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Part of the book series: Verhandlungen der Deutschen Gesellschaft für Neurologie ((VDGNEUROLOGIE,volume 4))

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Abstract

The 1980s will probably remain the decade of a world-wide concern with therapeutic trials in multiple sclerosis (MS). Until recent years, efforts mainly concerned alleviation of clinical symptoms and complications resulting from the disease. In fact, important progress has been made in this field, and it is obvious that the life expectancy of MS patients has been markedly extended since the second World War. More recently, a better understanding of the immune mechanisms underlying the progression of the disease, and encouraging preliminary clinical results have rekindled interest in therapies capable of influencing the evolution of the disease.

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References

  1. Barnes MP, Bates D, Cartlidge NEF, French JM, Shaw DA (1985) Hyperbaric oxygen and multiple sclerosis: short-term results of a placebo-controlled, double-blind trial. Lancet i:297–300

    Article  Google Scholar 

  2. Basten A, McLeod JG, Pollard JD, Walsh JC, Stewart GJ, Garrick R, Frith JA, van der Brink CM (1980) Transfer factor in treatment of multiple sclerosis. Lancet ii:931–934

    Article  Google Scholar 

  3. Bever CT, Salazar AM, Neely E, Ferraraceio BE, Rose JW, McFarland HF, Levy HB, McFarlin DE (1986) Preliminary trial of poly ICLC in chronic progressive multiple sclerosis. Neurology (NY) 36:494–498

    Google Scholar 

  4. Bornstein MB, Miller A, Slagle S, et al. (1987) Copolymer I in exacerbating-remitting multiple sclerosis. N Engl J Med, (in press)

    Google Scholar 

  5. Bowern N, Ramshaw IA, Clark IA, Doherty PC (1984) Inhibition of autoimmune neuropathological process by treatment with an iron-chelating agent. J Exp Med 160:1532–1543

    Article  PubMed  CAS  Google Scholar 

  6. Cook SD, Devereux C, Troiano R, Hafstein MP, Zito G, Hernandez E, Lavenhar M, Vidaver R, Dowling PC (1986) Effect of total lymphoid irradiation in chronic progressive multiple sclerosis. Lancet i: 1405–1409

    Article  Google Scholar 

  7. Dworkin RH, Bates D, Millar JHD, Paty DW (1984) Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. Neurology (NY) 34:1441–1445

    CAS  Google Scholar 

  8. Chezzi A, Zaffaroni M, Caputo D, Marforio S, Guaschino R, Polverelli M, Cisari C, Cazzullo CL (1985) Lymphocytoplasmapheresis (LPA) in multiple sclerosis: one year follow-up of six patients. J Neurol [Suppl] 232:46

    Google Scholar 

  9. Gonsette RE (1985) Combined acute and chronic immunotherapy with cyclophosphamide (Endoxan) in multiple sclerosis. Eur Neurol 24: 437

    Google Scholar 

  10. Gonsette RE, Demonty L, Delmotte P (1977) Intensive immunosuppression with cyclophosphamide in multiple sclerosis: a follow-up of 110 patients for 2–6 years. J Neurol 214:173–181

    Article  PubMed  CAS  Google Scholar 

  11. Gonsette RE, Demonty L, Delmotte P, Decree J, de Cock W, Verhaeghen H, Symoens J (1982) Modulation of immunity in multiple sclerosis: a double-blind levamisole-placebo controlled study in 85 patients. J Neurol 228:65–72

    Article  PubMed  CAS  Google Scholar 

  12. Goodkin DE, Plencner S, Palmer-Saxerud J, Teetzen M, Hertsgaard D (1986) Cyclophosphamide in chronic progressive MS: maintenance versus non-maintenance therapy. Neurology [Suppl] (NY) 36:184

    Google Scholar 

  13. Hafler DA, Fallis RJ, Dawson DM, Schlossman SF, Reinherz EL, Weiner HL (1985) Pilot study of anti-pan-T-cell monoclonal antibodies for the treatment of progressive multiple sclerosis. Neurology [Suppl] (NY) 35:103

    Google Scholar 

  14. Hafler DA, Hemler ME, Christenson L, Williams JM, Shapiro HM, Strom TB, Strominger JL, Weiner HL (1985) Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin Immunol Immunopathol 37:163–171

    Article  PubMed  CAS  Google Scholar 

  15. Harpur GD, Suke R, Bass MJ, Bull SB, Reese L, Noseworthy JH, Rice GPA, Ebers GC (1986) Hyperbaric oxygen therapy in chronic stable multiple sclerosis: double-blind study. Neurology (NY) 36:988–991

    CAS  Google Scholar 

  16. Hauser SL, Dawson DM, Lehrich JR, Beal MF, Kevy SV, Propper RD, Mills JA, Weiner HL (1983) Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. N Engl J Med 308:173–180

    CAS  Google Scholar 

  17. Hauser SL, Fosburg M, Kevy SV, Weiner HL (1984) Lymphocytapheresis in chronic progressive multiple sclerosis: immunologic and clinical effects. Neurology (NY) 34:922–926

    CAS  Google Scholar 

  18. Hommes OR (1985) Short-term high-dose therapy with cyclophosphamide in chronic progressive MS patients with special attention to side-effects. Eur Neurol 24:438–439

    Google Scholar 

  19. Hommes OR, Lamers KJB, Reekers P (1980) Effect of intensive immunosuppression on the course of chronic progressive multiple sclerosis. J Neurol 223:177–190

    Article  Google Scholar 

  20. Huston DP, White MJ, Dressler RB, Rivera VM, Cooper B, Killian JM (1983) Immunosuppression for multiple sclerosis. N Engl J Med 309: 240–241

    Google Scholar 

  21. Jacobs L, O’Malley JA, Freeman A, Ekes R, Reese PA (1985) Intrathecal interferon in the treatment of multiple sclerosis. Patient follow-up. Arch Neurol 42:841–847

    Article  PubMed  CAS  Google Scholar 

  22. Johnson KP, Belendiuk G (1985) Use of cyclosporine in neurological autoimmune disease? Arch Neurol 42:1043–1044

    Article  PubMed  CAS  Google Scholar 

  23. Knobler RL, Panitch HS, Barheny SL, Sipe JC, Rice GPA, Huddle-stone JR, Francis GS, et al. (1984) Clinical trial of natural alpha interferon in multiple sclerosis. Ann NY Acad Sci 436:383–388

    Article  Google Scholar 

  24. Lhermitte F, Marteau R, Roullet E, de Saxce H, Loridan M (1984) Traitement prolongé de la sclérose en plaques par l’azathioprine à doses moyennes. Bilan de quine années d’expérience. Rev Neurol (Paris) 10:553–558

    Google Scholar 

  25. Medaer R, Raus J, Vermijlen C (1985) Lymphocytapheresis therapy in multiple sclerosis, clinical and immunological evaluation. J Neurol [Suppl] 232:125

    Google Scholar 

  26. Mertin J (1985) Completed double-blind trial with azathioprine. Final results and implications for the design of future studies. Eur Neurol 24:434

    Google Scholar 

  27. Mertin J, Rudge P, Kremer M, Healey MJR, Knight SC, Compston A, Batchelor JR, et al. (1982) Double-blind controlled trial of immunosuppression in the treatment of multiple sclerosis: final report. Lancet:351–354

    Google Scholar 

  28. Neiman J, Nilsson B, Barr PO, Perrins DJD (1985) Hyperbaric oxygen in chronic progressive multiple sclerosis: visual evoked potentials and clinical effects. J Neurol Neurosurg Psychiatry 48: 497–500

    Article  PubMed  CAS  Google Scholar 

  29. Deleted

    Google Scholar 

  30. Panitch HS, Haley AS, Hirsch RL, Johnson KP (1986) A trial of gamma interferon in multiple sclerosis: clinical results. Neurology [Suppl] (NY) 36:285

    Google Scholar 

  31. Patzold U (1985) Long-term treatment of azathioprine in multiple sclerosis. Results of a controlled follow-up study. Eur Neurol 24:434–435

    Google Scholar 

  32. Pompidou A, Rancurel G, Delsauw MC, Telvi L, Cour V, Buge A (1986) Amelioration clinique et immunologique des scleroses en plaques à forme rémittente par l’isoprinosine. Etude pilote randomisée. Presse Med 15:930–931

    PubMed  CAS  Google Scholar 

  33. Steinberg AD (1984) Cyclophosphamide. Should it be used daily, monthly or never? N Engl J Med 310:458–459

    Article  PubMed  CAS  Google Scholar 

  34. Trotter JL, Clifford DB, Montgomery EB, Ferguson TB (1985) Thymectomy in multiple sclerosis: a 3-year follow-up. Neurology (NY) 25: 1049–1051

    Google Scholar 

  35. Van Haver H, Lissoir F, van Hees J, Ketelaer P, Gautama K, Vande-putte I, Vermylen C, Theys P, Carton H (1985) Transfer factor treatment in multiple sclerosis: final results of a three year prospective double blind placebo controlled clinical trial (1982–1985). J Neurol [Suppl] 232:49

    Google Scholar 

  36. Warren KG, Catz I (1986) Diagnostic value of cerebrospinal fluid anti-myelin basic protein in patients with multiple sclerosis. Ann Neurol 20:20–25

    Article  PubMed  CAS  Google Scholar 

  37. Weiner HL (1985) An assessment of plasma exchange in progressive multiple sclerosis. Neurology (NY) 35:320–322

    CAS  Google Scholar 

  38. Weiner HL, Hauser SL, Hafler DA, Fallis RJ, Lehrich JR, Dawson DM (1984) The use of cyclophosphamide in the treatment of multiple sclerosis. Ann NY Acad Sci 436:373–381

    Article  PubMed  CAS  Google Scholar 

  39. Zeeberg IE, Heltberg A, Fog T (1985) Follow-up evaluation after at least two years treatment with azathioprine in a double-blind trial. Eur Neuol 24:435–436

    Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Gonsette, R.E., Demonty, L. (1987). Immunotherapy in Multiple Sclerosis: Fact or Fancy?. In: Poeck, K., Hacke, W., Schneider, R. (eds) Neuroimmunologie Spinale Krankheiten Neuropsychologie Metabolische Enzephalopathien Neurologische Notfälle Interventionelle Neuroradiologie. Verhandlungen der Deutschen Gesellschaft für Neurologie, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83201-7_11

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  • DOI: https://doi.org/10.1007/978-3-642-83201-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18254-2

  • Online ISBN: 978-3-642-83201-7

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