Abstract
The marked rise in the incidence of respiratory carcinomas, particularly bronchogenic ones [7, 43], and the disappointing results of their treatment have led to emphasis on the importance of prevention as well as early detection. Accordingly, it is interesting to consider the pathogenesis of respiratory carcinomas and especially its relationship to inhaled substances. This contribution, from the point of view of pulmonary medicine, will first consider the environmental factors and second the specificity of the respiratory system with respect to environmental carcinogens in comparison with the other sites of tumors.
The author is indebted to Dr. R. Masse for his contributions and redaction of this paper
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References
Ames BN, Lee FD, Durston WE (1973) An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc Natl Acad Sci USA 70: 782–786
Barton RT, Hogetveix AC (1980) Nickel-related cancers of the respiratory tract. Cancer 45: 3061–3064
Berenblum I (1978) Established principles and unresolved problems in carcinogenesis. J Natl Cancer Inst 60: 723–726
Berry G, Newhouse ML, Turok M (1972) Combined effect of asbestos exposure and smoking on mortality from lung cancer in factory workers. Lancet 2: 476–479
Bidstrup PL, Case RA (1956) Carcinoma of the lung in workmen in the bichromates producing industry in Great Britain. Br J Ind Med 13: 260–264
Bucciarelli E, Ribacchi R (1972) C. type particles in primary and transplanted lung tumors induced in Balb/c mice by hydrazine sulfate: electron microscopic and immunodiffusion studies. J Natl Cancer Inst 49: 673–684
Chahinian AP, Chretien J (1976) Present incidence of lung cancer. Epidemiologic data and etiologic factors. In: Israel L, Chahinian AP (eds) Lung Cancer natural history, prognosis, and therapy. Academic Press, New York San Francisco London, pp 1–22
Chretien J (1979) Rôle du tabac dans les perturbations des défenses immunitaires pulmonaires. Rappel introductif. Nouv Presse Med 8: 2131–2134
Chretien J (1980) Pénétration et devenir des aérocontaminants inhalés par le poumon. In: Charpin J (ed) Allergologie. Flammarion Medecine, Paris, pp 308–323
Chretien J, Masse R (1976) La cancerogenèse broncho-pulmonaire. Revue des faits expérimentaux. Rev Fr Mal Respir 4: 23–45
Chretien J, Thieblemont M (1979) Un mécanisme intermédiaire dans la carcinogenèse pulmonaire. Nouv Presse Med 3: 1347–1350
Chretien J, Hirsch A, Harf A, Thieblemont M (1972) Le rôle du tabac en pathologie respiratoire. Rev Tuberc Pneumol 36: 243–280
Chretien J, Hirsch A, Thieblemont M (1973) Pathologie du tabac. L’expérimentation animale dans le monde. Objectifs et Méthodologie. Masson, Paris
Chretien J, Thieblemont M, Masse R, Chameaud J, Perraud R, Lebas F (1975) Action de la fumée de tabac sur le macrophage alvéolaire. Nouv Presse Med 32: 2327–2331
Chretien J, Masse R, Arnoux B, Stanislas G, Arnoux A, Queval P (1977) Agents carcinogènes et mécanismes d’action. Rev Fr Mal Respir [Suppl] 5: 19–23
Chretien J, Huchon G, Marsac J (to be published) Defence mechanisms of the respiratory tract. In: Freour P, Holland W (eds) Chronic non-specific respiratory disease. Henry Kimpton, London
Clayton DB, Shubik P (1976) The carcinogenic action of drugs. Cancer Detect Prey 1: 43–77
Doll R, Morgan G, Speizer FE (1970) Cancers of the lung and nasal sinuses in nickel workers. Br J Cancer 24: 623–632
Eriksson S, Moestrup T, Hagerstrand I (1975) Liver, lung and malignant disease in heterozygous (Pi MZ) αl-antitrypsin deficiency. Acta Med Scand 198: 243–247
Gabelman N, Waxman S, Smith W, Douglas SD (1975) Appearance of C-type virus-like particles after cocultivation of a human tumor-cell line with rat ( X.C.) cells. Int J Cancer 16: 355
