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Molecular Mechanisms of Pathogenicity in Shigella flexneri

  • Conference paper
Molecular Basis of Viral and Microbial Pathogenesis

Abstract

Although shigellosis is endemic throughout the world, it is of special concern in developing areas in which poor sanitation and low personal hygiene standards are responsible for a large number of cases. Children represent the major target of the disease, and malnutrition certainly accounts for the severity of the cases as well as a significant rate of mortality.

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References

  1. La Brec EH, Schneider H, Magnani TJ, Formal SB (1964) Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery. J Bacteriol 88: 1503–1518

    Google Scholar 

  2. Formal SB, Hale TL, Sansonetti PJ (1983) Invasive enteric pathogens. Rev Infect Dis 5:5702–5707

    Article  Google Scholar 

  3. Sereny B (1957) Experimental keratoconjunctivitis shigellosa. Acta Microbiol Acad Sci Hung 4:367–376

    PubMed  CAS  Google Scholar 

  4. Formal SB, Kundel D, Schneider H, Kunev N, Sprinz H (1961) Studies with Vibrio c holerae in the ligated loop of the rabbit intestine. Br J Exp Pathol 42:504–510

    PubMed  CAS  Google Scholar 

  5. Sansonetti PJ, Kopecko DJ, Formal SB (1982) Involvement of a plasmid in the invasive ability of Shigella flexneri. Infect immun 35:852–860

    PubMed  CAS  Google Scholar 

  6. Sansonetti PJ, Kopecko DJ, Formal SB (1981) Shigella sonnei plasmids: evidence that a large plasmid is necessary for virulence. Infect Immun 34:75–83

    PubMed  CAS  Google Scholar 

  7. Sansonetti PJ, d’Hauteville H, Ecöbichon C, Pourcel C (1983) Molecular expression of virulence plasmids in Shigella and entero-invasive Esoheriohia coli. Ann Microbiol (Paris) 134 A:295–318

    Google Scholar 

  8. Sansonetti PJ, d’Hauteville H, Formal SB, Toucas M (1982) Plasmid mediated in- vasiveness of “Shigella-like” Esoheriohia coli. Ann Microbiol (Paris) 133:351–355

    CAS  Google Scholar 

  9. Sansonetti PJ, Hale TL, Dammin GI, Kapper C, Collins HH, Formal SB (1983) Alterations in the pathogenicity of Esoheriohia coli K12 after transfer of plasmid and chromosomal genes from Shigella flexneri. Infect Immun 39:1392–1402

    PubMed  CAS  Google Scholar 

  10. Formal SB, Gemski P Jr, Baron LS, La Brec EH (1970) Genetic transfer of Shigella flexneri antigens to Esoheriohia coli K12. Infect Immun 1:279–287

    PubMed  CAS  Google Scholar 

  11. Formal SB, Gemski P Jr, Baron LS, La Brec EH (1971) A chromosomal locus which controls the ability of Shigella flexneri to evoke keratoconjunctivitis. Infect Immun 3:73–79

    PubMed  CAS  Google Scholar 

  12. Formal SB, La Brec EH, Kent TH, Falkow S (1965) Abortive intestinal infection with an Esoheriohia coli-Shigella flexneri hybrid strain. J Bacteriol 89:1374– 1382

    PubMed  CAS  Google Scholar 

  13. Maurelli AT, Baudry B, d’Hauteville H, Hale TL, Sansonetti PJ (1985) Cloning of plasmid DNA sequences involved in invasion of HeLa cells by Shigella flexneri ,Infect Immun 49:164–171

    PubMed  CAS  Google Scholar 

  14. Hale TL, Oaks EV, Formal SB (1985) Identification and antigenic characterization of virulence-associated, plasmid-coded proteins of Shigella spp. and enteroin- vasive Esoheriohia coli. Infect Immun 50:620–629

    CAS  Google Scholar 

  15. Sansonetti PJ, Ryter A, Clerc P, Maurelli AT, Mounier J (1986) Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid- mediated contact hemolysis. Infect Immun 51:461–469

    PubMed  CAS  Google Scholar 

  16. Clerc PL, Ryter A, Mounier J, Sansonetti PJ (1987) Plasmid-mediated early killing of eukaryotic cells by Shigella flexneri as studied by infection of J774 macrophages. Infect Immun 55:521–527

    PubMed  CAS  Google Scholar 

  17. Okamura N, Nakaya R (1977) Rough mutant of Shigella flexneri 2a that penetrates culture cells but does not evoke keratoconjunctivitis in guinea-pigs. Infect Immun 17:4–8

    PubMed  CAS  Google Scholar 

  18. Kopecko DJ, Washington O, Formal SB (1980) Genetic and physical evidence of plasmid control of Shigella sonnei form I cell surface antigen. Infect Immun 29:207–214

    PubMed  CAS  Google Scholar 

  19. Watanabe H, Timmis KN (1984) A small plasmid in Shigella dysenteriae 1 specifies one or more functions essential for O-antigen production and bacterial virulence. Infect Immun 43:391–396

    PubMed  CAS  Google Scholar 

  20. Payne SM, Niesel DW, Peixotto SS, Lawlor KM (1983) Expression of hydroxamate and phenolate siderophores by Shigella flexneri. J Bacteriol 155:949–955

    PubMed  CAS  Google Scholar 

  21. Griffiths E, Stevenson P, Hale TL, Formal SB (1985) Synthesis of aerobactin and a 76,000 dalton iron-regulated outer membrane protein by Escherichia coli ,K12- Shigella flexneri hybrids. Infect Immun 49:67–71

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Service des Entérobactéries, Unité INSERM 199, Institut Pasteur, 28 rue du Docteur Roux, 75724, Paris Cedex 15, France

    P. J. Sansonetti, B. Baudry, P. Clerc, A. T. Maurelli & X. Nassif

  2. Unité de Microscopie Electronique, Institut Pasteur, 28 rue du Docteur Roux, 75724, Paris Cedex 15, France

    A. Ryter

Authors
  1. P. J. Sansonetti
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  2. B. Baudry
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  3. P. Clerc
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  4. A. T. Maurelli
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  5. X. Nassif
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  6. A. Ryter
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Editor information

Editors and Affiliations

  1. Institut für Virologie der Universität, Frankfurter Straße 107, 6300, Gießen, Germany

    Rudolf Rott

  2. Institut für Genetik und Mikrobiologie der Universität, Röntgenring 11, 8700, Würzburg, Germany

    Werner Goebel

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© 1987 Springer-Verlag Berlin Heidelberg

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Sansonetti, P.J., Baudry, B., Clerc, P., Maurelli, A.T., Nassif, X., Ryter, A. (1987). Molecular Mechanisms of Pathogenicity in Shigella flexneri . In: Rott, R., Goebel, W. (eds) Molecular Basis of Viral and Microbial Pathogenesis. Colloquium der Gesellschaft für Biologische Chemie 9.–11. April 1987 in Mosbach/Baden, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73214-0_12

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  • DOI: https://doi.org/10.1007/978-3-642-73214-0_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73216-4

  • Online ISBN: 978-3-642-73214-0

  • eBook Packages: Springer Book Archive

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