Skip to main content

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 82))

Abstract

The marked rise in the incidence of respiratory carcinomas, particularly bronchogenic ones [7, 43], and the disappointing results of their treatment have led to emphasis on the importance of prevention as well as early detection. Accordingly, it is interesting to consider the pathogenesis of respiratory carcinomas and especially its relationship to inhaled substances. This contribution, from the point of view of pulmonary medicine, will first consider the environmental factors and second the specificity of the respiratory system with respect to environmental carcinogens in comparison with the other sites of tumors.

The author is indebted to Dr. R. Masse for his contributions and redaction of this paper

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ames BN, Lee FD, Durston WE (1973) An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc Natl Acad Sci USA 70: 782–786

    Article  PubMed  CAS  Google Scholar 

  2. Barton RT, Hogetveix AC (1980) Nickel-related cancers of the respiratory tract. Cancer 45: 3061–3064

    Article  PubMed  CAS  Google Scholar 

  3. Berenblum I (1978) Established principles and unresolved problems in carcinogenesis. J Natl Cancer Inst 60: 723–726

    PubMed  CAS  Google Scholar 

  4. Berry G, Newhouse ML, Turok M (1972) Combined effect of asbestos exposure and smoking on mortality from lung cancer in factory workers. Lancet 2: 476–479

    Article  PubMed  CAS  Google Scholar 

  5. Bidstrup PL, Case RA (1956) Carcinoma of the lung in workmen in the bichromates producing industry in Great Britain. Br J Ind Med 13: 260–264

    PubMed  CAS  Google Scholar 

  6. Bucciarelli E, Ribacchi R (1972) C. type particles in primary and transplanted lung tumors induced in Balb/c mice by hydrazine sulfate: electron microscopic and immunodiffusion studies. J Natl Cancer Inst 49: 673–684

    PubMed  CAS  Google Scholar 

  7. Chahinian AP, Chretien J (1976) Present incidence of lung cancer. Epidemiologic data and etiologic factors. In: Israel L, Chahinian AP (eds) Lung Cancer natural history, prognosis, and therapy. Academic Press, New York San Francisco London, pp 1–22

    Google Scholar 

  8. Chretien J (1979) Rôle du tabac dans les perturbations des défenses immunitaires pulmonaires. Rappel introductif. Nouv Presse Med 8: 2131–2134

    PubMed  CAS  Google Scholar 

  9. Chretien J (1980) Pénétration et devenir des aérocontaminants inhalés par le poumon. In: Charpin J (ed) Allergologie. Flammarion Medecine, Paris, pp 308–323

    Google Scholar 

  10. Chretien J, Masse R (1976) La cancerogenèse broncho-pulmonaire. Revue des faits expérimentaux. Rev Fr Mal Respir 4: 23–45

    Google Scholar 

  11. Chretien J, Thieblemont M (1979) Un mécanisme intermédiaire dans la carcinogenèse pulmonaire. Nouv Presse Med 3: 1347–1350

    Google Scholar 

  12. Chretien J, Hirsch A, Harf A, Thieblemont M (1972) Le rôle du tabac en pathologie respiratoire. Rev Tuberc Pneumol 36: 243–280

    CAS  Google Scholar 

  13. Chretien J, Hirsch A, Thieblemont M (1973) Pathologie du tabac. L’expérimentation animale dans le monde. Objectifs et Méthodologie. Masson, Paris

    Google Scholar 

  14. Chretien J, Thieblemont M, Masse R, Chameaud J, Perraud R, Lebas F (1975) Action de la fumée de tabac sur le macrophage alvéolaire. Nouv Presse Med 32: 2327–2331

    Google Scholar 

  15. Chretien J, Masse R, Arnoux B, Stanislas G, Arnoux A, Queval P (1977) Agents carcinogènes et mécanismes d’action. Rev Fr Mal Respir [Suppl] 5: 19–23

    Google Scholar 

  16. Chretien J, Huchon G, Marsac J (to be published) Defence mechanisms of the respiratory tract. In: Freour P, Holland W (eds) Chronic non-specific respiratory disease. Henry Kimpton, London

    Google Scholar 

  17. Clayton DB, Shubik P (1976) The carcinogenic action of drugs. Cancer Detect Prey 1: 43–77

    Google Scholar 

  18. Doll R, Morgan G, Speizer FE (1970) Cancers of the lung and nasal sinuses in nickel workers. Br J Cancer 24: 623–632

    Article  PubMed  CAS  Google Scholar 

  19. Eriksson S, Moestrup T, Hagerstrand I (1975) Liver, lung and malignant disease in heterozygous (Pi MZ) αl-antitrypsin deficiency. Acta Med Scand 198: 243–247

    Article  PubMed  CAS  Google Scholar 

  20. Gabelman N, Waxman S, Smith W, Douglas SD (1975) Appearance of C-type virus-like particles after cocultivation of a human tumor-cell line with rat ( X.C.) cells. Int J Cancer 16: 355

    Article  Google Scholar 

  21. Green GM, Jakab GJ, Low RB, Davis GS (1978) Defense mechanisms of the respiratory membrane. In: Murray JJ (ed) Lung disease. State of the art. American Lung Association, New York

