Abstract
The introduction of the alkylating agents was a milestone in the therapy and prolongation of the post-diagnosis survival of the patients with plasmocytoma. The survival rate has been expanded from 6–12 months (32, 57) to 30–36 months (29). Numerous other monoand polychemotherapy protocols failed to statistically significantly further prolong the survival rate (3, 9). The promising exceptionally beneficial results of some schemes could not, however, be adequately controlled. The analysis of the beneficial results and fiascos made the specialists first to look for a single (?) factor responsible for the prolongation of the survival rate and then to determine those clinical and laboratory tests, which can be applied for the evaluation of the tumour mass.
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References
Alexanian, R., Balberzak, S., Bonnet, J. D., Geham, E. A. Haut, A., Hewlett, J. S., Monto, R. W. Prognostic factors in multiple myeloma. Cancer. 36, 1192. 1975.
Alexanian, R. Localised and indolent myeloma. Blood. 56, 521. 1980.
Alexanian, R., Dreicer, R. Chemotherapy for multiple myeloma. Cancer. 55, 583. 1984.
Alexanian, R. Treatment of multiple myeloma. Acta Haematol. 63, 237. 1980.
Barlogie, B., Latrielle, J., Alexanian, R., Swartzengruber, D. E.,Smallwood, L., Maddox, A. M., Raker, M. N., Drewinko, B. Quantitative cytology in myeloma research. Clin. Haematol. 11, 19. 1982.
Bartl, R., Frisch, B., Burkhardt, R. Multiple myeloma. Bone Marrow Biopsies Revisited. Karger. Basel. 42. 1982.
Bartl, R., Frisch, B., Burkhardt, R., Fateh- Moghadam, A., Mahl, G., Gierster, P., Sund, M., Kettner, G. Bone marrow histology in myeloma: its importance in diagnosis, prognosis, classification and staging. Brit. J. Haematol. 51, 361. 1982.
Bataille, R., Durie, B. G. M., Grenier, J. Serum béta-2 microglobulin and survival duration in multiple myeloma: a simple reliable marker for staging. Brit. J. Haematol. 55, 439. 1983.
Bergsagel, D. E. Progress in the treatment of plasma cell myeloma. J. Clin. Oncol. 1,510. 1983.
Bergsagel, D. E. Prognostic factors in plasma cell myeloma. Eur. J. Canc. Clin. Oncol. 19, 1493. 1983.
Bettini, R., Steidl, L., Rapazzani, P., Giardina, G. Prognostic value of the staging system proposed by Merlini, Waldenström and Jayakar for multiple myeloma. Acta Haematol. 70, 378. 1983.
Blattner, W. A. Epidemiology of multiple myeloma and related plasma cell disorders: an analytic review. In: Progress in myeloma. Ed: by Potter, M. Elsevier North-Holland. N. Y. 1, 1980.
Boccadoro, M., Gavarotti, P., Fossati, L. Pileri, A., Marmont, F., Nerotto, G., Gallamino, A., Volta, C, Tribalto, M., Testa, M. G., Amadori, S., Mandelli, F., Durie, B.G.M. Low plasma cell 3(H) thymidine incorporation in monoclonal gammopathy of undetermined significance (MGUS), smouldering myeloma and remission phase myeloma: a relable indicator of patients not requiring therapy. Brit. J. Haematol. 58, 689. 1984.
Boga, Marianna, Jákó, J., Domán, J., Magyar, Éva, Konyár, E. Familial myeloma. Folia Haematol. 3, 201. 1973.
Bourguet, C. Claire, Grufferman, S., Delzell, Elizabeth, DeLong, R. Elizabeth, Cohen, H. J. Multiple myeloma and family history of cancer. Cancer. 56, 2133. 1985.
Buckman, R., Guzick, J., Galton, D. A. G. Long term survival in myelomatosis. Brit. J. Haematol. 52, 589. 1982.
Bunn, P. A., Krasnow, S., Makuch, R. W., Selam, M. L., Schechter, G. P. Flow cytometric analysis of DNA content of bone marrow cells in patients with plasma cell myeloma: clinical implications. Blood. 59, 528. 1982.
Burmeister, L. F., Burmeister G. D., Van Lier, S. F., Isacson, P. Selected cancer mortality and farm practices in Iowa. Amer. J. Epidemiol. 118, 72. 1983.
Cavo, V., Baccarani, M., Gobbi, A. Lipizer, A., Tura, S. Prognostic value of bone marrow plasma cell infiltration in stage I multiple myeloma. Brit. J. Haematol. 55, 683. 1983.
Cuzick, J. Radiation-induced myelomatosis. N. Engl. J. Med. 304, 204. 1981.
Cuzick, J., Velez, R., Doll, R. International variations and temporal trends in mortality from multiple myeloma. Internat. J. Cancer. 32, 13. 1983.
Decoufle, P., Stanislawczyk, K., Houten, L. A retrospective survey of cancer in relation to occupation. DHEW (NIOSH) Publication. 77, 1977.
