Abstract
The use of monoclonal antibodies (MAB) for diagnostic and therapeutic purposes depends on their accumulation and retention in solid tumor tissue [1, 2, 4, 5, 8, 13, 14]. The accuracy of presently available methods is subject to inherent limitations with respect to scintigraphic localization. Furthermore, the therapeutic application appears only rarely succussful [3,11,12]. This situation demands a systemic investigation of factors determining the biodistribution of MAB in both tumor and normal tissue.
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© 1989 Springer-Verlag Berlin · Heidelberg
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Kraas, E. et al. (1989). Specificity, Kinetics, and Distribution of Monoclonal Antibodies to Carcinoembryonic Antigen in Human Colorectal Carcinoma by Ex Vivo Human Tumor Perfusion. In: Beger, H.G., Büchler, M., Reisfeld, R.A., Schulz, G. (eds) Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73721-3_25
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DOI: https://doi.org/10.1007/978-3-642-73721-3_25
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