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Epidermal Mediators for Lymphocytes in Contact Eczema

  • Conference paper
Current Topics in Contact Dermatitis

Summary

A total of 56 persons were studied for the presence of epidermal mediators in tuberculin skin tests, allergic patch tests, or irritant reactions from sodium lauryl sulphate (SLS) 3%. Epidermis was obtained with the suction blister technique, homogenized, dialysed, and ultrafiltered, leaving substances larger than 3 kDa for further studies. The epidermal homogenate was assayed for interleukin-1 (IL-1) activity and for the presence of epidermal lymphocyte chemotactic factor (ELCF). Our results show that simple occlusion of the skin in non-eczematous persons does not induce any significant amount of mediators. However, if the person in question suffers from irritant eczema, then occlusion per se will induce a significant amount of ELCF, but not IL-1. Both mediators are induced following a cell-mediated immune reaction in the skin irrespective of the presence of eczema. In patients with cutaneous allergy, the mediators are expressed in normal-looking, non-tested skin, when an allergic patch test is applied elsewhere. This may in part explain the excited skin syndrome.

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References

  1. Larsen CG, Ternowitz T, Larsen FG, Thestrup-Pedersen K (1988) Epidermis and lymphocyte interactions during a tuberculin skin reaction. I. Increased ETAF/IL-1 like activity, expression of tissue antigens and mixed skin lymphocyte reactivity. Arch Dermatol Res 280: 83–89.

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Author information

Authors and Affiliations

  1. Department of Dermatology, University of Aarhus, Marselisborg Hospital, 8000, Aarhus C., Denmark

    C. G. Larsen, T. Ternowitz & K. Thestrup-Pedersen

Authors
  1. C. G. Larsen
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  2. T. Ternowitz
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  3. K. Thestrup-Pedersen
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Editor information

Editors and Affiliations

  1. Hautklinik der Universität Heidelberg, Voßstraße 2, 6900, Heidelberg 1, Germany

    Peter Frosch

  2. Department of Medical Research (Dermatology), Katholieke Universiteit Leuven, 3000, Leuven, Belgium

    A. Dooms-Goossens P.Ph., Ph.D.

  3. Unit and Laboratory of Occupational and Environmental Dermatology, Catholic University of Louvain, 30, Clos Chapelle-aux-Champs, UCL 3033, 1200, Brussels, Belgium

    J.-M. Lachapelle M. D. (Professor of Dermatology) (Professor of Dermatology)

  4. St. John’s Hospital for Diseases of the Skin, Lisle Street, London, WC2H 7BJ, Great Britain

    R. J. G. Rycroft

  5. Department of Pathology, Free University Hospital, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    R. J. Scheper

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© 1989 Springer-Verlag Berlin Heidelberg

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Larsen, C.G., Ternowitz, T., Thestrup-Pedersen, K. (1989). Epidermal Mediators for Lymphocytes in Contact Eczema. In: Frosch, P., Dooms-Goossens, A., Lachapelle, JM., Rycroft, R.J.G., Scheper, R.J. (eds) Current Topics in Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74299-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-74299-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74301-6

  • Online ISBN: 978-3-642-74299-6

  • eBook Packages: Springer Book Archive

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