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Progress in Vaccine Development for Prevention of Human Cytomegalovirus Infection

  • Conference paper
Cytomegaloviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 154))

Abstract

The infectious agent most frequently causing congenital malformations is the human cytomegalovirus (HCMV). HCMV infection is found in about 1% of newborns, and about 10%–15% of the infected children suffer either from immediate symptoms or late sequelae of the infection. Clinically apparent infections after birth are characterized by cytomegalic inclusion diseases (CIDs) in about 5% of the infected children. Another 5% have atypical involvement, usually with some damage of the CNS and 90% have no symptoms at birth. Among the most severely affected children mortality may be 30%. About 10%–15% of the children who are infected but asymptomatic at birth eventually develop mental retardation, chorioretinitis, microcephaly, and hearing loss (Weller 1971; Pass et al. 1980; Stagno et al. 1983, 1984).

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Authors and Affiliations

  1. The Wistar Institute, 36th Street at Spruce, Philadelphia, PA, 19104, USA

    E. Gönczöl & S. Plotkin

Authors
  1. E. Gönczöl
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  2. S. Plotkin
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Editors and Affiliations

  1. Fred Hutchinson Cancer Research Center, University of Washington, 1124, Columbia Street, Seattle, WA, 98104, USA

    James K. McDougall PhD. (Research Professor of Pathology, Member) (Research Professor of Pathology, Member)

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© 1990 Springer-Verlag Berlin Heidelberg

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Gönczöl, E., Plotkin, S. (1990). Progress in Vaccine Development for Prevention of Human Cytomegalovirus Infection. In: McDougall, J.K. (eds) Cytomegaloviruses. Current Topics in Microbiology and Immunology, vol 154. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74980-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-74980-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74982-7

  • Online ISBN: 978-3-642-74980-3

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