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Pharmacokinetic Modeling and the Teratologist

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Teratogenesis and Reproductive Toxicology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 65))

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Abstract

Pharmacokinetics has proven to be an exceptional tool in pharmaceutical and pharmacologic research. Its development has enhanced the capabilities of providing optimum dosing schedules and formulations for delivery of ethical drugs by relating blood levels of a particular drug to its therapeutic efficacy. Likewise, perturbations in the pharmacokinetic parameters of a compound produced by interactions with a second chemical or with fiver or kidney insufficiency, for example, have provided a more logical basis for the study of drug-drug or drug-chemical interactions, as well as effects of disease states in clinical pharmacology.

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Authors
  1. J. F. Young
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Editors and Affiliations

  1. Jefferson Medical College, 1020 Locust Street, Philadelphia, PA, 19107, USA

    E. Marshall Johnson Ph.D. (Professor and Chairman of Department of Anatomy, Director of Daniel Baugh Institute) (Professor and Chairman of Department of Anatomy, Director of Daniel Baugh Institute)

  2. Department of Anatomy, Daniel Baugh Institute, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 19107, USA

    Devendra M. Kochhar Ph.D.

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© 1983 Springer-Verlag Berlin Heidelberg

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Young, J.F. (1983). Pharmacokinetic Modeling and the Teratologist. In: Johnson, E.M., Kochhar, D.M. (eds) Teratogenesis and Reproductive Toxicology. Handbook of Experimental Pharmacology, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81919-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-81919-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81921-6

  • Online ISBN: 978-3-642-81919-3

  • eBook Packages: Springer Book Archive

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