    Google Scholar 

  22. Harris CC (1974) Cause and prevention of lung cancer. Semin Oncol 1: 163–166

    PubMed  CAS  Google Scholar 

  23. Hill AB, Faning EL (1948) Studies in the incidence of cancer in a factory handling inorganic compounds of arsenic. I. Mortality experience in the factory. Br J Ind Med 5: 1–15

    PubMed  CAS  Google Scholar 

  24. Hoffmann D, Wynder EL (1976) Smoking and occupational cancers. Prey Med 5: 245–261

    Article  CAS  Google Scholar 

  25. James AC, Birdrall A, Greenhalg JR (1980) A model for dosimetry of the respiratory tract for inhaled radon daughters. EULEP Newsletter 21: 20–21

    Google Scholar 

  26. Kellerman G, Shaw CR, Luyten-Kellerman M (1973) Aryl-hydrocarbon-hydroxylase inducibility and bronchogenic carcinoma. N Engl J Med 289: 934

    Article  Google Scholar 

  27. Lee AM, Fraumeni JF (1969) Arsenic and respiratory cancer in man: an occupational study. J Natl Cancer Inst 42: 1045–1052

    PubMed  CAS  Google Scholar 

  28. Lupulescu AP, Brinkman GL (1971) Cytoplasmic inclusion bodies in pulmonary tumors. An electron microscopic study. Amer J Clin Pathol 56: 553

    CAS  Google Scholar 

  29. MacCann J, Choi E, Yamasaki E, Ames BN (1975) Detection of carcinogens as mutagens in the Salmonella/microsome test. Assay of 300 chemicals. Proc Natl Acad Sci USA 72: 5135–5139

    Article  Google Scholar 

  30. Mancuso IF (1970) Relation of duration of employment and prior respiratory illness to respiratory cancer among beryllium workers. Environ Res 3: 251

    Article  PubMed  CAS  Google Scholar 

  31. Masse R, Arnoux B (1978) Mécanismes de la cancérisation bronchique. Rev Prat 28: 4679–4685

    PubMed  CAS  Google Scholar 

  32. Masse R, Fritsch P, Ducousso R, Lafuma J, Chretien J (1973) Rétention de particules dans les cellules bronchiques, relations possibles avec les carcinogènes inhalés. CR Acad Sci [D] (Paris) 276: 2923–2925

    CAS  Google Scholar 

  33. McDonald AD (1976) Etudes épidémiologiques sur les maladies dues à l’amiante au Canada. Rev Fr Mal Respir [Suppl] 4: 25–38

    Google Scholar 

  34. Miller JA (1970) Carcinogenesis by chemicals: an overview. G.H.A. Clowes memorial lecture. Cancer Res 30: 559–576

    PubMed  CAS  Google Scholar 

  35. Morgan JM (1972) Hepatic copper, manganese and chromium content in bronchogenic carcinoma. Cancer 29: 710–713

    Article  PubMed  CAS  Google Scholar 

  36. Nash D, McLarty JW, Forston NG (1980) Pretreatment, prediagnosis immunoglobulins and alpha-1-antitrypsine levels in patients with bronchial carcinoma. J Natl Cancer Inst 64: 721–724

    PubMed  CAS  Google Scholar 

  37. NATO Advanced Research Institute. In vitro toxicity testing of environmental agents: current and future possibilities. (Abstr.) Monaco meeting, Sept 22–28, 1979

    Google Scholar 

  38. Paigen B, Gurtoo HL, Minowada J et al. (1977) Questionable relation of aryl-hydrocarbon-hydroxylase to lung cancer risk. N Engl J Med 297: 346–350

    Article  PubMed  CAS  Google Scholar 

  39. Penaud R, Chameaud J, Lafuma J, Masse R, Chretien J (1972) Cancer broncho-pulmonaire experimental du rat par inhalation de radon. Comparaison avec les aspects histologiques des cancers humains J Fr Med Chir Thorac 26: 25–41

    Google Scholar 

  40. Saccomanno G, Ardher VE, Auerbach O, Kuschner M, Saunders RP, Klein MG (1971) Histologic types of lung cancers among uranium miners. Caner 27: 515–523

    Article  CAS  Google Scholar 

  41. Selikoff IJ (1976) Asbestos disease in the United States 1918–1975. Rev Fr Mal Respir [Suppl] 4: 7–24

    Google Scholar 

  42. Selikoff IJ, Hammond EC, Churg J (1968) Asbestos exposure, smoking and neoplasia. J Am Med Assoc 204: 106–112

    Article  CAS  Google Scholar 

  43. Sterling TD, Pollack SV (1972) The incidence of lung cancer in the U.S. since 1955 in relation to the etiology of the disease. Am J Public Health 62: 152–158

    Article  PubMed  CAS  Google Scholar 

  44. Sunderman FW (1976) A review of the carcinogenicities of nickel, chromium and arsenic compounds in man and animal. Prey Med 5: 279–294

    Article  CAS  Google Scholar 

  45. Weibel ER (1963) Morphometry of the human lung. NY Acad Press, New York

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Chrétien, J. (1982). Inhalation Carcinogenesis: An Overview. In: Band, P.R. (eds) Early Detection and Localization of Lung Tumors in High Risk Groups. Recent Results in Cancer Research, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81768-7_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-81768-7_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81770-0

  • Online ISBN: 978-3-642-81768-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics