Abstract
The antitumor effect of BM 12,531, 2-[2-cyanaziridinyl-(1)]-2[carbamoylaziridi-nyl-(1)]-propane (Prop. INN azimexon), on L1210 leukemia in mice is described. The immunostimulating compound BM 12,531 can also reduce the acute toxicity of X-irradiation in mice. The most effective doses in these experiments are 1 or 5 mg/kg twice a week, whereas 50 and 500 mg/kg twice a week decrease the therapeutic effect. The mortalitiy of Candida-infected and irradiated mice is also reduced by oral administration of BM 12,531. BM 12,531 has synergistic effects with subtherapeutic doses of chloramphenicol in an experimental E. coli infection in mice.
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References
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© 1980 Springer-Verlag Berlin Heidelberg
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Bicker, U. (1980). Therapeutic Effects of BM 12,531 (Prop. INN Azimexon). In: Mathé, G., Muggia, F.M. (eds) Cancer Chemo- and Immunopharmacology. Recent Results in Cancer Research, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81491-4_23
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DOI: https://doi.org/10.1007/978-3-642-81491-4_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81493-8
Online ISBN: 978-3-642-81491-4
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