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Role of Preoperative Therapy in High-Risk Breast Cancer: Review

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High-Risk Breast Cancer

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Abstract

Preoperative chemotherapy combines appealing theoretical concepts of tumor biology and therapy, linking the postsurgical behavior of metastases with a potentially beneficial effect of the systemic chemotherapy given before the definitive surgery. There is evidence from experimental and some clinical studies indicating enhancement of cell kinetics after noncurative cytoreduction [8, 12–14, 2b, 53, 55]. According to some data, these changes are deleterious to the host, and a reduction of the survival was documented compared with animals without cytoreduction [12, 53]. Enhancement of the metastatic potential, and of the systemic spread of the residual clones, is suspected, and according to some data, may be improved by preoperative chemotherapy [5, 12]. Although preoperative chemotherapy has been used for several years routinely in head and neck tumors [16] and osteosarcomas [48], attempts at its implementation as a conceptually new approach have started recently for other tumors [15, 22, 42, 56] as seen from several international conventions on neoadjuvant therapy held over the last few years [22, 24, 42, 56].

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Authors and Affiliations

  1. British Columbia Cancer Agency, Vancouver, B.C., Canada

    J. Ragaz

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  1. J. Ragaz
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  1. Medical Oncology, British Columbia Cancer Agency, 600 West 10th Avenue, V5Z 4E6, Vancouver, B.C., Canada

    Joseph Ragaz MD, FRCP

  2. Foundation for Clinical Research Inc., 80 East End Avenue, 10028, New York, NY, USA

    Irving M. Ariel MD

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© 1991 Springer-Verlag Berlin · Heidelberg

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Ragaz, J. (1991). Role of Preoperative Therapy in High-Risk Breast Cancer: Review. In: Ragaz, J., Ariel, I.M. (eds) High-Risk Breast Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74728-1_4

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  • DOI: https://doi.org/10.1007/978-3-642-74728-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74730-4

  • Online ISBN: 978-3-642-74728-1

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