Skip to main content
SpringerLink
Log in

Toxizität von Lokalanästhetika

  • Conference paper
Juni 1996, Nürnberg

Part of the book series: Refresher Course Aktuelles Wissen für Anästhesisten ((REFRESHER COUR,volume 22))

  • 24 Accesses

Zusammenfassung

Die sachgemäße Durchführung von Regionalanästhesien stellt für viele operative Eingriffe ein sicheres Betäubungsverfahren dar, welches als alleinige Methode oder in Kombination mit einer Allgemeinanästhesie genutzt wird. Neben einem sicheren Umgang mit den einzelnen Techniken der Regionalanästhesie ist es insbesondere erforderlich, Wirkeigenschaften und Komplikationsmöglichkeiten der unterschiedlichen Lokalanästhetika zu kennen, um entsprechende Gefahren vom Patienten abwenden zu können.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Albright GA (1979) Cardiac arrest following regional anesthesia with etidocain or bupivacaine. Anesthesiology 51: 285–287

    Article  PubMed  CAS  Google Scholar 

  2. Aldrete JA (1984) Reverse arterial blood flow: a mechanism for neurotoxicity from local anesthetics. In: Wüst HJ, Stanton-Hicks MDA, Zindler M (Hrsg) Neue Aspekte der Regionalanästhesie und Intensivmedizin 158. Springer, Heidelberg Berlin New York, S 62–67

    Google Scholar 

  3. Bachmann-Mennenga B, Biscoping J, Sinning E, Hempelmann G (1990) Protein binding of prilocaine in human plasma: influence of concentration, pH_and temperature. Acta Anaesthesiol Scand 34: 311–314

    Article  Google Scholar 

  4. Bader AM, Datta S, Flanagan H, Covino BG (1989) Comparison of bupivacaine-and ropivacaine-induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg 68: 724–727

    Article  PubMed  CAS  Google Scholar 

  5. Biscoping J, Kling D, von Bormann B, Hehrlein F, Hempelmann G (1985) Vergleichende Untersuchungen zur Dosisanpassung der intraoperativen Lidocain-Therapie bei herzinsuffizienten Patienten. Anästh Intensivther Notfallmed 20: 136–138

    Article  PubMed  CAS  Google Scholar 

  6. Bräu M, Vogel W, Hempelmann G (1992) Wie blockieren Lokalanästhetika den Schmerz ? Spiegel der Forschung. Wissenschaftsmagazin der Universität Gießen 1: 33–36

    Google Scholar 

  7. Clarkson CW, Hondeghem LM (1985) Evidence for a specific receptor site for lidocaine, quinidine, and bupivacaine associated with cardiac sodium channels in guinea pig ventricular myocardium. Circ Res 56: 496–506

    PubMed  CAS  Google Scholar 

  8. Clarkson CW, Hondeghem LM (1985) Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 62: 396–405

    Article  PubMed  CAS  Google Scholar 

  9. Courtney KR, Kendig JJ (1988) Bupivacaine is an effective potassium channel blocker in heart. Biochem Biophys Acta 939: 163–166

    Article  PubMed  CAS  Google Scholar 

  10. Coyle DE, Speralakis N (1987) Bupivacaine and lidocaine blockade of calcium-mediated slow action potentials in guinea-pig ventricular muscle. J Pharmacol Exp Ther 242: 1001–1005

    PubMed  CAS  Google Scholar 

  11. Drysdale DB (1984) Experimental subdural retrobulbar injection of anesthetic. Ann Ophthalmol 16: 716–718

    PubMed  CAS  Google Scholar 

  12. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamptechniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391: 85–100

    Article  PubMed  CAS  Google Scholar 

  13. Jonas P, Bräu M, Hermsteiner M, Vogel W (1989) Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels. Proc Natl Acad Sci USA 86: 7238–7242

    Article  PubMed  CAS  Google Scholar 

  14. Koh DS, Jonas P, Bräu M, Vogel WA (1992) TEA-insensitive flickering potassium channel active around the resting potential in myelinated nerve. J Membrane Bio1130: 149–162

    Google Scholar 

  15. Lehmann KA (1986) Pharmakokinetische und dynamische Aspekte bei der repetetiven Anwendung von Lokalanästhetika. In: Hempelmann G, Biscoping J (Hrsg) Regionalanästhesiologische Aspekte 1, Kontinuierliche Verfahren der Regionalanästhesie. Astra Chemicals

    Google Scholar 

  16. Mazoit JX, Orhant EE, Boico O, Kantelip JP, Samii K (1993) Myocardial uptake of bupivacaine: I. Pharmacokinetics and pharmacodynamics of lidocaine and bupivacaine in the isolated perfused rabbit heart. Anesth Analg 77: 469–476

    Google Scholar 

  17. Möller RA, Covino BG (1988) Cardiac electrophysiologic effects of lidocaine and bupivacaine. Anesth Analg 67: 107–114

    Article  PubMed  Google Scholar 

  18. Reiz S, Häggmark S, Johansson J, Nath S (1989) Cardiotoxicity of ropivacaine–a new amide local anaesthetic. Acta Anaesthesiol Scand 33: 93–98

    Article  PubMed  CAS  Google Scholar 

  19. Rutten AJ, Nancarrow C, Mather LE (1989) Hemodynamic and central nervous system effects of lidocaine, bupivacaine and ropivacaine in sheep. Anesth Analg 69: 291–299

    Article  PubMed  CAS  Google Scholar 

  20. Stienstra R, Jonker TA, Bourdrez P, Kuijpers JC, van Kleef JW, Lundberg U (1995) Ropivacaine 0.25% versus bupivacaine 0.25% for continuous epidural analgesia in labor: a double-blind comparison. Anesth Analg 80: 285–289

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. B. Bachmann-Mennenga
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Bachmann-Mennenga, B. (1996). Toxizität von Lokalanästhetika. In: Juni 1996, Nürnberg. Refresher Course Aktuelles Wissen für Anästhesisten, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80155-6_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80155-6_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60951-3

  • Online ISBN: 978-3-642-80155-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation