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Diversity of Epithelial Skin Tumors: Thoughts and Comments on Some Basic Principles

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Skin Carcinogenesis in Man and in Experimental Models

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 128))

Abstract

The diagnosis of any skin tumor depends upon a spectrum of clinical and histopathological criteria which must be fitted by the individual case. This means that both the classification scheme and the use of analogy only work if the tumors were different from each other. On the other hand, we know that at least some if not all epithelial skin tumors have a certain amount of intraindividual heterogeneity.

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References

  • Aaronson SA, Rubin JS, Finch PW, Wong J, Marchese C, Falco J, Taylor WG, Kraus MH (1990) Growth factor-regulated pathways in epithelial cell proliferation. Am Rev Respir Dis 142: S7–S10

    PubMed  CAS  Google Scholar 

  • Albini A, Iwamoto Y, Kleiman HK, Martin GR, Aaronson SA, Kozlowski JM, McEwan RN (1987) A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 47: 3239–3245

    PubMed  CAS  Google Scholar 

  • Anderson H (1990) Adhesion molecules and animal development. Experientia 46: 2–13

    Article  PubMed  CAS  Google Scholar 

  • Avesti C, Grossin M, Toublanc M, Benjereb N, Bourgeois-Droin C, Delacretaz J, Belaich S, Bocquet L (1990) Association d’un carcinome neuro-endocrine cutané et d’une maladie de Bowen. Revue de la littérature à propos de quatre cas. Ann Pathol 10: 86–98

    Google Scholar 

  • Beresford WA (1990) Direct transdifferentiation: can cells change their phenotype without dividing? Cell Differ Dev 29: 81–93

    Article  PubMed  CAS  Google Scholar 

  • Bhargava PM, Chandani SA (1988) Regulation of cell division and malignant transformation. Biosci Rep 8: 519–529

    Article  PubMed  CAS  Google Scholar 

  • Bogenmann E, Jones PA (1983) Role of plasminogen in matrix breakdown by neoplastic cells. J Natl Cancer Inst 71: 1177–1182

    PubMed  CAS  Google Scholar 

  • Bosco L (1988) Transdifferentiation of ocular tissues in larval Xenopus laevis. Differentiation 39: 4–15

    Article  PubMed  CAS  Google Scholar 

  • Chigira M, Noda K, Watanabe H (1990) Autonomy in tumor cell proliferation. Med Hypotheses 32: 249–254

    Article  PubMed  CAS  Google Scholar 

  • Cotsarelis G, Sun T-T, Lavker R (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61: 1329–1337

    Article  PubMed  CAS  Google Scholar 

  • Dedhar S (1990) Integrins and tumor invasion. Bioessays 12: 583–590

    Article  PubMed  CAS  Google Scholar 

  • Donaldson DJ, Mahan JT, Smith GN Jr (1987) Newt epidermal cell migration in vivo and in vitro appears to involve Arg-Gly-Asp-Ser receptors. J Cell Sci 87: 525–534

    PubMed  CAS  Google Scholar 

  • Eedy DJ, Johnston CF, Shaw C, Buchanan KD (1991) Neuropeptides in psoriasis: an immunocytochemical and radioimmunoassay study. J Invest Dermatol 96: 434–438

    Article  PubMed  CAS  Google Scholar 

  • Ekblom P (1989) Developmentally regulated conversion of mesenchyme to epithelium. FASEB J 3: 2141–2150

    PubMed  CAS  Google Scholar 

  • El-Labban NG, Osorio-Herrera E (1986) Apoptotic bodies and abnormally dividing epithelial cells in squamous cell carcinoma. Histopathology 10: 921–931

    Article  PubMed  CAS  Google Scholar 

  • Fenderson BA, Eddy EM, Hakomori S (1990) Glycoconjugate expression during embryogenesis and its biological significance. Bioessays 12: 173–179

    Article  PubMed  CAS  Google Scholar 

  • Goodland RA, Wright NA (1989) Peptides and epithelial growth regulation. Experientia Suppl 56: 180–191

    Article  Google Scholar 

  • Gould V, Moll R, Moll I, Lee I, Franke WW (1985) Neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias, and neoplasms. Lab Invest 52: 334–353

    PubMed  CAS  Google Scholar 

  • Gould E, Albores-Saavedra J, Dubner B, Smith W, Payne CM (1988) Eccrine and squamous differentiation in Merkel cell carcinoma: an immunohistochemical study. Am J Surg Pathol 12: 768–772

    Article  PubMed  CAS  Google Scholar 

  • Grondahl-Hansen J, Lund LR, Ralfkiaer E, Ottevanger V, Dano K (1988) Urokinase-and tissue type plasminogen activators in keratinocytes during wound epithelialization in vivo. J Invest Dermatol 90: 790–795

    Article  PubMed  CAS  Google Scholar 

  • Guo JF, Brown R, Rothwell CE, Bernstein IA (1990a) Levels of cytochrome P-450-mediated aryl hydrocarbon hydroxylase ( AHH) are higher in differentiated than in germinative cutaneous keratinocytes. J Invest Dermatol 94: 86–93

    Google Scholar 

  • Guo M, Toda K, Grinnell F (1990b) Activation of human keratinocyte migration on type I collagen and fibronectin. J Cell Sci 96: 197–205

    PubMed  CAS  Google Scholar 

  • Haegerstrand A, Jonzon B, Dalsgaard C-J, Nilsson J (1989) Vasoactive intestinal polypeptide stimulates cell proliferation and adenylate cyclase activity of cultured keratinocytes. Proc Natl Acad Sci USA 86: 5993–5996

    Article  PubMed  CAS  Google Scholar 

  • Hashimoto K, Kanzaki T (1984) Appendage tumors of the skin: histogenesis and ultrastructure. J Cutan Pathol 11: 365–381

    Article  PubMed  CAS  Google Scholar 

  • Hashimoto K, Gross BG, Lever WF (1966) The ultrastructure of human embryo skin: II. The formation of the intradermal portion of the eccrine sweat duct and of the secretory segment during the first half of embryonic life. J Invest Dermatol 46: 513–529

    Google Scholar 

  • Hashimoto K, Mehregan AH, Kumakiri M (1987) Tumors of skin appendages. Butterworth, Stoneham

    Google Scholar 

  • Heenan PJ, Cole JM, Spagnolo DV (1990) Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor). An adnexal epithelial neoplasm. Am J Dermatopathol 12: 7–16

    Google Scholar 

  • Hill MW, Mackenzie IC (1989) The influence of subepithelial connective tissues on epithelial proliferation in the adult mouse. Cell Tissue Res 255: 179–182

    Article  PubMed  CAS  Google Scholar 

  • Iki M (1990) Immunohistochemical studies on eccrine sweat apparatus neoplasms. 2 An immunohistochemical study on eccrine sweat apparatus neoplasms—direction of differentiation in eccrine sweat apparatus neoplasms. Skin Res 32: 353–367

    Google Scholar 

  • Inohara A (1990) Protein kinase C in psoriasis. Skin Res 32: 339–344

    CAS  Google Scholar 

  • Jones TE, Munger BL (1987) Neural modulation of cutaneous differentiation: epidermal hyperplasia and precocious hair development following partial neuralectomy in opossum pups. Neurosci Lett 79: 6–10

    Article  PubMed  CAS  Google Scholar 

  • Kasper M (1991) Heterogeneity in the immunolocalization of cytokeratin specific monoclonal antibodies in the rat eye: evaluation of unusual epithelial tissue entities. Histochemistry 95: 613–620

    Article  PubMed  CAS  Google Scholar 

  • Kasper M, Moll R, Stosiek P, Karsten U (1988) Patterns of cytokeratin and vimentin expression in the human eye. Histochemistry 89: 369–377

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann R, Weber L, Klein CE (1990) Integrine — neue Rezeptormolekiile: Ihre Bedeutung für die Differenzierung, Regeneration and Immunantwort der Haut. Hautarzt 41: 256–261

