Skip to main content

Erythrocytosis in Renal Graft Recipients

  • Conference paper
Erythropoietin
  • 103 Accesses

Abstract

Anemia develops during the course of chronic renal failure with deterioration of excretory kidney function [1–3]. Erythropoietin (EPO) deficiency [1, 2] and uremic bone marrow intoxication [4, 5] have been implicated as major causative factors for the development of renal anemia. This concept is supported by the observation that shortly after kidney transplantation, and in the presence of good kidney function, most if not all transplant patients overcome their anemic state; their hematocrits once again begin to build up to become normal or close to normal [6, 7]. However, in some patients the hematocrit continues to rise even after complete correction of anemia, resulting in post-transplant erythrocytosis (PTE) [6–9].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Eschbach JW, Funk P, Adamson J, Scribner BH, Finch CA (1967) Eryhtropoiesis in patients with renal failure undergoing chronic dialysis. N Engl J Med 276: 653–658

    Article  PubMed  Google Scholar 

  2. Erslev AJ (1970) Anemia of chronic renal desease. Arch Intern Med 126: 774–780

    Article  PubMed  CAS  Google Scholar 

  3. Radtke HW, Claussner A, Erbes PM, Scheuermann EH, Schoeppe W, Koch KM (1979) Serum erythropoietin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function. Blood 54: 877–884

    PubMed  CAS  Google Scholar 

  4. Ohno Y, Rege AB, Fisher JW, Barona J (1978) Inhibition of erythroid colony forming cells (CFU-E and BFU-E) in sera of azotemic patients with anemia of renal diseases. J Lab Clin Med 92: 916–923

    PubMed  CAS  Google Scholar 

  5. Radtke HW, Rege AB, La Marche MB, Bartos D, Bartos F, Campbell RA, Fisher JW (1981) Identification of spermine as an inhibitor of erythropoiesis in patients with chronic renal failure. J Clin Invest 67: 1623–1629

    Article  PubMed  CAS  Google Scholar 

  6. Herforth A, Binswanger U, Largiader F, Frick P (1979) Hohe Haemoglobinkonzentration und hoher Haematokrit bei Traegern von Nierenallotransplantaten. Schweiz Med Wochenschr 109: 1293–1298

    PubMed  CAS  Google Scholar 

  7. Dagher FJ, Ramos E, Erslev AJ, Alongi SV, Karmi SA, Caro J (1979) Are the native kidneys responsible for erythrocytosis in renal allografts? Transplantation 28: 496–498

    PubMed  CAS  Google Scholar 

  8. Varkarakis MJ, Sampson D, Gerbas JR, Bender MA, Mirand EA, Murphy GP (1971) Polycythemia following renal transplantation unrelated to the allograft. J Surg Oncol 3: 157–161

    Article  PubMed  CAS  Google Scholar 

  9. Ianhez LE, Da Fonseca JA, Chocair P, Maspes V, Sabbage E (1977) Polycythemia after kidney transplantation. Influence of the native kidneys on the production of hemoglobin. Urol Int 32: 382–392

    Article  Google Scholar 

  10. Wu KK, Gibson TK, Freemann RM (1971) Erythrocytosis after renal transplantation. Its occurrence in two recipients of kidneys from the same cadaveric donor. Arch Intern Med 132: 898–902

    Article  Google Scholar 

  11. Tarvazi RC, Froehlich ED, Dustan HP (1966) Hypertension and high hematocrit. Am J Cardiol 18: 855–858

    Article  Google Scholar 

  12. Luke RG, Kennedy AC, Stirling WB, McDonald GA (1965) Renal artery stenosis, hypertension and polycythemia. Br Med J 1: 164–166

    Article  PubMed  CAS  Google Scholar 

  13. Thevenod F, Radtke HW, Gruetzmacher P, Vincent E, Koch KM, Schoeppe W, Fassbinder W (1983) Deficient feedback regulation of erythropoiesis in kidney transplant patients with polycythemia. Kidney Int 24: 227–232

