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Clusterin: A Role in Cell Survival in the Face of Apoptosis?

  • Chapter
Apoptosis

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 16))

Abstract

Clusterin is a multifunctional glycoprotein complex found in virtually all body fluids and on the surface of cells lining body cavities. Demonstrated and proposed functions include the transport of lipoproteins, the inhibition of complementmediated cell lysis and the modulation of cell-cell interactions. On the basis of its elevated expression in apoptotic tissues, it was originally proposed that the protein might be casually involved in apoptosis. Here, we discuss the recent data that, in contrast to the earlier notion, suggest that clusterin expression is not enhanced, but rather is down-regulated in the cells undergoing apoptosis and that its expression in the apoptotic tissue is restricted to the vital neighboring cells. These results led to the proposal that rather than being a cell death gene, clusterin is a cell survival gene, exerting a protective function on the surving bystander cells.

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Authors and Affiliations

  1. Institut für Biochemie, Johannes Gutenberg-Universität, Becherweg 30, 55099, Mainz, Germany

    C. Koch-Brandt

  2. Max Planck Institut für Hirnforschung, Abteilung Neurochemie, Deutschordenstr. 46, 60528, Frankfurt/Main, Germany

    C. Morgans

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  1. C. Koch-Brandt
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Editors and Affiliations

  1. Dept. of Biophysics, National Cancer Center Research Institute, Tsukiji 5-Chome, Chuoko, Tokyo, Japan

    Y. Kuchino

  2. Abteilung für Angewandte Molekularbiologie, Universität Mainz, Institut für Physiologische Chemie, Duesbergweg 6, 55099, Mainz, Germany

    W. E. G. Müller

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Koch-Brandt, C., Morgans, C. (1996). Clusterin: A Role in Cell Survival in the Face of Apoptosis?. In: Kuchino, Y., Müller, W.E.G. (eds) Apoptosis. Progress in Molecular and Subcellular Biology, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79850-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-79850-4_8

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