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Regulation of Cellular Phenotype in the Nociceptive Pathway

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Cellular Mechanisms of Sensory Processing

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References

  1. Abbadie, C. and Besson, J. (1993) Effects of morphine and naloxone on basal and evoked Fos-like immunoreactivity in lumbar spinal cord neurons of arthritic rats. Pain 52, 29–39.

    Article  PubMed  CAS  Google Scholar 

  2. Baraniuk, J.N., Kowalski, M.L., and Aliner, M.A. (1990) Relationship between permeable vessels, nerves, and mast cells in rat cutaneous neurogenic inflammation. J. Appl. Physiol. 68, 2305–2311.

    PubMed  CAS  Google Scholar 

  3. Barber, A. and Gottschlich, R. (1992) Opioid agonists and antagonists: an evaluation of their peripheral actions in inflammation. Med. Res. Rev. 12, (1992) 525–562.

    Article  PubMed  CAS  Google Scholar 

  4. Barron, B.A., Pierzchala K. and Van Loon G.R. (1990) Source of stress-induced increase in plasma met-enkephalin in rats: contribution of adrenal medulla and/or sympathetic nerves. J. Neuroendocrinol. 2, 381–388.

    Article  PubMed  CAS  Google Scholar 

  5. Bette, M., Schafer, M.K.-H., Van Rooijen, N. and Weihe, E. (1993) Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen, (in press).

    Google Scholar 

  6. Chen, Y., Mestek, A., Liu, J., Hurley, J.A. and Yu, L. (1993) Molecular cloning and functional expression of a µ-opioid receptor from rat brain. Mol. Pharmacol. 44, (in press).

    Google Scholar 

  7. Cintra, A., Fuxe, K., Solfrini, V., Agnati, L.F., Tinner, B., Wikstrom, A., Staines, W., Okret, S. and Gustafsson, J. (1991) Central peptidergie neurons as targets for glucocorticoid action. Evidence for the presence of glucocorticoid receptor immunoreactivity in various types of classes of peptidergic neurons, J. Steroid Biochem. Mol. Biol. 40, 93–103.

    Article  PubMed  CAS  Google Scholar 

  8. Coderre, T.J., Katz, J., Vaccarino, A.L. and Melzack, R. (1993) Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52, 259–285.

    Article  PubMed  CAS  Google Scholar 

  9. Cunha, F.Q., Lorenzetti, B.B., Poole, S. and Ferreira, S.H., Interleukin-8 as a mediator of sympathetic pain. Br. J. Pharmacol. 104, 765–767.

    Google Scholar 

  10. Dubner, R. and Ruda, M. A. (1992) Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15, 96–103.

    Article  PubMed  CAS  Google Scholar 

  11. Duggan, A.W. and Weihe, E. (1991) Central transmission of impulses in nociceptors: events in the superficial dorsal horn. In: Towards a new pharmacotherapy of pain. eds. A. I. Basbaum and J. Besson. John Wiley & Sons Ltd, Chichester, pp. 35–67.

    Google Scholar 

  12. Evans, C. J., Keith, JR., D. E., Morrison, H., Magendzo, K. and Edwards. R. H. (1992) Cloning of a delta opioid receptor by functional expression. Science 258, 1952–1955.

    CAS  Google Scholar 

  13. Fleetwood-Walker, S.M., Parker, R.M.C., Munro, F.E., Young, M.R., Hope, P.J. and Mitchell, R. (1993) Evidence for a. role of NK-2 receptors in mediating brief nociceptive inputs to rat dorsal horn (laminae II-V) neurons, Eur. J. Pharmacol, (in press).

    Google Scholar 

  14. Freidin, M. and Kessler, J. A. (1991) Cytokine regulation of substance P expression in sympathetic neurons. Proc. Natl. Acad. Sci. USA 88, 3200–3203.

    Article  PubMed  CAS  Google Scholar 

  15. Gogas, K. R., Presley, R. W., Levine, J. D. and Basbaum, A. I. (1991) The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control; correlation of nociceptive behavior and c-fos expression. Neuroscience 42, 617–628.