    Article  PubMed  CAS  Google Scholar 

  14. Mirand EA, Murphy GP (1975) Erythropoietin alterations in patients with uremia, renal allograft or without kidneys. JAMA 209: 327–334

    Google Scholar 

  15. Eckardt KU, Kurtz A, Hirth P, Scigalla P, Wieczorek L, Bauer C (1988) Evaluation of the stability of human erythropoietin in samples for radioimmunoassay. Klin Wochenschr 66: 241–245

    Article  PubMed  CAS  Google Scholar 

  16. Fauser AA, Messner HA (1978) Granuloerythropoietic colonies in human bone marrow, peripheral blood and cord blood. Blood 52: 1243–1248

    PubMed  CAS  Google Scholar 

  17. Mollison PL, Engelfriet CP, Contreras M (1979) Antigens on leucocytes, platelets and serum proteins. In: Blood transfusion in clinical medicine, 6th ed Alden, Oxford, pp 690–697

    Google Scholar 

  18. Ginn HE (1972) Late medical complications of renal transplantation. Arch Intern Med 116: 6–15

    Google Scholar 

  19. Prompt CA, Lee DBN, Upham AT (1977) Medical complications of renal transplantation. II. Non-infectious complications in recipient. Urology 9 [Suppl]: 32–48

    PubMed  CAS  Google Scholar 

  20. Chisholm GD (1973) Complications of renal transplantation. Proc R Soc Med 66: 914–918

    PubMed  CAS  Google Scholar 

  21. Fisher JW (1972) Erythropoietin: pharmacology, biogenesis and control of production. Pharmacol Rev 24: 459–501

    PubMed  CAS  Google Scholar 

  22. Napier JAF, Janowska-Wieczorek A (1981) Erythropoietin measurements in the differential diagnosis of polycythemia. Br J Haematol 48: 393–401

    Article  PubMed  CAS  Google Scholar 

  23. Erslev AJ, Caro J, Miller O, Cobbs E (1979) Plasma erythropoietin in polycythemia. Am J Med 66: 243–247

    Article  PubMed  CAS  Google Scholar 

  24. Lamperi S, Carozzi S, Manca F, Valente U (1985) Erythropoietin-independent erythropoiesis in polycythemic transplanted patients. Transplant Proc 17: 86–88

    Google Scholar 

  25. Shalhoub RJ, Rajan U, Kim VV, Goldwasser E, Kark J, Antoniou LP (1982) Erythrocytosis in patients on long term hemodialysis. Ann Intern Med 97: 686–690

    PubMed  CAS  Google Scholar 

  26. Gregory CJ, Eaves AC (1977) Human marrow cells capable of erythropoietic differentiation in vitro: definition of three erythroid colony responses. Blood 49: 855

    PubMed  CAS  Google Scholar 

  27. Raghavachar A, Frickhofen N, Arnold R, Schmeiser T, Porzsolt F, Heimpel H (1986) Hematopoietic colony formation after allogeneic bone marrow transplantation: enhancement by cyclosporin A and anti-gamma-(immune) interferon antiserum in vitro. Exp Hematol 14: 621–625

    PubMed  CAS  Google Scholar 

  28. Frassoni F, Bacigalupo A, Piaggio G, Podesta M, Repetto M, Marmont AM (1985) Effect of cyclosporin A (CyA) on the in vitro growth of hemopoietic progenitors from normal marrow. Exp Hematol 13: 1084–1088

    PubMed  CAS  Google Scholar 

  29. Stockenhuber F, Geissler K, Sunder-Plassmann G, Kurz RW, Steininger R, Muehlbacher F, Hinterberger W, Balcke P: Erythrocytosis in renal graft recipients is not due to elevated erythropoietin serum concentrations. Transplant Proc (in print)

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Stockenhuber, F., Geissler, K., Hinterberger, W., Balcke, P. (1989). Erythrocytosis in Renal Graft Recipients. In: Jelkmann, W., Gross, A.J. (eds) Erythropoietin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83745-6_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83745-6_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83747-0

  • Online ISBN: 978-3-642-83745-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics