceedings XIII International Congress of Chemotherapy, Vienna, August 28-September 2

    Google Scholar 

  • Fisher B, Rockette H, Fisher ER et al. (1985) Leukemia in breast cancer patients following adjuvant chemotherapy or postoperative radiotherapy: the NSABP experience. J Clin Oncol 3: 1640–1658

    PubMed  CAS  Google Scholar 

  • Fisher B, Wolmark N, Rockette H et al. (1988) Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: result from NSABP Protocol R-01. J Natl Cancer Inst 80: 21–29

    Article  PubMed  CAS  Google Scholar 

  • Frei E III (1985) Curative cancer chemotherapy. Cancer Res 45: 6523–6537

    PubMed  Google Scholar 

  • Gastrointestinal Tumor Study Group (GITSG) (1984) Adjuvant therapy of colon cancer: results of a prospective randomized trial. N Engl J Med 310: 737–743

    Article  Google Scholar 

  • Goldie JH, Coldman AJ (1985) Genetic instability in the development of drug resistance. Semin Oncol 12: 222–230

    PubMed  CAS  Google Scholar 

  • Goorin AM, Abelson HT, Frei E III (1985) Osteosarcoma: fifteen years later. N Engl J Med 313: 1637–1643

    Article  PubMed  CAS  Google Scholar 

  • Higgins GA, Amadeo JH, Smith DE et al. (1985) Efficacy of prolonged intermittent therapy with combined 5-FU and methyl-CCNU following resection for gastric carcinoma. Cancer 52: 1105–1112

    Article  Google Scholar 

  • Holmes EC, Eagan RT and the Lung Cancer Study Group (1984) Surgical adjuvant therapy for resectable stage II/III adenocarcinoma and large cell undifferentiated carcinoma of the lung. Proc Am Soc Clin Oncol 3: 220

    Google Scholar 

  • Kelsen D (guested) (1984) Esophageal cancer. Semin Oncol 11: 1–201

    Google Scholar 

  • Martin DS, Fugman RA, Stolfi RL et al. (1975) Solid tumor animal model therapeutically predictive for human breast cancer. Cancer Chemother Rep 5: 89–109

    Google Scholar 

  • Maurer H, Foulkes M, Gehan E (1983) Intergroup Rhabdomyosarcoma Study (IRS) II: preliminary report. Proc Am Soc Clin Oncol 2: 70

    Google Scholar 

  • Meadows AT, Baum E, Fossati-Bellani F et al. (1985) Second malignant neoplasms in children: an update from the Late Effects Study Group. J Clin Oncol 3: 532–538

    PubMed  CAS  Google Scholar 

  • Monfardini S, Banfi A, Bonadonna G et al. (1980) Improved 5-year survival after combined radiotherapy-chemotherapy for stage I—II non-Hodgkin’s lymphomas. Int J Radiat Oncol Biol Phys 6: 125–134

    Article  PubMed  CAS  Google Scholar 

  • Morris Jones PH, Pearson D, Johnson AJ (1978) Medical Research Council: managment of nephroblastoma in childhood. Arch Dis Child 53: 112–119

    Article  Google Scholar 

  • National Institutes of Health (1985) Proceedings of the Consensus Development Conference in limb-sparing treatment of adult soft tissue sarcomas and osteosarcomas. Cancer Treat Symp 3: 1–159

    Google Scholar 

  • Noladex Adjuvant Trial Organization (1985) Controlled trial of tamoxifen as single adjuvant agent in management of early breast cancer. Analysis at six years. Lancet 1: 836–840

    Google Scholar 

  • Norton L (1985) Implication of kinetic heterogeneity in clinical oncology. Semin Oncol 12: 231–249

    PubMed  CAS  Google Scholar 

  • Perez CA, Tafft M, Nesbit E et al. (1981) The role of radiation therapy in the management of nonmetastatic Ewing sarcoma of bone: report of the Intergroup Ewing’ s Sarcoma Study. Int J Radiat Oncol Biol Phys 7: 141–149

    Article  PubMed  CAS  Google Scholar 

  • Ragaz J, Band PR, Goldie JH (eds) (1986) Preoperative (neoadjuvant) chemotherapy. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Rosen G, Marcove RC, Huvos AG et al. (1983) Primary osteogenic sarcoma: eight-year experience with adjuvant chemotherapy. J Cancer Res Clin Oncol [Suppl] 106: 55–67

    Article  PubMed  Google Scholar 

  • Rosenberg SA, Kaplan HS (1985) The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin’s disease: 1962–1984. nt J Radiat Oncol Biol Phys 11: 5–22

    Article  CAS  Google Scholar 

  • Rossi A, Molinari R, Marubini E et al. (1986) Adjuvant chemotherapy after complete response of radiotherapy in nasopharyngeal cancer: follow-up of a randomized study. Proc Am Soc Clin Oncol 5: 147

    Google Scholar 

  • Santoro A, Bonadonna G, Valagussa P et al. (1987) Long-term results of combined chemotherapy-radiotherapy approach in Hodgkin’s disease. Superiority of ABVD plus radiotherapy versus MOPP plus radiotherapy. J Clin Oncol 5: 27–37

    PubMed  CAS  Google Scholar 

  • Schein PS, Sherlock P (guest eds) (1985) Gastric cancer. Semin Oncol 12: 1–53

    Google Scholar 

  • Schilsky RL (guest ed) (1985) Tumor cell heterogeneity. Semin Oncol 12: 201–353

    Google Scholar 

  • Schilsky RL, Sherins RJ, Hubbard SM et al. (1981) Long-term follow-up of ovarian function in women treated with MOPP chemotherapy for Hodgkin’s disease. Am J Med 71: 552–556

    Article  PubMed  CAS  Google Scholar 

  • Shapiro WL (guest ed) (1986) Brain tumors. Semin Oncol 13: 1–122

    Google Scholar 

  • Skipper HE, Schabel FM JR (1984) Tumor stem cell heterogeneity: implication with respect to classification of cancers by chemotherapeutic effect. Cancer Treat Rep 68: 43–61

    PubMed  CAS  Google Scholar 

  • Taylor SG IV, Applebaum E, Showell JL et al. (1985) A randomized trial of adjuvant chemotherapy in head and neck cancer. J Clin Oncol 3: 672–679

    PubMed  Google Scholar 

  • Valagussa P, Santoro A, Fossati-Bellani F et al. (1986) Second acute leukemia and other malignancies following treatment for Hodgkin’s disease. J Clin Oncol 4: 830–837

    PubMed  CAS  Google Scholar 

  • Valagussa P, Tancini G, Bonadonna G (1987) Second malignancies after CMF for resectable breast cancer. J Clin Oncol 5: 1138–1142

    PubMed  CAS  Google Scholar 

  • Valagussa P, Santoro A, Fossati-Bellani F et al. (1988) Hodgkin’s disease and second malignancies. Proc Am Soc Clin Oncol 7: 227

    Google Scholar 

  • Veronesi U, Adamus J, Aubert C et al. (1982) A randomized trial of adjuvant chemotherapy and immunotherapy in cutaneous melanoma. N Engl J Med 307: 913–916

    Article  PubMed  CAS  Google Scholar 

  • Wagener DJT, Blijham GH, Smeets JBE et al. (eds) (1985) Primary chemotherapy in cancer medicine. Liss, New York

    Google Scholar 

  • Weiss RB, Stablein DM, Muggia FM et al. (1986) Toxicity of chemotherapy as adjuvant or salvage treatment in early stage nonseminomatous testicular cancer. Proc Am Soc Clin Oncol 5: 99

    Google Scholar 

  • Wolmark N, Fisher B, Rockette H et al. (1988) Postoperative adjuvant chemotherapy or BCG for colon cancer: results from NSABP Protocol C-01. J Natl Cancer Inst 80: 30–36

    Article  PubMed  CAS  Google Scholar 

  • Young RC (guest ed) (1984) Ovarian carcinoma. Semin Oncol 11: 202–332

    Google Scholar 

Download references

Authors
  1. G. Bonadonna
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Fossati-Bellani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Valagussa
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian, 1, 20133, Milano, Italy

    Umberto Veronesi (Direttore Generale) (Direttore Generale)

  2. Department of Surgery, Haukeland University Hospital, University of Bergen, 5021, Bergen, Norway

    Bo Arnesjø

  3. Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UK

    Ian Burn

  4. Department of Urology, A.Z. Middelheim, Vrue Universiteit Brussel, Lindendreef 1, 2020, Antwerpen, Belgium

    Louis Denis

  5. Cattedra di Chirurgia Generale, II facolta’, Università di Napoli, Via Pansini, 5, 80131, Napoli, Italy

    Francesco Mazzeo

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bonadonna, G., Fossati-Bellani, F., Valagussa, P. (1989). Adjuvant Systemic Therapy. In: Veronesi, U., Arnesjø, B., Burn, I., Denis, L., Mazzeo, F. (eds) Surgical Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72646-0_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72646-0_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72648-4

  • Online ISBN: 978-3-642-72646-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation