Abstract
The class I transplantation antigens encoded in the major-histocompatibility complex (MHC) (HLA-A, -B, -C in man, H-2K, -D, -L in mouse) are expressed at the surface of most somatic cells of the organism as heterodimers of a polymorphic 43,000 to 45,000 M.W. glycoprotein non-covalently associated with an invariant 12,000 M.W. light chain called ß 2-microglobulin ß 2-m)(Ploegh et. al., 1981; Klein, 1986). Class I gene expression has been demonstrated to be regulated during embryonic development (Ozato et. al., 1985), between tissues in the adult (Harris et. al., 1986; Halloran et. al., 1986), and in response to various lymphokines and viruses (Harris et. al., 1986; Halloran et. al., 1986). The primary function of these molecules is in the presentation of foreign antigens to CD8-positive cytotoxic T lymphocytes (Klein, 1986).
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Chamberlain, J.W., Conrad, P.J., Weissmann, S.M. (1990). Regulation of Expression of Human MHC Class I Heavy (HLA-B7) and Light (hβ 2-m) Chain Genes in Transgenic Mice. In: Egorov, I.K., David, C.S. (eds) Transgenic Mice and Mutants in MHC Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75442-5_17
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DOI: https://doi.org/10.1007/978-3-642-75442-5_17
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