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Biochemical Mechanisms of Aluminum Toxicity

  • Chapter
Toxicology of Metals

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 115))

Abstract

In considering Al1 toxicity, one is struck by the normally successful exclusion of this ubiquitous element from animal tissues. Al is the third most prevalent element in the world, naturally present in air, soil, and water. In addition, Al enjoys a GRAS (Generally Regarded As Safe) rating by the FDA, allowing unregulated addition not only to most municipal water supplies, but to many processed foods and medications. Even with such wide exposure, tissue Al levels are normally very low. Under the unusual conditions where tissue Al levels start to rise, several distinct lesions, including an encephalopathy, osteodystrophy, and anemia are seen to occur. Some tissues accumulate Al more readily than others. Whether Al has one dominant effect, with organ selectivity of lesions accounted for by the uneven Al accumulation, or several organ-specific effects on cellular biochemistry, is yet to be determined. Several reviews on Al toxicity focus on bioavailability (e.g., DE VOto and YOkel 1994; VAn DEr VOet 1992b), but few focus on biochemical mechanisms of toxicity (EXley and BIrchall 1992; ABreo and GLass 1993).

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References

  • Abdel-Ghany M, El-Sebae AK, Shalloway D (1993) Aluminum-induced nonenzymatic phosphoincorporation into human tau and other proteins. J Biol Chem 11976–11981

    Google Scholar 

  • Abreo K, Glass J (1993) Cellular, biochemical, and molecular mechanisms of aluminium toxicity. Nephrol Dial Transplant [Suppl] 1:5–11

    Google Scholar 

  • Abreo K, Glass J, Sella M (1990) Aluminum inhibits hemoglobin synthesis but enhances iron uptake in Friend erythroleukemia cells. Kidney Int 37:677–681

    PubMed  CAS  Google Scholar 

  • Abreo K, Jangula J, Jain SK, Sella M, Glass J (1991) Aluminum uptake and toxicity in cultured mouse hepatocytes. J Am Soc Nephrol 1:1299–1304

    PubMed  CAS  Google Scholar 

  • Adler AJ, Berlyne GM (1985) Duodenal aluminum absorption in the rat: effect of vitamin E. Gastrointest Liver Physiol 12:G209–G213

    Google Scholar 

  • Ahn HW, Futton B, Moxon D, Jeffery EH (1994) The interactive effects of Fluoride and Aluminum Uptake and accumulation in bones of rabbits administered both agents in their drinking water. Toxicol Environ Health (in press)

    Google Scholar 

  • Alfrey AC, LeGendre GR, Kaehny WD (1976) The dialysis encephalopathy syndrome. Possible aluminium intoxication. N Engl J Med 294:184–188

    PubMed  CAS  Google Scholar 

  • Antonny B, Chabre M (1992) Characterization of the aluminum and beryllium fluoride species which activate transducin. J Biol Chem 267:6710–6718

    PubMed  CAS  Google Scholar 

  • Antonny B, Sukumar M, Bigay J, Chabre M, Higashijima T (1993) The mechanism of aluminum-independent G-protein activation by fluoride and magnesium. J Biol Chem 268:2393–2402

    PubMed  CAS  Google Scholar 

  • Berlyne GM, Yagil R (1973) Aluminum induced porphyria in rats. Lancet ii:1502–1503

    Google Scholar 

  • Bigay J, Deterre P, Pfister C, Chabre M (1987) Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the γ phosphate of GTP. EMBO J 6:2907–2913

    PubMed  CAS  Google Scholar 

  • Blackmore PF, Bocckino SB, Waynick LE, Exton JH (1985) Role of guanine nucleotide-binding regulatory protein in the hydrolysis of hepatocyte phosphatidylinositol 4,5-biphosphate by calcium-mobilizing hormones and the control of cell calcium. J Biol Chem 260:14477–14483

    PubMed  CAS  Google Scholar 

  • Blair HC, Finch JL, Avioli R, Crouch EC, Slatopolsky E, Teitelbaum SL (1989) Micromolar aluminum levels reduce 3H-thymidine incorporation by cell line UMR 106-01. Kidney Int 35:1119–1125

    PubMed  CAS  Google Scholar 

  • Buys SS, Kushner JP (1989) Hematological effects of aluminum toxicity. In:Gitelman HJ (ed) Aluminum and health:a critical review. Dekker, New York, pp 235–256

    Google Scholar 

  • Chafi AH, Hauw J-J, Rancurel G, Berry J-P, Galle C (1991) Absence of aluminium in Alzheimer’s disease brain tissue:electron microprobe and ion microprobe studies. Neurosci Lett 123:61–64

    PubMed  CAS  Google Scholar 

  • Cochran M, Goddard G, Ludwigson N (1990) Aluminium absorption by rat duodenum:further evidence of energy-dependent uptake. Toxicol Lett 51:287–294

    PubMed  CAS  Google Scholar 

  • Cournot-Witmer G, Zingraff J, Plachott JJ, Escaig F, Lefevre R, Boumati P, Bourdeau A, Garabedian M, Galle P, Bourdon R, Drueke T, Balsan S (1981) Aluminum localization in bone from hemodialyzed patients:relationship to matrix mineralization. Kindey Int 20:375–385

    CAS  Google Scholar 

  • Crapper McLaughlin DR (1989) Aluminum neurotoxicity:criteria for assigning a role in Alzheimer’s disease. In:Lewis TE (ed) Environmental chemistry and toxicology of aluminum. Lewis, Chelsea, MI, pp 299–315

    Google Scholar 

  • De Voto E, Yokel RA (1994) Aluminum speciation and toxicokinetics. Environ Health Perspect (in press)

    Google Scholar 

  • Deleers M, Servais JP, Wulfert E (1986) Neurotoxic cations induce membrane rigidification and membrane fusion at micromolar concentrations. Biochim Biophys Acta 855:271–276

    PubMed  CAS  Google Scholar 

  • Domingo JL, Gomez M, Llobet JM, Corbella J (1991) Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 39:598–601

    PubMed  CAS  Google Scholar 

  • Driscoll CT Jr, Baker JP, Bisogni JJ Jr, Schofield CL (1980) Effect of aluminium speciation on fish in dilute acidified waters. Nature 284:161–164

    CAS  Google Scholar 

  • Edwardson JA, Candy JM, Ince PG, McArthu FK, Morris CM, Oakley AE, Taylor GA, Bjertness E (1992) Aluminum accumulation, ß-amyloid deposition and neurofibrillary changes in the central nervous system. In:Chadwick DJ, Whelan J (eds) Aluminum in biology and medicine. Wiley, New York, pp 165–185 (Ciba foundation symposium 169)

    Google Scholar 

  • Exley C, Birchall JD (1992) The cellular toxicity of aluminum. J Theor Biol 159:83–98

    PubMed  CAS  Google Scholar 

  • Farrer G, Altman P, Welch S, Wychrij O, Ghose B, Lejeune J, Cornett J, Prasher V, Blair J (1990) Defective gallium-transferrin binding in Alzheimer disease and Down syndrome:possible mechanism for accumulation of aluminum in brain. Lancet 335:747–750

    Google Scholar 

  • Feinroth M, Feinroth MV, Berlyne GM (1982) Aluminum absorption in the rat everted gut sac. Miner Electrolyte Metabol 8:29–35

    CAS  Google Scholar 

  • Fernandez Mendez MJ, Fell GS, Brock JH (1991) Aluminium uptake by intestinal cells; effect of iron status and precomplexation. Nephrol Dial Transplant 6:672–674

    Google Scholar 

  • Fleming JT, Joshi JG (1987) Ferritin:the role of aluminum in ferritin function. Neurobiol Aging 12:413–418

    Google Scholar 

  • Flendrig JA, Kruis H, Das HA (1976) Aluminium intoxication: the cause of dialysis dementia? Proc Eur Dial Transplant Assoc 13:355–361

    Google Scholar 

  • Froment DPH, Molitoris BA, Buddington B, Miller N, Alfrey AC (1989) Site and mechanism of enhanced gastrointestinal absorption of aluminium by citrate. Kidney Int 36:978–984

