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Experimental Manipulation of the Blood-Brain ”and Blood-Retinal Barriers

  • Chapter
Physiology and Pharmacology of the Blood-Brain Barrier

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 103))

Abstract

There exists two major areas of research in which experimental manipulation of the blood-brain barrier (BBB) and blood-retinal barrier (BRB) are routinely employed. Firstly, there are a broad range of investigations undertaken to elucidate the various cellular mechanisms involved in precipitating both the structural and fuctional alterations of the barrier often found in diseases of the central nervous system (CNS). Secondly, there are those studies involved in the discovery and characterisation of agents capable of disrupting the integrity of the BBB and BRB with the ultimate aim of developing a safe method for enhancing the delivery of therapeutic agents to the CNS.

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Abbreviations

ADP:

Adenosine diphosphate

AMP:

Adenosine monophosphate

ATP:

Adenosine triphosphate

BBB:

Blood-brain barrier

BRB:

Blood-retinal barrier

cAMP:

Cyclic AMP

CNS:

Central nervous system

DMSO:

Dimethyl sulphoxide

HRP:

Horseradish peroxidase

5-HT:

5-hydroxytryptamine

IL:

Interleukin

LAK:

Lymphokine-activated killer

MIP:

Macrophage inflammatory protein

PAF:

Platelet activating factor

TCDC:

Taurochenodeoxycholate

TNF:

Tumour necrosis factor

VPF:

Vascular permeability factor

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Authors
  1. J. Greenwood
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  1. Physiology Group Biomedical Sciences Division King’s College London, University of London, Strand, WC2R 2LS, London, Great Britain

    Michael W. B. Bradbury M.A., D.M. (Oxon)

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© 1992 Springer-Verlag Berlin Heidelberg

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Greenwood, J. (1992). Experimental Manipulation of the Blood-Brain ”and Blood-Retinal Barriers. In: Bradbury, M.W.B. (eds) Physiology and Pharmacology of the Blood-Brain Barrier. Handbook of Experimental Pharmacology, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76894-1_19

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  • DOI: https://doi.org/10.1007/978-3-642-76894-1_19

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  • Print ISBN: 978-3-642-76896-5

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