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Molecular Mechanisms of Action of Antihypertensive Agents Ca-Antagonists and K-Channel Openers on Vascular Smooth Muscle

  • Chapter
Pharmacology of Smooth Muscle

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 111))

Abstract

The tone of the vascular wall of resistance vessels is one of the most important factors in the control of blood pressure, and is dependent upon the intracellular concentration of Ca ions. Several mechanisms are involved in changing the intracellular Ca concentration of vascular smooth muscle cells. One of the main mechanisms underlying the contraction of smooth muscle cells induced by neurotransmitters, such as noradrenaline and adenosine 5’-triphosphate (ATP), is thought to be the release of Ca ions from their intracellular store site (sarcoplasmic reticulum), which is initiated by the synthesis of inositol 1,4,5-trisphosphate through activation of phospholipase C coupled to the adrenergic and purinergic receptors. However, part of the contraction induced by these stimulants (the slow or sustained component of the contraction) has been suggested to be due to Ca influx through ion channels because removal of extracellular Ca ions inhibits it.

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  1. K. Kitamura
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  2. H. Kuriyama
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  1. Department of Pharmacology, Albert-Szent-Györgyi Medical University, Dóm tér 12, P.O. Box 115, H-6720, Szeged, Hungary

    Laszló Szekeres M.D., Ph.D., D.Sc. (Professor) & Julius Gy. Papp M.D., Ph.D., D.Sc. (Professor) (Professor) &  (Professor)

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© 1994 Springer-Verlag Berlin Heidelberg

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Kitamura, K., Kuriyama, H. (1994). Molecular Mechanisms of Action of Antihypertensive Agents Ca-Antagonists and K-Channel Openers on Vascular Smooth Muscle. In: Szekeres, L., Papp, J.G. (eds) Pharmacology of Smooth Muscle. Handbook of Experimental Pharmacology, vol 111. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78920-5_16

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  • DOI: https://doi.org/10.1007/978-3-642-78920-5_16

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