Abstract
The rationale for clinical application of whole-body thermochemotherapy is based on preclinical data suggesting the possibility of thermal enhancement of selectivity of the cytotoxic action of anticancer drugs (Honess 1983; Neumann et al. 1985b).
Supported by the Bundesministerium fur Jugend, Familie und Frauen und Gesundheit, Bonn.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alberts S, Peng YM, Chen HSG, Moon TE, Cetas TC, Hoschele ID (1980) Therapeutic synergism of hyperthermia-cis-platinum in a mouse tumor model. JNCI 65: 455–461
Barlogie B, Corry PM, Drewinko B (1980) In vitro thermochemotherapy of human colon cancer cells with cis-dichlorodiammineplatinum(II) and mitomycin-C. Cancer Res 40: 1165–1168
Cavaliere R, Difllippo F, Varanese A, Carlini S, Calabro A, Aloe L, Piarulli L (1984) Lonidamine and hyperthermia: clinical experience in melanoma. Preliminary results. Oncology [Suppl 1] 41: 116–120
Chlebowski RT, Block JB, Cundiff D, Dietrich MF (1982) Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line. Cancer Treat Rep 66:121–125
Hahn GM (1979) Potential for therapy of drugs and hyperthermia. Cancer Res 39: 2264–2268
Hahn GM, Braun J, Har-Kedar I (1975) Thermochemotherapy: Synergism between hyperthermia (42-43° C) and Adriamycin (or bleomycin) in mammalian cell inactivation (cancer chemotherapy/ cell membranes). Proc Natl Acad Sci USA 72: 937–940
Hinkelbein W, Menger D, Birmelin M, Engelhardt R (1984)The influence of whole-body hyperthermia on myelotoxicity of doxorubicin and irradiation in rats. In: Overgaard J. (ed) Proceedings of the 4th International Symposium on Hyperthermic Oncology, vol 1. Taylor and Francis, London, pp 281–283
Honess DJ (1983)Animal models in the evaluation of therapeutic gain of thermo-chemotherapy. In: Spitzy KH, et al., (eds) Proceedings of the 13th International Congress of Chemotherapy. Egermann, Vienna, pp 273/15-273/18
Kamura T, Aoki K, Nishikawa K, Baba T (1979) Antitumor effect of thermodifferential chemotherapy with carboquone on Ehrlich carcinoma. Gann 70: 783–790
Klein ME, Frayer K, Bachur NR (1977) Hyperthermic enhancement of chemotherapeutic agents in LI210 leukemia. Blood [Suppl 1] 50: 223
Leith JT, Heyman P, de Wyngaert JK, Dexter DL, Calabresi P, Glicksman AS (1983) Thermal survival characteristics of cell subpopulations isolated from a heterogeneous colon tumor. Cancer Res 43:3240–3246
Mella O (1985) Combined hyperthermia and cis-diamminedichloroplatinum in BD IX rats with transplanted BT4A tumors. Int J Hyperthermia 1:171–183
Mella O, Eriksen R, Dahl O, Laerum OD (1984)Therapy effects and toxicity of hyperthermia and cis-platin in BD IX rats with a transplantable neurogenic tumour (BT4A). In: Overgaard J. (ed) Proceedings of the 4th International Symposium on Hyperthermic Oncology, vol 1. Taylor and Francis, London, pp 413–416
Miller AB, Hoogstraten B, Staquet M, Winkler A (1981) Reporting results of cancer treatment. Cancer 47: 207–214
Mizuno S, Ishida A (1982) Selective enhancement of the cytotoxicity of the bleomycin derivate peplomycin by local anesthetics alone and combined with hyperthermia. Cancer Res 42: 4726–4729
Neumann HA, Fiebig HH, Engelhardt R, Löhr GW (1985 a) Cytostatic drug effects on human clonogenic tumor cells and human bone marrow progenitor cells (CFU-C) in vitro. Res Exp Med 185: 51–56
Neumann HA, Fiebig HH, Lohr GW, Engelhardt R (1985b) Effects of cytostatic drugs and 40.5° C hyperthermia on human bone marrow progenitors (CFU-C) and human clonogenic tumor cells implated into mice. JNCI 75:1059–1066
Neumann HA, Fiebig HH, Lohr GW, Engelhardt R (1985c) Effects of cytostatic drugs and 40.5° C hyperthermia on human clonogenic tumor cells. Eur J Cancer Clin Oncol 21: 515–523
Overgaard J (1976) Combined Adriamycin and hyperthermia treatment of a murine carcinoma in vivo. Cancer Res 36: 3077–3081
Robins HI, Longo WL, Gillis W, O’Keefe S, Shecterle LM, Hugander AH, Martin PA, Schmidt G, Dennis WH (1986) Preliminary results of a phase I study combining 41.8° C whole body hyperthermia (WBH) and lonidamine (Lon) (Abstr 138). Proc Am Soc Clin Oncol 5: 36
Rotstein LE, Daly J, Rozsa P (1983) Systemic thermochemotherapy in a rat model. Can J Surg 26: 113–116
Runge HM, Neumann HA, Buecke W, Pfleiderer A (1985) Cloning ovarian carcinoma cells in an agar double layer versus a methylcellulose monolayer system. A comparison of two methods. J Cancer Res Clin Oncol 110: 51–55
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Additional information
Dedicated to Prof. Dr. med. G. W. Löhr on the occasion of his 65th birthday. Supported by the Bundesministerium fü1r Jugend, Familie und Frauen und Gesundheit, Bonn.
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Engelhardt, R. (1988). Summary of Recent Clinical Experience in Whole-Body Hyperthermia Combined with Chemotherapy. In: Issels, R.D., Wilmanns, W. (eds) Application of Hyperthermia in the Treatment of Cancer. Recent Results in Cancer Research, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83260-4_29
Download citation
DOI: https://doi.org/10.1007/978-3-642-83260-4_29
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83262-8
Online ISBN: 978-3-642-83260-4
eBook Packages: Springer Book Archive