Abstract
Transcriptional activation of cellular oncogenes has been shown to be associated with the integration of replication-competent retroviruses in a variety of tumors. Activation of the c-myc oncogene by viral integration within or near the gene has been shown to occur in several tumor systems including bursal B-cell lymphomas of the chicken and murine T-cell lymphomas.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Asselin C, Nepveu A, Marcu KB (1989) Molecular requirements for transcriptional initiation of the murine c-myc gene. Oncogene 4: 549–558.
Clurman B, Hayward W (1988) Insertional activation of proto-oncogenes. In Cellular Oncogene Activation. G. Klein ed. pp. 55–94.
Goodnow MM, Hayward WS (1987) 5′ long terminal repeats of myc associated proviruses appear structurally intact but are functionally mpaired in tumors induced by avian leukosis virus. J Virology 621: 2489–2498.
Kakkis E, Riggs KJ, Gillespie W, Calame K (1989) A transcriptional repressor of c-myc. Nature 339: 718–722.
Mushinski JF, Skurla RM Jr, Goodnight J, Siwarski D, Huppi K Expression of c-myc and Pvt-1. Curr Top Micro Immunol (this volume).
Nepveu A, and Marcu K (1986) Intragenic pausing and anti-sense transcription within the murine c-myc locus. EMBO 5: 2859–2865.
Ohno S, Migita S, Wiener F, Babonits, M, Klein G, Mushinski J F, Potter M (1984) Chromosomal translocations activating myc sequences and plasmacytomas by pristane and Abelson virus. J Exp Med 159: 1762–777.
Potter M (1990) Neoplastic development in B-lymphocytes Carcinogenesis 11: 1–13.
Remmers E, Yang J, Marcu K (1986) A negative transcriptional control element located upstream of the murine c-myc gene. EMBO 5: 899–904.
Yang JQ, Remmers EF, Marcu KB (1986) The first exon of the c-myc proto-oncogene contains a novel positive control element. EMBO 5: 3553–3562.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Shaughnessy, J., Huppi, K., Mushinski, J.F., Potter, M. (1990). Moloney Murine Leukemia Virus Integration 1060 Base Pairs 5’ of c-myc Exon 1 in a Plasmacytoma Without a Chromosomal Translocation. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1990. Current Topics in Microbiology and Immunology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75889-8_37
Download citation
DOI: https://doi.org/10.1007/978-3-642-75889-8_37
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75891-1
Online ISBN: 978-3-642-75889-8
eBook Packages: Springer Book Archive