    Article  PubMed  CAS  Google Scholar 

  16. Handwerker, H. O. (1991) What peripheral mechanisms contribute to nociceptive transmission and hyperalgesia? In: Towards a new pharmacotherapy of pain, eds.: A.I. Basbaum and J.-M. Besson. John Wiley & Sons Ltd, Chichester, pp. 5–19.

    Google Scholar 

  17. Hanesch, U., Heppelmann, B. and Schmidt, R. F. (1991) Substance P- and calcitonin gene-related peptide immunoreactivity in primary afferent neurons of the cat’s knee joint. Neuroscience 45, 185–193.

    Article  PubMed  CAS  Google Scholar 

  18. Harlan, R. E. (1988) Regulation of neuropeptide gene expression by steroid hormones. Mol. Neurobiol. 2, 183–200.

    Article  PubMed  CAS  Google Scholar 

  19. Hassan, A. H. S., Przewlocki, R., Herz, A. and Stein, C. (1992) Dynorphin, a preferential ligand for k-opioid receptors, is present in nerve fibers and immune cells within inflamed tissue of the rat. Neurosci. Lett, (in press).

    Google Scholar 

  20. Herdegen, T., Kovary, K., Leah, J. and Bravo, R. (1991) Specific temporal and spatial distribution of JUN, FOS, and KROX-24 proteins in spinal neurons following noxious transsynaptic stimulation. J. Comp. Neurol. 313, 178–91.

    Article  PubMed  CAS  Google Scholar 

  21. Hokfelt, T., Neuropeptides in perspective: The last ten years, Neuron, 7 (1991) 867–879.

    Article  PubMed  CAS  Google Scholar 

  22. Iadarola, M. J., Brady, L. S., Draisci, G. and Dubner, R. (1988) Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding. Pain 35, 313–326.

    Article  PubMed  CAS  Google Scholar 

  23. Janig, W. and McLachlan, E.M. (1992) Characteristics of function-specific pathways in the sympathetic nervous system. Trends in Neurosci. 15, 478–481.

    Article  Google Scholar 

  24. Johnson, H., Hokfelt, T. and Ulfhake, B. (1992) Galanin and CGRP-like immunoreactivity coexist in rat spinal motoneurons, NeuroReport 3, 303–306.

    Article  PubMed  CAS  Google Scholar 

  25. Jonat, C., Rahmsdorf, H.J., Park, K.-K., Caro, A.C.B., Gebel, S., Ponta, H. and Herrlich, P. (1990) Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62, 1189–1204.

    Article  PubMed  CAS  Google Scholar 

  26. Kar, S., Gibson, S. J., Rees, R. G., Jura, W. G., Brewerton, D. A. and Polak, J. M. (1991) Increased calcitonin gene-related peptide (CGRP), substance P, and enkephalin immunoreactivities in dorsal spinal cord and loss of CGRP-immunoreactive motoneurons in arthritic rats depend on intact peripheral nerve supply. J. Mol. Neurosci. 3, 7–18.

    Article  PubMed  CAS  Google Scholar 

  27. Kew, D. and Kilpatrick, D.L. (1990) Widespread organ expression of the rat proenkephalin gene during early postnatal development. Mol. Endocrinol. 4, 337–340.

    Article  PubMed  CAS  Google Scholar 

  28. Kieffer, B. L., Befort, K., Gavbriaux-Ruff, C. and Hirth, C. G. (1992) The d-opioid receptor: Isolation of a cDNA by ex The d-opioid receptor and pharmacological characterization. Proc. Natl. Acad. Sci. USA 89, 12048–12052.

    Article  PubMed  CAS  Google Scholar 

  29. Levine, D.J., Fields H.L. Sand Basbaum, A.I. (1993)Peptides and the primary afferent nociceptor. J. Neurosci. 13, 2273–2286.

    PubMed  CAS  Google Scholar 

  30. Lewine, G.R. and Mendell, L.M. (1993) Nerve growth factor and nociception. Trends Neurosci 16, 353–359.

    Article  Google Scholar 

  31. Lu, J., Hathaway, C.B., and Bereiter, D.A.,. (1993) Adrenalectomy enhances fos-like immunoreactivity within the spinal trigeminal nucleus induced by noxious thermal stimulation of the cornea. Neuroscience 54, 809–818.

