Abstract
The most popular hypothesis for how asbestos transforms cells is based on its physical dimensions, not its chemistry. This view is derived from the finding that the cytotoxic effects and transforming ability of various mineral fibers are related primarily to fiber dimensions (i.e., the length/width aspect ratio — See Hesterberg and Barrett, 1984; Stanton et al 1981; reviewed in Harington, 1981). For this reason, a knowledge of how mineral fibers behave within interphase and dividing cells, and with what intracellular components they interact, becomes important in elucidating the mechanism(s) by which they cause cell injury.
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Jensen, C.G., Jensen, L.C.W., Ault, J.G., Osorio, G., Cole, R., Rieder, C.L. (1994). Time-Lapse Video Light Microscopic and Electron Microscopic Observations of Vertebrate Epithelial Cells Exposed to Crocidolite Asbestos. In: Davis, J.M.G., Jaurand, MC. (eds) Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres. NATO ASI Series, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79041-6_6
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DOI: https://doi.org/10.1007/978-3-642-79041-6_6
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