Green GM, Jakab GJ, Low RB, Davis GS (1978) Defense mechanisms of the respiratory membrane. In: Murray JJ (ed) Lung disease. State of the art. American Lung Association, New York
Harris CC (1974) Cause and prevention of lung cancer. Semin Oncol 1: 163–166
Hill AB, Faning EL (1948) Studies in the incidence of cancer in a factory handling inorganic compounds of arsenic. I. Mortality experience in the factory. Br J Ind Med 5: 1–15
Hoffmann D, Wynder EL (1976) Smoking and occupational cancers. Prey Med 5: 245–261
James AC, Birdrall A, Greenhalg JR (1980) A model for dosimetry of the respiratory tract for inhaled radon daughters. EULEP Newsletter 21: 20–21
Kellerman G, Shaw CR, Luyten-Kellerman M (1973) Aryl-hydrocarbon-hydroxylase inducibility and bronchogenic carcinoma. N Engl J Med 289: 934
Lee AM, Fraumeni JF (1969) Arsenic and respiratory cancer in man: an occupational study. J Natl Cancer Inst 42: 1045–1052
Lupulescu AP, Brinkman GL (1971) Cytoplasmic inclusion bodies in pulmonary tumors. An electron microscopic study. Amer J Clin Pathol 56: 553
MacCann J, Choi E, Yamasaki E, Ames BN (1975) Detection of carcinogens as mutagens in the Salmonella/microsome test. Assay of 300 chemicals. Proc Natl Acad Sci USA 72: 5135–5139
Mancuso IF (1970) Relation of duration of employment and prior respiratory illness to respiratory cancer among beryllium workers. Environ Res 3: 251
Masse R, Arnoux B (1978) Mécanismes de la cancérisation bronchique. Rev Prat 28: 4679–4685
Masse R, Fritsch P, Ducousso R, Lafuma J, Chretien J (1973) Rétention de particules dans les cellules bronchiques, relations possibles avec les carcinogènes inhalés. CR Acad Sci [D] (Paris) 276: 2923–2925
McDonald AD (1976) Etudes épidémiologiques sur les maladies dues à l’amiante au Canada. Rev Fr Mal Respir [Suppl] 4: 25–38
Miller JA (1970) Carcinogenesis by chemicals: an overview. G.H.A. Clowes memorial lecture. Cancer Res 30: 559–576
Morgan JM (1972) Hepatic copper, manganese and chromium content in bronchogenic carcinoma. Cancer 29: 710–713
Nash D, McLarty JW, Forston NG (1980) Pretreatment, prediagnosis immunoglobulins and alpha-1-antitrypsine levels in patients with bronchial carcinoma. J Natl Cancer Inst 64: 721–724
NATO Advanced Research Institute. In vitro toxicity testing of environmental agents: current and future possibilities. (Abstr.) Monaco meeting, Sept 22–28, 1979
Paigen B, Gurtoo HL, Minowada J et al. (1977) Questionable relation of aryl-hydrocarbon-hydroxylase to lung cancer risk. N Engl J Med 297: 346–350
Penaud R, Chameaud J, Lafuma J, Masse R, Chretien J (1972) Cancer broncho-pulmonaire experimental du rat par inhalation de radon. Comparaison avec les aspects histologiques des cancers humains J Fr Med Chir Thorac 26: 25–41
Saccomanno G, Ardher VE, Auerbach O, Kuschner M, Saunders RP, Klein MG (1971) Histologic types of lung cancers among uranium miners. Caner 27: 515–523
Selikoff IJ (1976) Asbestos disease in the United States 1918–1975. Rev Fr Mal Respir [Suppl] 4: 7–24
Selikoff IJ, Hammond EC, Churg J (1968) Asbestos exposure, smoking and neoplasia. J Am Med Assoc 204: 106–112
Sterling TD, Pollack SV (1972) The incidence of lung cancer in the U.S. since 1955 in relation to the etiology of the disease. Am J Public Health 62: 152–158
Sunderman FW (1976) A review of the carcinogenicities of nickel, chromium and arsenic compounds in man and animal. Prey Med 5: 279–294
Weibel ER (1963) Morphometry of the human lung. NY Acad Press, New York
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Chrétien, J. (1982). Inhalation Carcinogenesis: An Overview. In: Band, P.R. (eds) Early Detection and Localization of Lung Tumors in High Risk Groups. Recent Results in Cancer Research, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81768-7_1
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