    PubMed  CAS  Google Scholar 

  • Fulton B, Jeffery EH (1990) Absorption and retention of aluminum from drinking water. Fund Appl Toxicol 14:788–796

    CAS  Google Scholar 

  • Fulton B, Jeffery EH (1994) Heme oxygenase induction:a possible factor in alumin um-associated anemia. Biol Trace Elem Res 40:9–19

    PubMed  CAS  Google Scholar 

  • Ganrot PO (1986) Metabolism and possible health effects of aluminum. Environ Health Perspect 65:363–441

    PubMed  CAS  Google Scholar 

  • Good PF, Pearl DP, Bierer LM, Schmeidler J (1992) Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer’s disease:a laser microprobe ( LAMMA) study. Ann Neurol 31:286–292

    PubMed  CAS  Google Scholar 

  • Goodman WG (1986) Experimental aluminum-induced bone disease:studies in vivo. Kidney Int 29:S32–S36

    CAS  Google Scholar 

  • Greger JL, Powers CF (1992) Assessment of exposure to parenteral and oral Al with and without citrate using a desferrioxamine test in rats. Toxicology 76:119–132

    PubMed  CAS  Google Scholar 

  • Gupta SK, Waters DH, Gwilt PR (1986) Absorption and disposition of aluminum in the rat. J Pharm Sci 75:586–589

    PubMed  CAS  Google Scholar 

  • Guy SP, Jones D, Mann DMA, Itzhaki RF (1991) Human neuroblastoma cells treated with aluminium express, an epitope associated with Alzheimer’s disease neurofibrillary tangles. Neurosci Lett 121:166–168

    PubMed  CAS  Google Scholar 

  • Hollosi M, Urge L, Perczel A, Kajtar J, Teplan I, Otvos L Jr, Fasman GD (1992) Metal ion-induced conformational changes of phosphorylated fragments of human neurofilament ( NF-M) protein. J Mol Biol 223:673–682

    PubMed  CAS  Google Scholar 

  • Huang Y-P, Bittar EE (1991) Protection by GTP from the effects of aluminum on the sodium efflux in barnacle muscle fibers. Biochim Biophys Acta 1062:255–263

    PubMed  CAS  Google Scholar 

  • Huber CT, Frieden E (1970) The inhibition of ferroxidase by trivalent and other metal ions. J Biol Chem 245:3979–3984

    PubMed  CAS  Google Scholar 

  • Ittel TH, Buddington B, Miller NL, Alfrey AC (1987) Enhanced gastrointestinal absorption of aluminum in uremic rats. Kidney Int 32:821–826

    PubMed  CAS  Google Scholar 

  • Johnson GVW, Jope RS (1987) Aluminum alters cyclic AMP and cyclic GMP levels but not presynaptic cholinergic markers in rat brain in vivo. Brain Res 403:1–6

    PubMed  CAS  Google Scholar 

  • Johnson GVW, Jope RS (1988) Phosphorylation of rat brain cytoskeletal proteins is increased after orally administered aluminum. Brain Res 456:95–103

    PubMed  CAS  Google Scholar 

  • Johnson GVW, Li X, Jope RS (1989) Aluminum increases agonist-stimulated cyclic AMP production in rat cerebral cortical slices. J Neurochem 53:258–263

    PubMed  CAS  Google Scholar 

  • Kappas A, Sassa S, Anderson KE (1983) The porphyrias. In:Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease, 5th edn. McGraw-Hill, New York, pp 1301–1384

    Google Scholar 

  • Kasai K, Hori MT, Goodman WG (1991) Transferrin enhances the antiproliferative effect of aluminium on osteoblast-like cells. Am J Physiol 260:E537–E543

    PubMed  CAS  Google Scholar 

  • Kawase T, Orikasa M, Suzuki A (1991) Aluminofluoride- and epidermal growth factor-stimulated DNA synthesis in MOB 3-4-F2 cells. Pharmacol Toxicol 69:330–337