    Google Scholar 

  • Kirchheimer JC, Wojta J, Christ G, Binder BR (1987) Proliferation of a human epidermal tumor cell line stimulated by urokinase. FASEB J 1: 125–128

    PubMed  CAS  Google Scholar 

  • Klein CE, Steinmayer T, Mattes JM, Kaufmann R, Weber L (1990) Integrins of normal human epidermis: differential expression, synthesis and molecular structure. Br J Dermatol 123: 171–178

    Article  PubMed  CAS  Google Scholar 

  • Knopf B, Wollina U (1992) Electrophoretic mobilities of keratinocytes from normal skin and psoriatic lesions. Arch Dermatol Res 284: 117–118

    Article  PubMed  CAS  Google Scholar 

  • Krueger JG, Krane JF, Carter DM, Gottlieb AB (1990) Role of growth factors, cytokines, and their receptors in the pathogenesis of psoriasis. J Invest Dermatol 94: 135s-140s

    Article  PubMed  CAS  Google Scholar 

  • Lavrijsen AP, Tieben LM, Ponec M, van der Schroeff JG, van Muijen GN (1989) Expression of EGF receptor, involucrin, and cytokeratins in basal cell carcinomas and squamous cell carcinomas of the skin. Arch Dermatol Res 281: 83–88

    Article  PubMed  CAS  Google Scholar 

  • Lever WF, Schaumburg-Lever G (1990) Histopathology of the skin, 7th edn. Lippincott, Philadelphia

    Google Scholar 

  • Mackenzie IC, Dabelsteen E (1987) Connective tissue influences on the expression of epithelial cell-surface antigens. Cell Tissue Res 248: 137–141

    Article  PubMed  CAS  Google Scholar 

  • Mahrle G (1982) Cell interactions and cell surface membranes in psoriasis. In: Farber EM, Cox AJ (eds) Psoriasis. Proceedings of the 3rd international symposium. Grune and Stratton, New York, pp 43–52

    Google Scholar 

  • Mahrle G, Runne U, Orfanos CE (1977) Sensorische Innervation und autonome Kontrolle der menschlichen Epidermis. In: Lassmann G, Niebauer G, Jurecka W (eds) Wiener Symposium “Struktur und Pathologie des Hautnervensystems”. Verband der wissenschaftlichen Gesellschaften Österreichs, Wien, pp VI/1—VI/7

    Google Scholar 

  • Marchisio PC, Bondanza S, Cremona O, Cancedda R, De Luca M (1991) Polarized expression of integrin receptors (alpha 6 beta 4, alpha 2 beta 1, alpha 3 beta 1, and alpha v beta 5) and their relationship with the cytoskeleton and basement membrane matrix in cultured human keratinocytes. J Cell Biol 112: 761–773

    Article  PubMed  CAS  Google Scholar 

  • Mehregan AH (1985) The origin of the adnexal tumors of the skin: a viewpoint. J Cutan Pathol 12: 459–467

    Article  PubMed  CAS  Google Scholar 

  • Merk HF (1990) Die Haut als Signalorgan in der Entwicklung neuer Zytostatika und Antitumorstrategien. Z Hautkr 65: 89–96

    PubMed  CAS  Google Scholar 

  • Merk H, Rumpf M, Bolsen K, Wirth H, Goerz G (1987a) Inducibility of arylhydrocarbon-hydroxylase activity in human hair follicles by topical application of liquor carbonic detergens (cool tar). Br J Dermatol 111: 279–284

    Article  Google Scholar 

  • Merk H, Mukhtar H, Schutte B, Kaufmann I, Das M, Bickers DR (1987b) 7Ethoxyresorufineethylase activity in human hair roots: a potential marker for toxifying species of cytochrome P-450 isoenzymes. Biochem Biophys Res Commun 148: 755–760

    Google Scholar 

  • Merot Y, Mooy A (1989) Merkel cell hyperplasia in hypertrophic varieties of actinic keratoses. Dermatologica 178: 189–193

