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Caprine Arthritis Encephalitis Lentivirus Transmission and Disease

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Retrovirus Infections of the Nervous System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 160))

Abstract

Lentiviruses occur in several species of animals and those that share DNA sequence homology with human immunodeficiency virus type 1 (HIV-1) include equine infectious anemia virus (EIAV) of horses, maedi/visna virus of sheep, and caprine arthritis encephalitis virus (CAEV) of goats (Chiu et al. 1985; Sonigo et al. 1985; Pyper et al. 1986). Visna virus and related lentiviruses of sheep are distinguished from goat CAEV isolates by nucleic acid hybridization, DNA sequence, and immunologic reactivity (reviewed in Cheevers and McGuire 1988); however, the viruses can reciprocally infect sheep or goats (Banks et al. 1983).

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References

  • Adams DS, Crawford TB, Banks KL, McGuire TC, Perryman LE (1980a) Immune responses of goats persistently infected with caprine arthritis-encephalitis virus. Infect Immun 28: 421–427

    PubMed  CAS  Google Scholar 

  • Adams DS, Crawford TB, Klevjer-Anderson P (1980b) A pathogenetic study of the early connective tissue lesions of viral caprine arthritis-encephalitis. Am J Pathol 99: 257–278

    PubMed  CAS  Google Scholar 

  • Adams DS, Klevjer-Anderson P, Carlson JL, McGuire TC, Gorham JR (1983) Transmission and control of caprine arthritis-encephalitis virus. Am J Vet Res 44: 1670–1675

    PubMed  CAS  Google Scholar 

  • Adams DS, Oliver RE, Ameghino E, DeMartini, JC, Verwoerd DW, Houwers DJ, Waghela S, Gorham JR, Hyllseth B, Dawson M, Trigo FJ, McGuire TC (1984) Serological evidence of caprine arthritis-encephalitis infection in eleven of fourteen countries tested. Vet Rec 115: 493–495

    Article  PubMed  CAS  Google Scholar 

  • Anderson LW, Klevjer-Anderson P, Liggitt HD (1983a) Susceptibility of blood-derived monocytes and macrophages to caprine arthritis-encephalitis virus. Infect Immun 41: 837–840

    PubMed  CAS  Google Scholar 

  • Anderson LW, Klevjer-Anderson P, McGuire TC (1983b) Immune rabbit sera do not recognize antigenic variants of caprine arthritis-encephalitis virus isolated during persistent infection. Infect Immun 42: 845–847

    PubMed  CAS  Google Scholar 

  • Banks KL, Adams DS, McGuire TC, Carlson JL (1983) Experimental infection of sheep by caprine arthritis-encephalitis virus and goats by progressive pneumonia virus. Am J Vet Res 44: 2307–2311

    PubMed  CAS  Google Scholar 

  • Banks KL, Jacobs CA, Michaels FH, Cheevers WP (1987) Lentivirus infection augments concurrent antigen-induced arthritis. Arthritis Rheum 30: 1046–1053

    Article  PubMed  CAS  Google Scholar 

  • Caporale VP, Balbo S, Lelli R, Semproni G, Caccia A, Baldelli R (1985) Investigations on lentivirus infections in Italian caprine population. Zbl Veterinarmed [B] 32: 652–659

    CAS  Google Scholar 

  • Cheevers WP, McGuire TC (1988) The lentiviruses: maedi/visna, caprine arthritis-encephalitis, and equine infectious anemia. Adv Virus Res 34: 189–215

    Article  PubMed  CAS  Google Scholar 

  • Cheevers WP, Knowles DP, McGuire TC, Cunningham DR, Adams DS, Gorham JR (1988) Chronic disease in goats orally infected with two isolates of the caprine arthritis-encephalitis lentivirus. Lab Invest 58: 510–517

    PubMed  CAS  Google Scholar 

  • Cheevers WP, Roberson S, Klevjer-Anderson P, Crawford TB (1981) Characterization of caprine arthritis-encephalitis virus: a retrovirus of goats. Arch Virol 67: 111–117

    Article  PubMed  CAS  Google Scholar 

  • Chiu IM, Yaniv A, Dahlberg JE, Gazit A, Skuntz SF, Tronick SR, Aaronson SA (1985) Nucleotide sequence evidence for relationship of AIDS retrovirus to lentiviruses. Nature 317: 366–368

    Article  PubMed  CAS  Google Scholar 

  • Cork LC, Davis WC (1975) Ultrastructural features of viral leukoencephalomyelitis of goats. Lab Invest 32: 359–365

    PubMed  CAS  Google Scholar 

  • Cork LC, Narayan O (1980) The pathogenesis of viral leukoencephalomyelitis-arthritis of goats. I. Persistent viral infection with progressive pathologic changes. Lab Invest 42: 596–602

    Google Scholar 

  • Cork LC, Hadlow WJ, Crawford TB, Gorham JR, Piper RC (1974a) Infectious leukoencephalomyelitis of young goats. J Infect Dis 129: 134–141

    Article  PubMed  CAS  Google Scholar 

  • Cork LC, Hadlow WJ, Gorham JR, Piper RC, Crawford TB (1974b) Pathology of viral leukoencephalomyelitis of goats. Acta Neuropathol (Berl) 29: 281–292

    Article  CAS  Google Scholar 

  • Crawford TB, Adams DS (1981) Caprine arthritis-encephalitis: clinical features and presence of antibody in selected goat populations. J Am Vet Med Assoc 178: 713–719

    PubMed  CAS  Google Scholar 

  • Crawford TB, Adams DS, Cheevers WP, Cork LC (1980a) Chronic arthritis in goats caused by a retrovirus. Science 207: 997–999

    Article  PubMed  CAS  Google Scholar 

  • Crawford TB, Adams DS, Sande RD, Gorham JR, Henson JB (1980b) The connective tissue component of the caprine arthritis-encephalitis syndrome. Am J Pathol 100: 443–454

    PubMed  CAS  Google Scholar 

  • Cross RF, Smith CK, Moorhead PD (1975) Vertical transmission of progressive penumonia virus of sheep. Am J Vet Res 36: 465–468

    PubMed  CAS  Google Scholar 

  • Cutlip RC, Lehmkuhl HD, Jackson TA (1981) Intrauterine transmission of ovine progressive penumonia virus. Am J Vet Res 42: 1795–1797

    PubMed  CAS  Google Scholar 

  • Dawson M, Wilesmith JW (1985) Serological survey of lentivirus (maedi-visna/caprine arthritis-encephalitis) infection in British goat herds. Vet Rec 117: 86–89

    Article  PubMed  CAS  Google Scholar 

  • DeMartini JC, Banks KL, Greenlee A, Adams DS, McGuire TC (1983) Augmented T lymphocyte responses and abnormal B lymphocyte numbers in goats chronically infected with the retrovirus causing caprine arthritis-encephalitis. Am J Vet Res 44: 2064–2069

    PubMed  CAS  Google Scholar 

  • East NE, Rowe JD, Madewell BR, Floyd K (1987) Serologic prevalence of caprine arthritisencephalitis virus in California goat dairies. J Am Vet Med Assoc 190: 182–186

    PubMed  CAS  Google Scholar 

  • Ellis T, Robinson W, Wilcox G (1983a) Characterisation, experimental infection and serological response to caprine retrovirus. Aust Vet J 60: 321–326

    Article  PubMed  CAS  Google Scholar 

  • Ellis T, Robinson W, Wilcox G (1983b) Effect of colostrum deprivation of goat kids on the natural transmission of caprine retrovirus infection. Aust Vet J 60: 326–329

    Article  PubMed  CAS  Google Scholar 

  • Ellis TM, Carman H, Robinson WF, Wilcox GE (1986) The effect of colostrum-derived antibody on neo-natal transmission of caprine arthritis-encephalitis virus infection. Aust Vet J 63: 242–245

    Article  PubMed  CAS  Google Scholar 

  • Ellis TM, Wilcox GE, Robinson WF (1987) Antigenic variation of caprine arthritis-encephalitis virus during persistent infection of goats. J Gen Virol 68: 3145–3152

    Article  PubMed  Google Scholar 

  • Ellis TM, Robinson WF, Wilcox GE (1988) The pathology and aetiology of lung lesions in goats infected with caprine arthritis-encephalitis virus. Aust Vet J 65: 69–73