    PubMed  CAS  Google Scholar 

  • Kerr DSN, Ward MK (1988) Aluminum intoxication:history of its clinical recognition and management. In:Siegel H (ed) Aluminum and its role in biology. Dekker, New York, pp 217–258

    Google Scholar 

  • Khalil-Manesh F, Agness C, Gonick HC (1989) Aluminum-binding protein in dialysis dementia. Nephron 52:323–328

    PubMed  CAS  Google Scholar 

  • Kirschbaum BB, Schoolwerth AC (1989) Acute aluminum toxicity associated with oral citrate and aluminum containing antacids. Am J Med Sci 297:9–11

    PubMed  CAS  Google Scholar 

  • Kostyniak PJ (1983) An electrothermal atomic absorption method for aluminum analysis in plasma:identification of sources of contamination in blood sampling procedures. J Anal Toxicol 7:20–23

    PubMed  CAS  Google Scholar 

  • Lai JCK, Lim L, Davison AM (1982) Effect of Cd2+, Mn2+, and Al3+ on rat brain synaptosomal uptake of noradrenaline and serotonin. J Inorg Biochem 17:215–225

    PubMed  CAS  Google Scholar 

  • Lau K, Farley JR, Freeman TK, Baylink DJ (1989) A proposed mechanism of the mitogenic action of fluoride on bone cells:inhibition of the activity of an osteoblastic acid phosphatase. Metabolism 38:858–868

    PubMed  CAS  Google Scholar 

  • Lau KHW, Yoo A, Wang SP (1991) Aluminum stimulates the proliferation and differentiation of osteoblasts in vitro by a mechanism that is different from fluoride. Mol Cell Biochem 105:93–105

    PubMed  CAS  Google Scholar 

  • Lau KHW, Utrapiromsuk S, Yoo A, Mohan S, Strong DD, Baylink DJ (1993) Mechanism of mitogenic action of aluminum ion on human bone cells:potential involvement of the insulin-like growth factor regulatory system. Arch Biochem Biophys 303:267–273

    PubMed  CAS  Google Scholar 

  • Leterrier JF, Langui D, Probst A, Ulrich J (1992) A molecular mechanism for the induction of neurofilament bundling by aluminum ions. J Neurochem 58:2060–2070

    PubMed  CAS  Google Scholar 

  • Lieberherr M, Grosse B, Cournot-Witmer G, Hermann-Erlee MPM, Balsan S (1987) Aluminum action on mouse bone cell metabolism and response to PTH and l,25(OH)2D3. Kidney Int 31:736–743

    PubMed  CAS  Google Scholar 

  • Maines MD, Kappas A (1976) Studies on the mechanism of induction of haem oxygenase by colbalt and other metal ions. Biochem J 154:125–131

    PubMed  CAS  Google Scholar 

  • Marquis J (1989) Neurotoxicity of aluminum. In:Lewis TE (ed) Environmental chemistry and toxicology of aluminum. Lewis, Chelsea, MI, pp 289–298

    Google Scholar 

  • Martin RB (1988) Bioinorganic chemistry of aluminum. In:Sigel H (ed) Metal ions in biological systems, vol 24. Dekker, New York, pp 1–58

    Google Scholar 

  • Martin RB (1992) Aluminum speciation in biology. In:Chadwick DJ, Whelan J (eds) Aluminum in biology and medicine. Wiley, New York, pp 5–25 (Ciba foundation symposium 169)

    Google Scholar 

  • May JC, Rains TC, Yu LJ, Etz NM (1992) Aluminum content of source plasma and sodium citrate anticoagulant. Vox Sang 62:65–69

    PubMed  CAS  Google Scholar 

  • McDonald LJ, Mamrack MD (1988) Aluminum affects phosphoinositide hydrolysis by phosphoinositidase C. Biochem Biophys Res Commun 155:203–208

    PubMed  CAS  Google Scholar 

  • McGonigle R, Parsons V (1985) Aluminium-induced anaemia in haemodialysis patients. Nephron 39:1–9

    PubMed  CAS  Google Scholar 

  • McGregor SJ, Naves ML, Oria R, Vass K, Brock JH (1990) Effect of aluminium on iron uptake and transferrin-receptor expression by human erythroleukaemia K562 cells. Biochem J 272:377–382

    PubMed  CAS  Google Scholar 

  • McGregor SJ, Brown D, Brock JH (1991) Transferrin-gallium binding in Alzheimer’s disease. Lancet 338:1394–1395

    Google Scholar 

  • Meredith PA, Moore MA, Goldberg A (1977) Effects of aluminium, lead and zinc on delta-aminolaevulinic acid dehydratase. Enzyme 22:22–27

    PubMed  CAS  Google Scholar 

  • Mertz LM, Horn VJ, Baum BJ, Ambudkar IS (1990) Calcium entry in rat parotid acini:activation by carbachol and aluminum fluroride. Am J Physiol 258:C654–C661

    PubMed  CAS  Google Scholar 

  • Mesters JR, deGraaf JM, Kraal B (1993) Divergent effects of fluoroaluminates on the peptide chain elongation factors EF-Tu and EF-G as members of the GTPase superfamily. FEBS 321:149–152

    CAS  Google Scholar 

  • Miller JL, Hubbard CM, Litman BJ, Macdonald TL (1989) Inhibition of transducin activation and guanosine triphosphatase activity by aluminum ion. J Biol Chem 264:243–250

    PubMed  CAS  Google Scholar 

  • Mladenovic J (1988) Aluminum inhibits erythropoiesis in vitro. J Clin Invest 81:1661–1665

    PubMed  CAS  Google Scholar 

  • Moreb J, Popovtzer MM, Friedlaenderm MM, Konijn AM, Hershko C (1983) Evaluation of iron status in patients on chronic dialysis:usefulness of bone marrow hemosiderin, serum ferritin, transferrin saturation, MCV and red cell protoporphyrin. Nephron 35:196–200

    PubMed  CAS  Google Scholar 

  • Moriyama Y, Rege A, Fisher JW (1975) Studies on an inhibitor of erythropoesis ii. Inhibitory effects of serum from uremic rabbits on heme synthesis in rabbit bone marrow culture. Proc Soc Exp Biol Med 148:94–97

    PubMed  CAS  Google Scholar 

  • Moshtaghie AA, Bazrafshan MR (1992) Comparative binding study of aluminum and chromium to human transferrin:effect of iron. Biol Trance Elem Res 32:39–45

    CAS  Google Scholar 

  • Moxon DR, Jeffery EH (1991) Aluminum distribution between plasma and erythrocytes varies with aluminum load and the use of anticoagulants. FASEB J 5:A876

    Google Scholar 

  • Muller L, Wilhelm M (1987) Effects of cadmium in rat hepatocytes:interaction with aluminum. Toxicology 44:193–201

    PubMed  CAS  Google Scholar 

  • Muma NA, Troncoso JC, Hoffman PN, Koo EH, Price DL (1988) Aluminium neurotoxicity:altered expression of cytsokeletal genes. Mol Brain Res 3:115–122

    CAS  Google Scholar 

  • Munoz-Garcia D, Pendlebury WW, Kessler JB, Pearl D (1986) An immunocytochemical comparison of cytoskeletal proteins in aluminum-induced and Alzheimer type neurofibrillary tangles. Acta Neuropathol (Berl) 70:243–248

    CAS  Google Scholar 

  • Nordal KP, Dahl E, Halse J, Aksnes L, Thomassen Y, Flatmark A (1992) Aluminum metabolism and bone histology after kidney transplantation:a one-year follow-up study. J Clin Endrocrinol Metab 74:1140–1145

    CAS  Google Scholar 

  • Partridge NA, Regnier FE, Reed WM, White JL, Hem SL (1992) Contribution of soluble aluminium species to absorption of aluminium from the rat gut in situ. Clin Sci 83:425–430

    PubMed  CAS  Google Scholar 

  • Pearl DP, Brody AR (1980) Alzheimer’s disease: x-ray spectrograph evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science 208:297–299

