Skip to main content

Role of Gangliosides in the Modulation of the Angiogenic Response

  • Conference paper
Cancer Therapy

Part of the book series: NATO ASI Series ((ASIH,volume 75))

  • 79 Accesses

Abstract

The unrestrained growth and metastatic potential of a tumor is strictly correlated to its capacity to induce an efficient capillary network in the host tissue (Folkman J and Cotran R 1976, Ziehe M and Gullino PM, 1982). Under physiological circumstances the ability of a given tissue to produce a neovascular response is under strict controll, i.e. the balance between factors and events favoring or interfering with neovascular growth is in equilibrium.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alessandri G, Raju KS, Gullino PM (1986) Interaction of gangliosides with fibronectin in the mobilization of capillary endothelium. Invasion Metastasis 6: 145–165.

    PubMed  CAS  Google Scholar 

  • Alessandri G, De Cristian G, Ziehe M, Cappa APM, Guliino PM (1992) Growth and motility of microvascular endothelium are modulated by the relative concentration of gangliosides in the medium. J Cell Physiol 151: 23–28

    Article  PubMed  CAS  Google Scholar 

  • Alessandri G, Raju KS, Guliino PM (1984) Angiogenesis in vivo and selective mobilization of capillary endothelium in vitro by heparin-copper complex. Microcirculation, Endothelium adn Lymphatics 1: 329–346

    Google Scholar 

  • De Cristian G, Morbidelli L, Alessandri G, Ziehe M, Cappa APM, Guliino PM (1990) Synergism between gangliosides and basic fibroblast growth factor in favouring survival, growth and motility of capillary endothelium. J Cell Physiol 144: 505–510

    Article  Google Scholar 

  • Folkman J, Cotran R (1976) Relation of vascular proliferation to tumor growth. Int Rev Exp Pathol 16: 207.

    PubMed  CAS  Google Scholar 

  • Folkman J, Klagsburn M (1987) Angiogenic factors. Science 235: 442–447

    Article  PubMed  CAS  Google Scholar 

  • Guliino PM (1981) Angiogenesis factors “in: Baserga R (ed) Handbook Exp Pharmacology” Springer Verlag, New York, 57: 427–449

    Google Scholar 

  • Langer R, and Folkman J (1976) Polymers for the sustained release of proteins and other macromolecules. Nature 263: 797–800

    Article  PubMed  CAS  Google Scholar 

  • Vlodawskyl, Fuks Z, Ishai-Michael R, Baskin P, Levi E, Korner G, Bar-Shavit R, Klagsburn M (1991) Extracellular-matrix-resident fibroblastic growth factor: implication for control of angiogenesis. J Cell Biochem 45: 167–176

    Article  Google Scholar 

  • Ziche M, Jones J, Guliino PM (1982) Role of Prostaglandin E1 and copper in angiogenesis. J Natl Cancer Inst 69: 475–482

    PubMed  CAS  Google Scholar 

  • Ziche M, and Guliino PM (1982) Angiogenesis and neoplastic progression in vitro. J Natl Cancer Inst 69: 483–487

    PubMed  CAS  Google Scholar 

  • Ziche M, Alessandri G, Guliino PM (1989) Gangliosides promote the angiogenic response. Lab Inv 61: 629–634

    CAS  Google Scholar 

  • Ziche M, Morbidelli L, Alessandri G, Guliino PM (1992) Angiogenesis can be stimulated in vivo by a change in the GM3.GD3 ganglioside ratio. Lab Inv in press

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Ziche, M., Morbidelli, L., Parenti, A., Alessandri, G., Ledda, F., Gullino, P.M. (1993). Role of Gangliosides in the Modulation of the Angiogenic Response. In: D’Alessandro, N., Mihich, E., Rausa, L., Tapiero, H., Tritton, T.R. (eds) Cancer Therapy. NATO ASI Series, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84613-7_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84613-7_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84615-1

  • Online ISBN: 978-3-642-84613-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics