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The Fibroblast Growth Factors: An Emerging Family of Neural Growth Factors

  • Chapter
Neuronal Growth Factors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 165))

Abstract

The fibroblast growth factors (FGFs) are a family of peptide growth factors that share a number of biochemical and biological properties. The FGFs were originally identified as peptides containing mitogenic activity for fibroblasts and existing at high levels in brain extracts (Gospodarowlcz 1974). We now know that the members of the FGF gene family can regulate a number of distinct biological activities. The group of proteins that are known as the FGFs has been discovered, rediscovered, and purified under a number of different names reflecting either the tissue of origin or the biological activity that was used to monitor their purification (for a partial list see Gosrodarowicz et al. 1987). From the work of a number of laboratories dating from 1983, it as now become apparent that members of the FGF family, in addition to their other biological effects, are potent neural growth factors that have specific effects on the division, differentiation, and survival of specific classes of nerve cells. This review will focus on the effects of the FGFs on nerve cells, but the reader should clearly be aware that these peptides affect a number of other cell types and that a meaningful understanding of their role in development and differentiation can occur only in the context of the constellation of effects under control of these molecules.

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Authors and Affiliations

  1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Division of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA, 02115, USA

    J. A. Wagner

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  1. J. A. Wagner
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  1. Department of Physiology and Biophysics, University of Washington, 98195, Seattle, WA, USA

    Mark Bothwell MD

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© 1991 Springer-Verlag Berlin · Heidelberg

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Wagner, J.A. (1991). The Fibroblast Growth Factors: An Emerging Family of Neural Growth Factors. In: Bothwell, M. (eds) Neuronal Growth Factors. Current Topics in Microbiology and Immunology, vol 165. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75747-1_6

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  • DOI: https://doi.org/10.1007/978-3-642-75747-1_6

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