    Article  PubMed  CAS  Google Scholar 

  • Fisher AG, Ratner L, Mitsuya H, Marselle LM, Harper ME, Broder S, Gallo RC, Wong-Staal F (1986) Infectious mutants of HTLV-III with changes in the 3’ region and markedly reduced cytopathic effects. Science 233: 655–659

    Article  PubMed  CAS  Google Scholar 

  • Gates NL, Winward LD, Gorham JR, Shen DT (1978) Serologic survey of prevalence of ovine progressive pneumonia in Idaho range sheep. J Am Vet Med Assoc 173: 1575–1577

    PubMed  CAS  Google Scholar 

  • Gendelman HE, Narayan O, Molineaux S, Clements JE, Ghotbi Z (1985) Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow. Proc Natl Acad Sci USA 82: 7086–7090

    Article  PubMed  CAS  Google Scholar 

  • Gogolewski RP, Adams DS, McGuire TC, Banks KL, Cheevers WP (1985) Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive penumonia viruses involves all virion-associated proteins and glycoproteins. J Gen Virol 66: 1233–1240

    Article  PubMed  CAS  Google Scholar 

  • Gutekunst DE, Becvar CS (1979) Responses in horses infected with equine infectious anemia virus adapted to tissue culture. Am J Vet Res 40: 974–977

    PubMed  CAS  Google Scholar 

  • Haase A, Stowring L, Narayan O, Griffin D, Price D (1977) Slow persistent infection caused by visna virus: role of host restriction. Science 195: 175–177

    Article  PubMed  CAS  Google Scholar 

  • Houwers DJ, König CDW, deBoer GF, Schaake J (1983) Maedi-visna control in sheep. I. Artificial rearing of colostrum-deprived lambs. Vet Microbiol 8: 179–185

    Google Scholar 

  • Huso DL, Narayan O, Hart GW (1988) Sialic acids on the surface of caprine arthritis-encephalitis virus define the biological properties of the virus. J Virol 62: 1974–1980

    PubMed  CAS  Google Scholar 

  • Johnson GC, Adams DS, McGuire TC (1983a) Pronounced production of polyclonal immunoglobulin G1 in the synovial fluid of goats with caprine arthritis-encephalitis virus infection. Infect Immun 41: 805–815

    PubMed  CAS  Google Scholar 

  • Johnson GC, Barbet AF, Klevjer-Anderson P, McGuire TC (1983b) Preferential immune response to virion surface glycoproteins by caprine arthritis-encephalitis virus-infected goats. Infect Immun 41: 657–665

    PubMed  CAS  Google Scholar 

  • Klevjer-Anderson P, Anderson LW (1982) Caprine arthritis-encephalitis virus infection of caprine monocytes. J Gen Virol 58: 195–198

    Article  PubMed  Google Scholar 

  • Klevjer-Anderson P, McGuire TC (1982) Neutralizing antibody response of rabbits and goats to caprine arthritis-encephalitis virus. Infect Immun 38: 455–461

    PubMed  CAS  Google Scholar 

  • Klevjer-Anderson P, Adams DS, Anderson LW, Banks KL, McGuire TC (1984) A sequential study of virus expression in retrovirus-induced arthritis of goats. J Gen Virol 65: 1519–1525

    Article  PubMed  Google Scholar 

  • Kono Y, Kobayashi K, Fukunaga Y (1973) Antigenic drift of equine infectious anemia virus in chronically infected horses. Arch Gesamte Virusforsch 41: 1–10

    Article  PubMed  CAS  Google Scholar 

  • Koyanagi Y, Miles S, Mitsuyasu RT, Merrill JE, Vinters HV, Chen ISY (1987) Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236: 819–822

    Article  PubMed  CAS  Google Scholar 

  • Lairmore MD, Rosadio RH, DeMartini JC (1986) Ovine lentivirus lymphoid interstitial pneumonia. Rapid induction in neonatal lambs. Am J Pathol 125: 173–181

    PubMed  CAS  Google Scholar 

  • Lairmore MD, Akita GY, Russell HI, DeMartini JC (1987) Replication and cytopathic effects of ovine lentivirus strains in alveolar macrophages correlate with in vivo pathogenicity. J Virol 61: 4038–4042

    PubMed  CAS  Google Scholar 

  • Lairmore MD, Poulson JM, Adducci TA, DeMartini JC (1988) Lentivirus-induced lymphoproliferative disease. Comparative pathogenicity of phenotypically distinct ovine lentivirus strains. Am J Pathol 130: 80–90

    PubMed  CAS  Google Scholar 

  • Lutley R, Pétursson G, Pâlsson PA, Georgsson G, Klein J, Nathanson N (1983) Antigenic drift in visna: virus variation during long-term infection of Icelandic sheep. J Gen Virol 64: 1433–1440

    Article  PubMed  Google Scholar 

  • MacDiarmid SC (1984) Scheme to accredit flocks free from caprine arthritis encephalitis infection. NZ Vet J 32: 165–171

    Article  CAS  Google Scholar 

  • McGuire TC, Adams DS, Johnson GC, Klevjer-Anderson P, Barbee DD, Gorham JR (1986) Acute arthritis in caprine arthritis-encephalitis virus challenge exposure of vaccinated or persistently infected goats. Am J Vet Res 47: 537–540

    PubMed  CAS  Google Scholar 

  • McGuire TC, Brassfield AL, Davis WC, Cheevers WP (1987) Antigenic and structural variation of the p28 core polypeptide of goat and sheep retroviruses. J Gen Virol 68: 2259–2263

    Article  PubMed  CAS  Google Scholar 

  • McGuire TC, Norton LK, O’Rourke KI, Cheevers WP (1988) Antigenic variation of neutralizationsensitive epitopes of caprine arthritis-encephalitis lentivirus during persistent arthritis. J Virol 62: 3488–3492

    PubMed  CAS  Google Scholar 

  • Montelaro RC, Parekh B, Orrego A, Issel CJ (1984) Antigenic variation during persistent infection by equine infectious anemia virus, a retrovirus. J Biol Chem 259: 10539–10544

    PubMed  CAS  Google Scholar 

  • Narayan O, Cork LC (1985) Lentiviral diseases of sheep and goats: chronic pneumonia, leukoencephalomyelitis and arthritis. Rev Infect Dis 7: 89–98

    Article  PubMed  CAS  Google Scholar 

  • Narayan O, Griffin DE, Chase J (1977) Antigenic shift of visna virus in persistently infected sheep. Science 197: 376–378

    Article  PubMed  CAS  Google Scholar 

  • Narayan O, Griffin DE, Clements JE (1978) Visna mutation during `slow infection’: temporal development and characterization of mutants of visna virus recovered from sheep. J Gen Virol 41: 343–352

    Article  PubMed  CAS  Google Scholar 

  • Narayan O, Clements JE, Strandberg JD, Cork LC, Griffin DE (1980) Biological characterization of the virus causing leukoencephalitis and arthritis in goats. J Gen Virol 50: 69–79

    Article  PubMed  CAS  Google Scholar 

  • Narayan O, Kennedy-Stoskopf S, Sheffer D, Griffin DE, Clements JE (1983) Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages. Infect Immun 41: 67–73

    PubMed  CAS  Google Scholar 

  • Narayan O, Sheffer D, Griffin DE, Clements J, Hess J (1984) Lack of neutralizing antibodies to caprine arthritis-encephalitis lentivirus in persistently infected goats can be overcome by immunization with inactivated Mycobacterium tuberculosis. J Virol 49: 349–355

    PubMed  CAS  Google Scholar 

  • Norman S, Smith MC (1983) Caprine arthritis-encephalitis: review of the neurologic form in 30 cases. J Am Vet Med Assoc 182: 1342–1345

    PubMed  CAS  Google Scholar 

  • Oliver RE, Gorham JR, Perryman LE, Spencer GR (1981) Ovine progressive pneumonia: experimental intrathoracic, intracerebral, and intra-articular infections. Am J Vet Res 42: 1560–1564

    PubMed  CAS  Google Scholar 

  • O’Sullivan BM, Eaves FW, Baxendell SA, Rowan KJ (1978) Leucoencephalomyelitis of goat kids. Aust Vet J 54: 479–483

    Article  PubMed  Google Scholar 

  • Payne SL, Fang FD, Liu CP, Dhruva BR, Rwambo P, Issel CJ, Montelaro RC (1987) Antigenic variation and lentivirus persistence: variations in envelope gene sequences during EIAV infection resemble changes reported for sequential isolates of HIV. Virology 161: 321–333