    Article  PubMed  CAS  Google Scholar 

  • Miettinen M, Clark R, Virtanen I (1986) Intermediate filament proteins in choroid plexus and ependyma and their tumors. Am J Pathol 123: 231–240

    PubMed  CAS  Google Scholar 

  • Mizuno T, Yasugi S (1990) Susceptibility of epithelia to directive influences of mesenchymes during organogenesis: uncoupling of morphogenesis and cytodifferentiation. Cell Differ Dev 31: 151–159

    Article  PubMed  CAS  Google Scholar 

  • Moll R, Moll I, Franke WW (1984) Identification of Merkel cells in human skin by specific cytokeratin antibodies: changes of cell density and distribution in fetal and adult plantar epidermis. Differentiation 28: 136–154

    Article  PubMed  CAS  Google Scholar 

  • Moll I, Lane AT, Franke WW, Moll R (1990) Intraepidermal formation of Merkel cells on xenografts of human fetal skin. J Invest Dermatol 94: 359–364

    Article  PubMed  CAS  Google Scholar 

  • Morioka S, Lazarus GS, Baird JL, Jensen PJ (1987) Migrating keratinocytes express urokinase-type plasminogen activator. J Invest Dermatol 88: 418–423

    Article  PubMed  CAS  Google Scholar 

  • Mukhtar H, Khan WA (1989) Cutaneous cytochrome P-450. Drug Metab Rev 20: 657–673

    Article  PubMed  CAS  Google Scholar 

  • Mukhtar H, Merk HF, Athar M (1989) Skin chemical carcinogenesis. Clin Dermatol 7: 1–10

    Article  PubMed  CAS  Google Scholar 

  • Nakhleh RE, Swanson PE, Wick MR (1990) Cutaneous adnexal carcinomas with divergent differentiation. Am J Dermatopathol 12: 325–334

    Article  PubMed  CAS  Google Scholar 

  • Naukkarinen A, Nickoloff BJ, Farber EM (1989) Quantification of cutaneous sensory nerves and their substance P content in psoriasis. J Invest Dermatol 92: 126–129

    Article  PubMed  CAS  Google Scholar 

  • Oriol R (1987) ABH and related tissues. Biochem Soc Trans 15: 596–599

    PubMed  CAS  Google Scholar 

  • Pinkus H (1958) The concept of symbiosis applied to normal and abnormal growth in the human epidermis. Dermatologica 177: 369–379

    Article  Google Scholar 

  • Pittelkow MR, Lindquist PB, Abraham RT, Graves-Deal R, Deryck R, Coffey RJ Jr (1989) Induction of transforming growth factor-alpha expression in human keratinocytes by phorbol esters. J Biol Chem 264: 5164–5171

    PubMed  CAS  Google Scholar 

  • Poste G, Greig R (1986) The cell surface and cancer metastasis. In: Steinberg MS (ed) Developmental biology, vol 3. Plenum, New York, pp 15–31

    Google Scholar 

  • Reiners JJ Jr, Cantu AR, Pavone A (1990) Modulation of constitutive cytochrome P-450 expression in vivo and in vitro in murine keratinocytes as a function of differentiation and extracellular Ca2+ concentration. Proc Natl Acad Sci USA 87: 1825–1829

    Article  PubMed  CAS  Google Scholar 

  • Rorth P, Nerlov C, Blasi F, Johnsen M (1990) Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor of phorbol-ester. Nucleic Acids Res 18: 5009–5017

    Article  PubMed  CAS  Google Scholar 

  • Rosen LB (1990) A review and proposed new classification of benign acquired neoplasms with hair follicle differentiation. Am J Dermatopathol 12: 496–516

    Article  PubMed  CAS  Google Scholar 

  • Ruben LN, Clothier RH, Horton JD, Balls M (1989) Amphibian metamorphosis: an immunologic opportunity! Bioessays 10: 8–12

    Article  PubMed  CAS  Google Scholar 

  • Sanders EJ (1991) Embryonic cell invasiveness: an in vitro study of chick gastrulation. J Cell Sci 98: 403–407

