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Complexities in Gene Regulation by Promoter Methylation

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Nucleic Acids and Molecular Biology

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 3))

Abstract

The regulation of eukaryotic gene expression presents a multi-faceted problem. It is not limited to the extreme stages of a gene being turned on or switched off. Regulation of gene expression also implies the facility of gene activity to be modulated to various degrees and of promoters to be capable of responding to a variety of internal and environmental stimuli. These stringent requirements can be met by promoter sequences in that they exhibit genetic signals which can be recognized by a considerable number of cellular regulatory proteins. Such promoter signals being vacant or occupied by a specific protein or several proteins confer a certain state of activity upon the promoter and the gene it controls. A multitude of cellular proteins and of promoter signals appear to be involved in the regulation of gene activity. Regulatory significance is not restricted to DNA-protein interactions. Proteinprotein binding may be as important in that promoter-binding proteins might acquire the promoter-congruent conformation by a previous interaction with other proteins. Alternatively, reaching this conformation could be prohibited by linkage to yet other proteins thus obstructing the essential DNA-protein interaction.

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Authors and Affiliations

  1. Institut für Genetik, Universität zu Köln, Weyertal 121, 5000, Köln 41, Germany

    Walter Doerfler

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  1. Walter Doerfler
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  1. Abteilung Chemie, Max-Planck-Institut für experimentelle Medizin, Hermann-Rein-Straße 3, 3400, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, DD1 4HN, Dundee, UK

    David M. J. Lilley

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© 1989 Springer-Verlag Berlin Heidelberg

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Doerfler, W. (1989). Complexities in Gene Regulation by Promoter Methylation. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83709-8_7

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  • DOI: https://doi.org/10.1007/978-3-642-83709-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83711-1

  • Online ISBN: 978-3-642-83709-8

  • eBook Packages: Springer Book Archive

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