Abstract
Treatment of acute myocardial infarction with plasminogen activators reduces infarct size and mortality [1]. However, this form of therapy has been attended by significant problems. Urokinase and streptokinase lack fibrin selectivity and promote generalized fibrinogenolysis, at times resulting in severe bleeding [2]. Tissue-type plasminogen activator (TPA) and single-chain urokinase-type plasminogen activator (prourokinase) are both reported to be more clot-specific [3, 4]. In contrast to TPA, relatively few patients have been treated with prourokinase, and therefore experience with respect to the fibrin specificity and thrombolytic efficacy of this drug in a clinical situation is limited [5, 6, 7]. This study was undertaken in order to prove whether or not prourokinase is an effective, clot-selective fibrinolytic agent in patients with acute myocardial infarction.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Gruppo Italiano per lo Studio della Streptochinasi nell’ Infarto Miocardico (GISSI) (1986) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet I: 397–401
Laffel GL, Braunwald E (1987) Thrombolytic therapy: a new strategy for the treatment of acute myocardial infarction. N Engl J Med 311:710–717, 770–776
Collen D (1985) Human tissue-type plasminogen activator: from the laboratory to the bedside. Circulation 72: 18–20
Pannel R, Gurewich V (1986) Pro-urokinase: a study of its stability in plasma and of a mechanism for its selective fibrinolytic effect. Blood 67: 1215–1223
Van de Werf F, Nobuhara M, Collen D (1986) Coronary thrombolysis with human single-chain urokinase-type plasminogen activator (prourokinase) in patients with myocardial infarction. Ann Intern Med 104: 345–348
Bode C, Schuler G, Schwarz F, Zimmermann R, Horn A, Kübler W (1987) Usefulness of intravenous thrombolytic therapy with prourokinase in acute myocardial infarction. Am J Cardiol 60: 371
Van de Werf F, Vanhaecke J, DeGeest H, Verstraete M, Collen D (1986) Coronary thrombolysis with recombinant single-chain urokinase-type plasminogen activator in patients with acute myocardial infarction. Circulation 74: 1066–1070
Collen D, Stump D, Van de Werf F (1986) Coronary thrombolysis in patients with acute myocardial infarction by intravenous infusion of synergic thrombolytic agents. Am Heart J 112: 1083–1084
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Bode, C. et al. (1988). Prourokinase in Acute Myocardial Infarction: Is it Effective?. In: Schettler, G., Jennings, R.B., Rapaport, E., Wenger, N.K., Bernhardt, R. (eds) Reperfusion and Revascularization in Acute Myocardial Infarction. Supplement zu den Sitzungsberichten der Mathematisch-naturwissenschaftlichen Klasse Jahrgang 1988, vol 1988 / 1988/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83544-5_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-83544-5_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83546-9
Online ISBN: 978-3-642-83544-5
eBook Packages: Springer Book Archive