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Use of Positron Emission Tomography to Study Patterns of Brain Metabolism in Relation to Age and Disease: A Correlation Matrix Approach

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Regulatory Mechanisms of Neuron to Vessel Communication in the Brain

Part of the book series: NATO ASI Series ((ASIH,volume 33))

Abstract

Region-by-region comparisons of mean rCMRg1c data have proven uninformative for understanding behavior and cognition in patients with Down syndrome and childhood onset autism, and in the healthy elderly. Such comparisons ignore an important dimension of brain metabolism, namely patterns of regional cerebral metabolic rates. This paper shows that a correlation matrix approach can be used to determine these patterns, and to relate them to underlying functional neuroanatomy in health and disease.

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Authors and Affiliations

  1. Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bldg. 10, Rm. 6C-103, Bethesda, Md., 20892, USA

    Stanley I. Rapoport & Barry Horwitz

Authors
  1. Stanley I. Rapoport
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  2. Barry Horwitz
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Editor information

Editors and Affiliations

  1. Department of Experimental Medicine and Biochemical Sciences II, University of Rome, Via Orazio Raimondo, 00173, Rome, Italy

    Fiorenzo Battaini  & Marco Trabucchi  & 

  2. Department of Pharmacobiology, University of Bari, Via Re David 4, 70100, Bari, Italy

    Stefano Govoni

  3. Institute of Pharmacological Sciences, Faculty of Pharmacology, University of Milano, Via Balzaretti, 9, 20133, Milano, Italy

    Maria Sandra Magnoni

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© 1989 Springer-Verlag Berlin Heidelberg

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Rapoport, S.I., Horwitz, B. (1989). Use of Positron Emission Tomography to Study Patterns of Brain Metabolism in Relation to Age and Disease: A Correlation Matrix Approach. In: Battaini, F., Govoni, S., Magnoni, M.S., Trabucchi, M. (eds) Regulatory Mechanisms of Neuron to Vessel Communication in the Brain. NATO ASI Series, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74152-4_18

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  • DOI: https://doi.org/10.1007/978-3-642-74152-4_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74154-8

  • Online ISBN: 978-3-642-74152-4

  • eBook Packages: Springer Book Archive

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