    Article  PubMed  CAS  Google Scholar 

  32. Lucas, J.J., Mellstrom, B., Colado, M.I. and Naranjo, J.R. (1993) Molecular mechanisms of pain: Serotonin 1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons. Neuron 10, 599–611.

    Article  PubMed  CAS  Google Scholar 

  33. Maggi, C. A. (1991) The pharmacology of the efferent function of sensory nerves. J. Auton. Pharmac. 11, 173–208.

    Article  CAS  Google Scholar 

  34. McLachlan, E.M., Janig, W., Devor, M. and Michaelis, M. Peripheral Nerve Injury Triggers Noradrenergic Sprouting Within Dorsal Root Ganglia. Nature 363, 543–546.

    Google Scholar 

  35. Mearow, K.M., Kril, Y. and Diamond, J. (1993) Increased NGF mRNA expression in denervated rat skin. NeuroReport 4, 351–354.

    Article  PubMed  CAS  Google Scholar 

  36. Mechanik, J.I., Levin, N., Roberts, J.L and Autelitatno, D.J. (1992) Proopiomelanocortin gene expression in a distinct population of rat spleen and lung leukocytes. Endocrinology 131, 518–525.

    Article  Google Scholar 

  37. Millan, M. J., Multiple opioid systems and chronic pain. In: The opioids, ed.: A. Herz. Springer, Heidelberg, (in press).

    Google Scholar 

  38. Noguchi, K., Kowalski, K., Traub, R., Solodkin, A., Iadarola, M. J. and Ruda, M. A. (1991) Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons. Mol Brain Res. 10, 227–233.

    Article  PubMed  CAS  Google Scholar 

  39. Noguchi, K. and Ruda, M.A. (1992) Gene regulation in an ascending nociceptive pathway: inflammation-induced increase in preprotachykinin mRNA in rat lamina I projection neurons. J. Neurosci. 12, 2563–2572.

    PubMed  CAS  Google Scholar 

  40. Noguchi, K., De Leon, R.L., Nahin, E., Senba, E. and Ruda, M.A. (1993) Quantification of axotomy-induced alteration of neuropeptide mRNAs in dorsal root ganglion neurons with special reference to neuropetide Y mRNA and the effects of neonatal capsaicin treatment. J. Neurosci. Res. 35, 54–66.

    Article  PubMed  CAS  Google Scholar 

  41. Parker, R.M.C., Fleetwood-Walker, S.M., Rosie, R., Munro, F.E. and Mitchell, R. (1993) Inhibition by NK-2 but not NK1 antagonists of carrageenan-induced preprodynorphin expression in rat dorsal horn lamina I. Neuropeptides (In press).

    Google Scholar 

  42. Personn, E., Malherbe, P. and Richards, J. G., In situ hybridization histochemistry reveals a diversity of GABA receptor subunit mRNAs in neurons of the rat spinal cord and dorsal root ganglia, Neuroscience, 42 (1991)497–507.

    Article  Google Scholar 

  43. Persson, S., Post, C., Holmdahl, R. and Nyberg, F. (1992) Decreased neuropeptide-converting enzyme activities in cerebrospinal fluid during acute but not chronic phases of collagen induced arthritis in rats. Brain Res. 581, 273–282.

    Article  PubMed  CAS  Google Scholar 

  44. Plantinga, L.C., Verhaagen, J., Edwards, P.M., Schrama, L.H., Burbach J.P.H., and Gispen, W.H., Expression of the pro-opiomelanocortin

    Google Scholar 

  45. Presley, R. W., Menetrey, D., Levine, J. D. and Basbaum, A. I. (1990) Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J. Neurosci. 10, 323–335.

    PubMed  CAS  Google Scholar 

  46. Przewlocka, B., Lason, W. and Przewlocki, R. (1992) Time-dependent changes in the activity of opioid systems in the rat spinal cord of monoarthritic rats — a release and in situ hybridization study. Neuroscience 46, 209–216.