    PubMed  Google Scholar 

  • Schaarschmidt H, Wollina U (1990) Immunhistochemischer Nachweis von Calmodulin. Ein Beitrag zur histogenetischen Einordnung von ekkrinen Poromen and Klarzellakanthomen. Dermatol Monatsschr 176: 363–370

    Google Scholar 

  • Schmid V, Plickert G (1990) The proportion altering factor ( PAF) and the in vitro transdifferentiation of isolated striated muscle of jellyfish into nerve cells. Differentiation 44: 95–102

    Google Scholar 

  • Stamp GW, Pignatelli M (1991) Distribution of beta 1, alpha 1, alpha 2 and alpha 3 integrin chains in basal cell carcinomas. J Pathol 163: 307–313

    Article  PubMed  CAS  Google Scholar 

  • Steinberg MS (1986) Cell surfaces in the control of growth and morphogenesis. In: Steinberg MS (ed) Developmental biology, vol 3. Plenum, New York, pp 1–13

    Google Scholar 

  • Stolar A, Duvic M, Fuchs E (1989) Unusual patterns of keratin expression in the overlying epidermis of patients with dermatofibromas: biochemical alterations in the epidermis as a consequence of dermal tumors. J Invest Dermatol 93: 728–738

    Article  Google Scholar 

  • Sugiyama M, Komamine A (1990) Transdifferentiation of quiescent parenchymatous cells into tracheary elements. Cell Differ Dev 31: 77–87

    Article  PubMed  CAS  Google Scholar 

  • Tiedemann H (1990) Cellular and molecular aspects of embryonic induction. Zool Sci 7: 171–186

    CAS  Google Scholar 

  • Tsubura A, Morii S, Ueda S, Sasaki M, Zotter S, Wätzig V, Mooi W, Hagemann P, Hilkens J, van den Tweel J, Meijer C, Hilgers J (1987) Immunohistochemical demonstration of MAM-3 and MAM-6 antigens in normal human skin appendages and their tumors. Arch Dermatol Res 279: 550–557

    Article  PubMed  CAS  Google Scholar 

  • Vaigot P, Pisani A, Darmon YM, Ortonne JP (1987) The majority of epidermal Merkel cells are non-proliferative: a quantitative immunofluorescence analysis. Acta Derm Venereol (Stockh) 67: 517–541

    CAS  Google Scholar 

  • Wiley LM, Kidder GM, Watson AJ (1990) Cell polarity and development of the first epithelium. Bioessays 12: 67–73

    Article  PubMed  CAS  Google Scholar 

  • Wollina U (1988) Abnorme Epidermiszelldifferenzierung bei Psoriasis vulgaris. Thesis, Friedrich-Schiller-University, Jena

    Google Scholar 

  • Wollina U (1990) Immunohistochemical investigations in epidermal Merkel cells — a common phenotype with eccrine sweat gland epithelium. Acta Histochem 88: 47–50

    PubMed  CAS  Google Scholar 

  • Wollina U (1991a) Human eccrine sweat gland. Expression of neuroglandular antigen and coexpression of intermediate filaments. Histol Histopathol 6: 191–198

    PubMed  CAS  Google Scholar 

  • Wollina U (1991b) Ekkrine Schweißdrüsen — embryologische Aspekte and klinische Bezüge. Dermatol Monatsschr 177: 1–6

    Google Scholar 

  • Wollina U (1991c) Neuropeptide in der Dermatologie. Z Hautkrankh 66: 1010–1017

    Google Scholar 

  • Wollina U (1992) Histochemistry of the human hair follicle with consideration of anagen phases Ito IV. Acta Histochem 92: 171–178

    PubMed  CAS  Google Scholar 

  • Wollina U, Mahrle G (1992) Epidermal Merkel cells in psoriatic lesions — immunohistochemical investigations on frequency and neuropeptide expression. J Dermatol Sci 3: 145–150

