Abstract
The reports of elevated carboxyhemoglobin (COHb) levels following exposure to dichloromethane (DCM) stimulated the research on the toxicology of this solvent. The metabolic pathway of DCM to carbon monoxide (CO) involves an oxygen insertion catalyzed by cytochrome P-450 (Gargas et al 1986), mainly by the isozyme cytochrome P-450 IIE1 (CYP2E1). Pyrazole (PYR) is known to depress the oxidative metabolism of DCM, but based upon the catalytic, spectral, and immunological properties it appears to induce CYP2E1 (Palakodety et al 1988). The effect of PYR on carboxyhemoglobinemia following DCM administration in rats was investigated.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Gargas ML, Clewell III HJ, Andersen ME (1986) Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways. Toxicol Appl Pharmacol 82:211–223
Kim YC, Carlson GP (1986) The effect of an unusual workshift on chemical toxicity I. Studies on the exposure of rats and mice to dichloromethane. Fund Appl Toxicol 6:162–171
Lieber CS, Rubin E, DeCarli LM, Misra PS, Gang H (1970) Effects of pyrazole on hepatic function and structure. Lab Invest 22:615–621
Palakodety RB, Clejan LA, Krikun G, Feierman DE, Cederbaum AI (1988) Characterization and identification of a pyrazole-inducible form of cytochrome P-450. J Biol Chem 263:878–884
Rydberg U, Buijten J, Neri A (1972) Kinetics of some pyrazole derivates in the rat. J Pharm Pharmacol 24:651–652
Schmidt P (1988) Biologische Kontrollmethoden in der Arbeitsmedizin. Verlag Volk und Gesundheit, Berlin, 345–346
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Pankow, D., Kretschmer, S., Weise, M. (1991). Effect of Pyrazole on Dichloromethane Metabolism to Carbon Monoxide. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_51
Download citation
DOI: https://doi.org/10.1007/978-3-642-74936-0_51
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-51422-0
Online ISBN: 978-3-642-74936-0
eBook Packages: Springer Book Archive