    Google Scholar 

  • Pei Y, Hercz G, Greenwood C, Sharrard D, Segre G, Manuel A, Saiphoo C, Fenton S (1992) Noninvasive prediction of aluminum bone disease in hemo- and peritoneal dialysis patients. Kidney Int 41:1374–1382

    PubMed  CAS  Google Scholar 

  • Pierides AM (1980) Haemodialysis osteodystrophy with osteomalacia as the main finding — relation to aluminium intoxication. Calcif Tissue Res 31:65–453

    Google Scholar 

  • Provan SD, Yokel RA (1988a) Influence of calcium on aluminum accumulation by the rat jejunal slice. Res Commun Chem Pathrol Pharmacol 59:79–92

    CAS  Google Scholar 

  • Provan SD, Yokel RA (1988b) Aluminium uptake by the in situ rat gut preparation. J Pharmacol Exp Ther 245:928–931

    PubMed  CAS  Google Scholar 

  • Quarles LD, Gitelman HJ, Drezner MK (1989) Aluminum-induced neo-osteogenesis:attenuation by parathyroid hormone deficiency. J Clin Invest 83:1644–1650

    PubMed  CAS  Google Scholar 

  • Quarles LD, Wenstrup RJ, Catillo SA, Drezner MK (1991) Aluminum-induced mitogenesis in MC3T3-E1 osteoblasts:potential mechanism underlying neo-osteogenesis. Endrocrinology 128:3144–3151

    CAS  Google Scholar 

  • Rahman H, Skillen AW, Channon SM, Ward MK, Kerr DNS (1985) Methods for studying the binding of aluminum by serum protein. Clin Chem 31:1969–1973

    PubMed  CAS  Google Scholar 

  • Rodrigues M, Felsenfeld AJ, Llach F (1990) Aluminum administration in the rat separately affects the osteoblast and bone mineralization. J Bone Miner Res 5:59–67

    Google Scholar 

  • Rosenlof K, Fyhrquist F, Tenhunen R (1990) Erythropoietin, aluminium, and anaemia in patients on haemodialysis. Lancet 335:247–249

    PubMed  CAS  Google Scholar 

  • Shils ME (1988) Magnesium in health and disease. Annu Rev Nutr 1988:429–460

    Google Scholar 

  • Short AIK, Winey RJ, Robson JS (1980) Reversible microcytic hypochromic anemia in dialysis patients due to aluminium intoxication. Proc EDTA 17:226–233

    CAS  Google Scholar 

  • Singer HS, Serles CD, Hahn IH, March JL, Troncoso JC (1990) The effect of aluminum on markers for synaptic neurotransmission, cyclic AMP, and neuro-filaments in a neuroblastoma x glioma hybridoma (NG108-15). Brain Res 528:73–79

    PubMed  CAS  Google Scholar 

  • Sprague SM, Bushinsky DA (1990) Mechanism of aluminum-induced calcium efflux from cultured neonatal mouse calvariae. Am J Physiol 258:F583–F588

    PubMed  CAS  Google Scholar 

  • Sternweis PC, Gilman AG (1982) Aluminum:a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Aci USA 1982 79:4888–4891

    Google Scholar 

  • Stevens BJ, Willis GL, Humphrey TJ, Atkins RC (1987) Combined toxicity of aluminum and fluoride in the rat:possible implications in hemodialysis. Tr Elem Med 4:61–66

    CAS  Google Scholar 

  • Swartz RD, Dombrouski J, Burnatowska-Hledin M, Mayor GH (1985) Microcytic anemia:a marker for the diagnosis of aluminum toxicity. Proc EDTA 22:101–105

    Google Scholar 

  • Tielmans C, Collart F, Wens R, Smeyers-Verbeeke J, Van Hooff I, Dratwa M, Verbeelen D (1985) Improvement of anemia with deferroxiamine in hemodialysis in patients with aluminum-induced bone disease. Clin Nephrol 24:237–241

    Google Scholar 

  • Touam M, Martinex F, Lacour B, Bourdon R, Zingraff J, DiGuilio S, Drueke T (1983) Aluminum-induced, reversible microcytic anemia in chronic renal failure:clinical and experimental studies. Clin Nephrol 19:295–298

    PubMed  CAS  Google Scholar 

  • Trapp GA (1983) Plasma aluminium is bound to transferrin. Life Sci 33:311–316

    PubMed  CAS  Google Scholar 

  • Umeda M, Tsurusaki K, Kamikawa S, Izumi N, Tasumoto R, Kishimoto T, Maekawa M (1990) Red blood cell aluminum in patients with renal failure and effect of desferoxamine infusion. Blood Purif 8:295–300

    PubMed  CAS  Google Scholar 

  • Van der Voet GB (1992a) Intestinal absorption of aluminum — relation to neurotoxicity. In: Isaacson RL, Jensen KF (eds) The vulnerable brain and environmental risks, vol 12: toxins in food. Plenum, New York, pp 35–47

    Google Scholar 

  • Van der Voet GB (1992b) Intestinal absorption of aluminum. In:Chadwick DJ, Whelan J (eds) Aluminum in biology and medicine. Wiley, New York, pp 117–122 (Ciba foundation symposium 169 )

    Google Scholar 

  • Van der Voet GB, De Wolff FA (1987) The effect of di- and trivalent iron on the intestinal absorption of aluminium in rats. Toxicol Appl Pharmacol 90:190–197

    PubMed  Google Scholar 

  • Vasilakakis DM, O’Haese PC, Lamberts LV, Lemoniatou E, Dignensis PN, De Broe ME (1992) Removal of aluminoxamine and ferrioxamine by charcoal hemoperfusion and hemodialysis. Kidney Int 41:1400–1407

    PubMed  CAS  Google Scholar 

  • Ward JH, Jordan I, Kushner JP, Kaplan J (1984) Heme regulation of HeLa cell transferrin receptor number. J Biol Chem 259:13235–13240

    PubMed  CAS  Google Scholar 

  • Weberg R, Berstad A (1986) Gastrointestinal absorption of A1 from single doses of aluminum-containing antacids in man. Eur J Clin Invest 16:428–432

    PubMed  CAS  Google Scholar 

  • Yamamoto H, Saitoh Y, Yasugawa S, Miyamoto E (1990) Dephosphorylation of tau factor by protein phosphatase 2A synaptosomal cytosol fractions and inhibition by aluminum. J Neurochem 55:683–690

    PubMed  CAS  Google Scholar 

  • Yatani A, Brown AM (1991) Mechanism of fluoride activation of G protein-gated muscarinic atrial K+ channels. J Biol Chem 266:22872–222877

    PubMed  CAS  Google Scholar 

  • Yates CM, Simpson J, Russel D, Gordon A (1980) Cholinergic enzymes in neurofibrillary degeneration produced by aluminium. Brain Res 197:269–274

    PubMed  CAS  Google Scholar 

  • Yokel RA, McNamara PJ (1985) Aluminum bioavailability and disposition in adult and immature rabbits. Toxicol Appl Pharmacol 77:344–352

    PubMed  CAS  Google Scholar 

  • Zaman K, Mukhtar M, Siddique H, Miszta H (1992) The effect of aluminum on the stromal cells in vitro on bone marrow in rats. Toxicol Ind Health 8:103–109

    PubMed  CAS  Google Scholar 

  • Zaman K, Zaman W, Dabrowski Z, Miszta H (1993) Inhibition of delta amino-evulinic acid dehydratase activity by aluminum. Comp Biochem Physiol 104C:269–273

    CAS  Google Scholar 

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  1. Department of Pathology, University of Western Ontario, N6A 5C1, Ontario, Canada

    Robert A. Goyer M.D. (Professor Emeritus) & M. George Cherian Ph.D. (Professor) (Professor Emeritus) &  (Professor)

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Jeffery, E.H. (1995). Biochemical Mechanisms of Aluminum Toxicity. In: Goyer, R.A., Cherian, M.G. (eds) Toxicology of Metals. Handbook of Experimental Pharmacology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79162-8_7

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