    Article  PubMed  CAS  Google Scholar 

  • Wollina U, Schaarschmidt H (1990a) Chondroides Hidradenom. Immunhistologischer Nachweis von Zytokeratin and Calmodulin Dermatol Monatsschr 176: 173–178

    CAS  Google Scholar 

  • Wollina U, Schaarschmidt H (1990b) Das erworbene akrale Fibrokeratom. Hautarzt 41: 158–160

    PubMed  CAS  Google Scholar 

  • Wollina U, Klinger R, Wetzker R, Knopf B (1989a) Increase of epidermal calmodulin precedes the formation of a psoriatic lesion. Arch Dermatol Res 281: 73–74

    Article  PubMed  CAS  Google Scholar 

  • Wollina U, Klinger R, Wetzker R, Reissmann R, Knopf B (1989b) Immunohistological localization of calmodulin in normal and psoriatic epidermis. Arch Dermatol Res 280: 497–498

    Article  PubMed  CAS  Google Scholar 

  • Wollina U, Schaarschmidt H, Henkel U, Knopf B, Hipler C (1989c) Histochemische Untersuchungen zur transepidermalen Elimination von Nävuszellen. Z Hautkr 64: 694–699

    PubMed  CAS  Google Scholar 

  • Wollina U, Schaarschmidt H, Knopf B, Feldrappe S (1990) Immunhistologische Untersuchungen zur Verteilung proliferativer Kompartimente in den Anhangsgebilden humaner adulter Haut. Z Mikrosk Anat Forsch 104: 485–496

    PubMed  CAS  Google Scholar 

  • Wollina U, Henkel U, Schaarschmidt H, Knopf B (1991a) Histochemische Untersuchungen der Epidermisreaktion beim Dermatofibrom. Dermatol Monatsschr 177: 111–115

    Google Scholar 

  • Wollina U, Knopf B, Schaarschmidt H, Henkel U (1991b) Immunhistologische Lokalisation von Plasminogenaktivatoren in gesunder und pathologischer Epidermis. Dermatol Monatsschr 176: 11–16

    Google Scholar 

  • Wollina U, Schaarschmidt H, Berger U (1991c) Nävoide Bündelhaare Hautarzt 42: 189–191

    CAS  Google Scholar 

  • Wollina U, Wevers A, Mahrle G (1991d) Localization of calmodulin in epidermis and skin glands. A comparative investigation in different vertebrate species. Acta Histochem 90: 135–140

    Google Scholar 

  • Wollina U, Henkel U, Schaarschmidt H, Knopf B, Hipler C (1991e) Human eccrine sweat glands — a histochemical approach. Anat Anz 173: 155–159

    PubMed  CAS  Google Scholar 

  • Wollina U, Bonnekoh B, Klinger R, Wetzker R, Mahrle G (1992a) Vasoactive intestinal peptide ( VIP) acting as a growth factor for human keratinocytes. Neuroendocrinol Lett 14: 21–31

    Google Scholar 

  • Wollina U, Bonnekoh B, Mahrle G (1992b) Vasoactive intestinal peptide ( VIP) modulates the growth fraction of epithelial skin cells. Int J Oncol 1: 17–24

    Google Scholar 

  • Wyllie AH (1986) Commentary: what is apoptosis? Histopathology 10:995–998

    Article  PubMed  CAS  Google Scholar 

  • Wyllie AH (1988) Apoptosis. ISI Atlas Sci Immunol 1: 192–196

    Google Scholar 

  • Wyllie AH, Kerr JFR, Currie AR (1980) Cell death: the significance of apoptosis. Int Rev Cytol 68: 251–306

    Article  PubMed  CAS  Google Scholar 

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Dedicated to Prof. Dr. med Dr. h.c. G.K. Steigleder on the occasion of his birthday.

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Wollina, U. (1993). Diversity of Epithelial Skin Tumors: Thoughts and Comments on Some Basic Principles. In: Hecker, E., Jung, E.G., Marks, F., Tilgen, W. (eds) Skin Carcinogenesis in Man and in Experimental Models. Recent Results in Cancer Research, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84881-0_12

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