    Article  PubMed  CAS  Google Scholar 

  47. Przewlocki, R., Hassan. A. H. S., Lason, W., Epplen, C., Herz, A. and Stein, C. (1992) Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception. Neuroscience 48, 491–500.

    Article  PubMed  CAS  Google Scholar 

  48. Rogers, H., Birch, P.J., Harrison, S.M., Palmer, E., Manchee, G.R., Judd, D.B., Naylor, A., Scopes, D.I.C. and Hayes, A.G. (1992) GR94839, a kappa-opioid agonist with limited access to the central nervous system, has antinociceptive activity. Br. J. Pharmacol. 106, 783–789.

    PubMed  CAS  Google Scholar 

  49. Rosen, H., Polakiewicz, R.D., Benzakine, S. and Bar-Shavit, Z. (1991) Proenkephalin A in bone-derived cells. Proc. Natl. Acad. Sci. USA 88, 3705–3709.

    Article  PubMed  CAS  Google Scholar 

  50. Rusin, K. I., Ryu, P. D. and Randic, M. (1992) Modulation of excitatory amino acid responses in rat dorsal horn neurons by tachykinins. J. Neurophysiol. 68, 265–286.

    PubMed  CAS  Google Scholar 

  51. Schafer, M. K.-H., Day, R., Seidah, N., Chretien, M. and Weihe, E. (1992) Gene expression of novel prohormone convertases in the rat spinal cord. Neuropeptides 22, 59–60.

    Article  Google Scholar 

  52. Schafer, M. K.-H., Nohr, D., Krause, J. E. and Weihe, E. (1993) Unilateral peripheral inflammation upregulates tachykinin receptor gene expression in the ipsilateral dorsal horn of rat spinal cord. NeuroReport 4, 1007–1010.

    Article  PubMed  CAS  Google Scholar 

  53. Schafer, M.K.-H., Nohr, D., Romeo, H., Eiden, L.E. and Weihe, E. (1993) Pan-neuronal expression of chromogranin A in rat nervous system. Peptides (in press).

    Google Scholar 

  54. Shadiack, A.M., Hart, R.P., Carlson, C.D. and Miller Jonakeit, G. (1993) Interleukin-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitor factor (LIF). J. Neurosci. 13, 2601–2609.

    PubMed  CAS  Google Scholar 

  55. Stein, C., Gramsch, C. and Herz, A. (1990) Intrinsic mechanisms of antinociception in inflammation: local opioid receptors and p-endorphin. J. Neurosci. 10, 1292–1298.

    PubMed  CAS  Google Scholar 

  56. Smith, G.D., Seckl, J.R., Sheward, W.J., Bennie, J.G., Carroll S.M., Dick, H. and Harmar, A.J. (1991) Effect of adrenalectomy and dexamethasone on neuropeptide content of dorsal root ganglia in the rat. Brain Res. 564, 27–30.

    Article  PubMed  CAS  Google Scholar 

  57. Taiwo, Y. O., Levine, J. D., Burch, R. M., Woo, J. E. and Mobley, W. C. (1991) Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor. Proc. Natl. Acad. Sci. USA 88, 5144–5148.

    Article  PubMed  CAS  Google Scholar 

  58. Taquuet, H., Plachot, J.J. Pohl, M., Collin, E., Benoliel, J.J., Bourgoin, S., Mauborgne, A., Meunier, J.C., Cesselin, F. and Hamon, M. (1992) Increased calcitonin gene-related peptide- and cholecystokinin-like immunoreactivities in spinal motoneurones after dorsal rhizotomy. J. Neur. Transmiss. 88, 127–141.

    Article  Google Scholar 

  59. Thai, L., Lee, P. H. K., Ho, J., Suh, H. and Hong, J. S. (1992) Regulation of prodynorphin gene expression in the hippocampus by glucocorticoids. Mol. Brain Res. 16, 150–157.

