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Proteolytic Inactivation of Neurohormonal Peptides in the Gastrointestinal Tract

  • Chapter
Gastrointestinal Regulatory Peptides

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 106))

Abstract

The gastrointestinal tract is a major site of production and inactivation of neurohormonal peptides. While biochemical and morphological aspects of the synthesis of gastrointestinal peptides have been studied in detail, relatively little work has been done to investigate the mechanisms by which these peptides are degraded following release. The neurohormonal peptides discussed in this article have different cellular distributions both along and within the different layers of the stomach and gut. Consequently, an analysis of the mechanisms by which these peptides are inactivated must take into account the microenvironment into which they are released.

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  1. J. M. Conlon
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Editors and Affiliations

  1. Department of Veterinary Biology, Pharmacology Section, University of Minnesota, 1988 Fitch Avenue, Saint Paul, MN, 55108, USA

    David R. Brown Ph.D.

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Conlon, J.M. (1993). Proteolytic Inactivation of Neurohormonal Peptides in the Gastrointestinal Tract. In: Brown, D.R. (eds) Gastrointestinal Regulatory Peptides. Handbook of Experimental Pharmacology, vol 106. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77814-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-77814-8_6

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