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Abnormal Calcium Metabolism in Heart Muscle Dysfunction

  • Conference paper
Idiopathic Dilated Cardiomyopathy

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Abstract

The clinical demonstration that contractile function is depressed in failing human hearts resulted in several logical corollaries to explain the pathophysiology of heart failure. Only recently have investigators been able to study human myocardium as opposed to making extrapolations from animal studies. As a result of these studies several hypotheses have been dispelled and the inappropriateness of certain animal models eluded to. However, there are limitations to human studies. When studying human myocardium one is often left with studying only one point in time. Further, one is left with the question of whether one is studying a mechanism of the disease, an adaptive response to the disease, or changes in response to the varied pharmacological treatments. Therefore mechanisms involved in the pathogenesis or natural history of the disease process cannot be easily investigated. Furthermore, one is often left studying an end-stage process that may or may not be reflective of the disease process. Nevertheless, despite these limitations studies involving human myocardium have yielded important information regarding pathophysiology as well as markers of the disease state.

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Authors
  1. J. K. Gwathmey
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  2. R. J. Hajjar
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Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik, Postfach 3742, W-3400, Göttingen, Fed. Rep. of Germany

    Hans-Reiner Figulla

  2. Institut für Pathologie, Universität Tübingen, W-7400, Tübingen, Fed. Rep. of Germany

    Reinhard Kandolf

  3. Max-Planck-Institut für Biochemie, W-8033, Martinsried, Fed. Rep. of Germany

    Reinhard Kandolf

  4. Department of Pathology and Microbiology, University of Nebraska, Medical Center, 600 South 42nd Street, Omaha, NE, 68198-6495, USA

    Bruce McManus Ph.D., M.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Gwathmey, J.K., Hajjar, R.J. (1993). Abnormal Calcium Metabolism in Heart Muscle Dysfunction. In: Figulla, HR., Kandolf, R., McManus, B. (eds) Idiopathic Dilated Cardiomyopathy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77891-9_13

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  • DOI: https://doi.org/10.1007/978-3-642-77891-9_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77893-3

  • Online ISBN: 978-3-642-77891-9

  • eBook Packages: Springer Book Archive

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