    Article  PubMed  CAS  Google Scholar 

  60. Tolle, T. R., Castro-Lopes, J. M. and Zieglgansberger, W. (1991) C-fos induction in the spinal cord following noxious stimulation: prevention by opiates but not by NMDA antagonists. In: Proceedings of the VIth World Congress on Pain, eds: M. R. Bond, J. E. Charlton, and C. J. Woolf. Elsevier Science Publishers, Amsterdam, pp. 299–305.

    Google Scholar 

  61. Wahlestedt, C., Pich, E.M., Koob, G.F., Yee, F. and Heilig (1993) Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259, 528–531.

    Article  PubMed  CAS  Google Scholar 

  62. Weihe, E., Nohr, D., Michel, S., Muller, S., Zentel, H., Fink, T. and Krekel, J. (1991) Molecular anatomy of the neuro-immune connection. Intern. J. Neurosci. 59, 1–23.

    Article  CAS  Google Scholar 

  63. Weihe, E., Hartschuh, W. and Nohr, D. (1991) Light microscopic immunoenzyme and electron microscopic immunogold cytochemistry reveal tachykinin immuno-reactivity in Merkel cells of pig skin. Neurosci. Lett. 124, 260–263.

    Article  PubMed  CAS  Google Scholar 

  64. Weihe, E., Muller, S., Buchler, M., Friess, H. and Nohr, D. (1991) The tachykinin neuroimmune connection in inflammatory pain. In: Substance P and related peptides: cellular and molecular physiology, eds.: S. E. Leeman, J. E. Krause, and Lembeck, F. New York Academy of Sciences, New York, pp. 283–295.

    Google Scholar 

  65. Weihe, E. (1992) Neurochemical anatomy of the mammalian spinal cord: functional implications. Annals of Anatomy 174, 89–118.

    Article  PubMed  CAS  Google Scholar 

  66. Weihe, E., Schafer, M-K.-H., Persson, S., Nohr, D., Post, C., Ekstrom, G. and Nyberg, F. (1993) Glucocorticoids modulate basal and inflammation-induced opioid gene expression in rat spinal cord. Br. J. Pharmacol, (in press).

    Google Scholar 

  67. Weihe, E., Schafer, M.K.-H., Nohr, D. and Persson, S. (1993) Expression of neuropeptides, neuropeptide receptors and neuropeptide processing enzymes in spinal neurons and peripheral non-neural cells and plasticity in model of inflammatory pain, In: Neuropeptides, nociception and pain, eds.: Schmidt, R.F. and Schaible, H.G. V.C.H. Weinheim, ( In press ).

    Google Scholar 

  68. Winkler, H. and Fischer-Colbrie, R. (1992) The chromogranins A and B: the first 25 years and future perspestives, 49, 497–528.

    CAS  Google Scholar 

  69. Van Woudenberg, A.D., Metzelaar, M.J., Van Der Kleij, A. A. M., De Wied, D., Burbach, J.P.H. and Wiegant, V.M.(1993) Analysis of pro-opiomelanocortin (POMC) mRNA and POMC-derived peptides in human peripheral blood mononuclear cells: no evidence for a lymphocyte-derived POMC system, Endocrinology (in press).

    Google Scholar 

  70. Yasuda, K., Raynor, K., Kong, H., Breder, C.D., Takeda, J., Reisine, T. and Bell, G.I. (1993) Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc. Natl. Acad. Sci. USA 90, 6736–6740.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dept. of Anatomy, Johannes Gutenberg-University, D-55099, Mainz, Germany

    Eberhard Weihe & Martin K.-H. Schafer

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  1. Eberhard Weihe
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  2. Martin K.-H. Schafer
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Editors and Affiliations

  1. Sandoz Institute for Medical Research, 5 Gower Place, London, WC1E 6BN, UK

    Laszlo Urban

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Weihe, E., Schafer, M.KH. (1994). Regulation of Cellular Phenotype in the Nociceptive Pathway. In: Urban, L. (eds) Cellular Mechanisms of Sensory Processing. NATO ASI Series, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78762-1_21

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  • DOI: https://doi.org/10.1007/978-3-642-78762-1_21

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