    Article  PubMed  CAS  Google Scholar 

  • Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P (1988) The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 239: 586–592

    Article  PubMed  CAS  Google Scholar 

  • Pyper JM, Clements JE, Molineaux SM, Narayan O (1984) Genetic variation among lentiviruses: homology between visna virus and caprine arthritis-encephalitis virus is confined to the 5’ gag-pol region and a small portion of the env gene. J Virol 51: 713–721

    PubMed  CAS  Google Scholar 

  • Pyper JM, Clements JE, Gonda MA, Narayan O (1986) Sequence homology between cloned caprine arthritis encephalitis virus and visna virus, two neurotropic lentiviruses. J Virol 58: 665–670

    PubMed  CAS  Google Scholar 

  • Roberson SM, Cheevers WP (1984) A physical map of caprine arthritis-encephalitis provirus. Virology 134: 489–492

    Article  PubMed  CAS  Google Scholar 

  • Robinson WF, Ellis TM (1986) Caprine arthritis-encephalitis virus infection: from recognition to eradication. Aust Vet J 63: 237–241

    Article  PubMed  CAS  Google Scholar 

  • Scott JV, Stowring L, Haase AT, Narayan O, Vigne R (1979) Antigenic variation in visna virus. Cell 18: 321–327

    Article  PubMed  CAS  Google Scholar 

  • Sims LD, Hale CJ, McCormick BM (1983) Progressive interstitial pneumonia in goats. Aust Vet J 60: 368–371

    Article  PubMed  CAS  Google Scholar 

  • Smith VW, Dickson J, Coackley W, Maker D (1981) Caprine syncytial retroviruses. Aust Vet J 57: 481–483

    Article  PubMed  CAS  Google Scholar 

  • Sodroski J, Rosen C, Wong-Staal F, Salahuddin SZ, Popovic M, Arya S, Gallo RC, Haseltine WA (1985) Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science 227: 171–173

    Article  PubMed  CAS  Google Scholar 

  • Sonigo P, Alizon M, Staskus K, Klatzmann D, Cole S, Danos O, Retzel E, Toillais P, Haase A, Wain-Hobson S (1985) Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus. Cell 42: 369–382

    Article  PubMed  CAS  Google Scholar 

  • Sundquist B, Jönsson L, Jacobsson SO, Hammarberg KE (1981) Visna virus meningoencephalomyelitis in goats. Acta Vet Scand 22: 315–330

    PubMed  CAS  Google Scholar 

  • Surman PG, Daniels E, Dixon BR (1987) Caprine arthritis-encephalitis virus infection of goats in South Australia. Aust Vet J 64: 266–269

    Article  PubMed  CAS  Google Scholar 

  • Thormar H, Barshatzky MR, Arnesen K, Kozlowski PB (1983) The emergence of antigenic variants is a rare event in long-term visna virus infection in vivo. J Gen Virol 64: 1427–1432

    Article  PubMed  Google Scholar 

  • Woodard JC, Gaskin JM, Poulos PW, MacKay RJ, Burridge MJ (1982) Caprine arthritisencephalitis: clinicopathologic study. Am J Vet Res 43: 2085–2096

    PubMed  CAS  Google Scholar 

  • Zwahlen R, Aeschbacher T, Baker M, Stucki M, Wyder-Walter M, Weiss M, Steck F (1983) Lentivirus Infektionen bei Ziegen mit Carpitis and interstitieller Mastitis. Schweiz Arch Tierheilkd 125: 281–299

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164, USA

    T. C. McGuire, K. I. O’Rourke, D. P. Knowles & W. P. Cheevers

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  1. T. C. McGuire
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  2. K. I. O’Rourke
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  3. D. P. Knowles
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  4. W. P. Cheevers
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Editors and Affiliations

  1. Dept. of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 N. Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone M.D.

  2. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski M.D. (Direktor) (Direktor)

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© 1990 Springer-Verlag Berlin · Heidelberg

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McGuire, T.C., O’Rourke, K.I., Knowles, D.P., Cheevers, W.P. (1990). Caprine Arthritis Encephalitis Lentivirus Transmission and Disease. In: Oldstone, M.B.A., Koprowski, H. (eds) Retrovirus Infections of the Nervous System. Current Topics in Microbiology and Immunology, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75267-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-75267-4_4

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