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On the Role of Endogenously Produced TNF-α and IL-6 as Regulators of Growth and Differentiation of B-Type Chronic Lymphocytic Leukemia Cells In Vitro

  • Chapter
Mechanisms in B-Cell Neoplasia 1992

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 182))

Abstract

Chronic lymphocytic leukemia of CD5+ B cells is clinically a heterogeneous disease [1]. This heterogeneity is also easily demonstrable in vitro [2]. In the vast majority of the cases B-CLL is a malignancy of CD5+ B cells with a very low capacity for proliferation in peripheral blood and with a phenotype resembling that of virgin [2] and mantle zone memory [3] B cells. In some cases the stage of differentiation is more advanced, as reflected by the capacity of the leukemic cells to secrete immunoglobulin [Ig]. In other rare cases Ig production may be very low and undetectable by immunofluorescence. The possibility that B-CLL might be a disease of differentiating leukemic B cells has not been extensively studied, but our own unpublished observations suggest that the stage of differentiation of the B-CLL cells may be different in peripheral lymphoid organs and in the bone marrow of the patient than in the peripheral blood, and the capacity for proliferation seems often to be about a 10-fold higher in these tissues.

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Author information

Authors and Affiliations

  1. Laboratory of Tumor Biology, Department of Pathology, Uppsala University, Uppsala, Sweden

    K. Nilsson, L.-G. Larsson, O. Söderberg & M. Carlsson

  2. Dipartimento di Scienze Biomediche e Oncologia Umana, Sezione Clinica, Università di Torino, Torino, Italy

    M. Schena, D. Gottardi & F. Caligaris-Cappio

Authors
  1. K. Nilsson
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  2. L.-G. Larsson
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  3. O. Söderberg
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  4. M. Schena
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  5. D. Gottardi
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  6. F. Caligaris-Cappio
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  7. M. Carlsson
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute National Institutes of Health, Bldg. 37, Rm 2B04, Bethesda, MD, 20892, USA

    Michael Potter M. D (Chief) (Chief)

  2. Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    Fritz Melchers (Director) (Director)

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© 1992 Springer-Verlag Berlin Heidelberg

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Nilsson, K. et al. (1992). On the Role of Endogenously Produced TNF-α and IL-6 as Regulators of Growth and Differentiation of B-Type Chronic Lymphocytic Leukemia Cells In Vitro. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_33

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  • DOI: https://doi.org/10.1007/978-3-642-77633-5_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77635-9

  • Online ISBN: 978-3-642-77633-5

  • eBook Packages: Springer Book Archive

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