Dorken, H., Vollmer, I. The epidemiology of multiple myeloma — investigation of 149 cases. Arch. Geschwulstforsch. 31, 18. 1968.
Drewinko, B., Alexanian, R., Boyer, H. The growth fraction of human myeloma cells. Blood. 57, 333. 1981.
Durie, B. G. M., Salmon, S. E. A clinical staging system for multiple myeloma. Cancer. 36, 842. 1975.
Durie, B. G. M., Salmon, S. E., Moon, T. E. Pretreatment tumour mass, cell kinetics and prognosis in multiple myeloma. Blood. 55, 364. 1980.
Durie, B. G. M., Salmon, S. E., Murdy, G. R. Relation of osteoclast growth: interrelationships between drug sensitivity, cell kinetics and activating factor production to extent of bone disease in multiple patient survival duration. Blood. 61,929. 1981.
Durie, B. G. M. Staging and kinetics of multiple myeloma. Clinics in Haematol. 11,3. 1982.
Durie, B. G. M., Salmon, S. E. The current status and future prospects of treatment for multiple myeloma. Clinics in Haematol. 11, 181. 1982.
Durie, B. G. M., Young, L. A., Salmon, S. E. Human myeloma in vitro colony myeloma.Brit. J. Haematol. 47, 21. 1983.
Endo, T., Okumura, H., Kikuchi, K., Munakata, J., Otake, M., Nomura, T., Asakawa, H. Immunoglobulin E (IgE) multiple myeloma. A case report and review of the literature. Amer. J. Med. 70, 1127. 1981.
Feinleib, M., MacMahon, B. Duration of survival in multiple myeloma. J. Nat. Cancer Inst. 24, 1259. 1960.
Fritz, E., Ludwig, H., Kundi, M. Prognostic relevance of cellular morphology in multiple myeloma. Blood. 63, 1072. 1984.
Gassmann, W., Pralle, H., Haferlach, T., Pandurevič, S., Graubner, M., Schmitz, N., Loffler, H. Staging system for multiple myeloma: a comparison. Brit. J. Haematol. 59, 703. 1968.
Grepp, P. R., Raymond, N. M., Kyle, R. A., O’Fallon, W. M. Multiple myeloma: significance of plasmablastic subtype in morphological classification. Blood. 63, 305. 1985.
Gramont, A., Benitez, O., Smadja, N., Brissand, P., Sirenelli, A., Hubert, D., Krulik, M., Debray, J. Bone marrow plasma cell infiltration in multiple myeloma. Brit. J. Haematol. 57, 351. 1984.
Hamburger, A. W., Salmon, S. E. Primary bioassay of human myeloma stem cells. J. Clin. Invest. 60, 846. 1977.
Hobbs, J. R. Growth rates and response to treatment in human myelomatosis. Brit. J. Haematol. 16, 607. 1969.
Hoffman, V., Salmon, S. E., Durie, B. G. M. Drug resistance in multiple myeloma associated with high in vitro incorporation of 3(H) thymidine. Blood. 58,471. 1981.
Ichimaru, M., Ishimaru, T., Mikami, M. Multiple myeloma among atomic bomb survivors in Hiroshima and Nagasaki by dose 1950–1976. Radiation Effects Research Report, Technical Report. 9. 1979.
Isomaki, H. A., Hakulinen, T.;Joutsenlahti, U. Excess risk of lymphoma, leukaemia and myeloma in patients with rheumatoid arthritis. J. Chronic. Dis. 31,691. 1978.
Jancelwiez, Z., Talatsuki, K., Sugai, S., Pruzanski, W. IgD multiple myeloma. Arch. Intern. Med. 135, 87. 1975.
Jákó, J., Virágh, Sz., Schopper, J., Sebők, J., Juhász, J. Nierenerkrankungen bei monoclonalen Gammopathien — eineklinisch-pathologische Studie. Immun. Infekt. 9,60. 1981.
Kyle, R. A. Multiple myeloma: a review of 869 cases. Mayo Clinic Proc. 50, 29. 1975.
Kyle, R. A.,Grepp, P. R. Smouldering multiple myeloma. N. Engl. J. Med. 302, 1374. 1980.
Kyle, R. A. Long term survival in multiple myeloma. N. Engl. J. Med. 308, 314. 1983.
Lee, B. J., Myers, J. Long term survival in myeloma. N. Engl. J. Med. 308, 243. 1983.
Liang, W., Hopper, J. E., Rowley, J. D. Karyotypic abnormalities and clinical aspects of patients with multiple myeloma and related paraproteinaemic diseases. Cancer. 44, 630. 1979.
Matzner, Y., Benbassat, J., Polliack, A. Prognostic factors in multiple myeloma. Acta Haematol. 60, 257. 1978.
Merlini, G., Waldenström, J. G., Jayakar, S. D. A new improved clinical staging system for multiple myeloma based on analysis of 123 treated patients. Blood. 55, 1011, 1980.
Milham,S. Leukemia and multiple myeloma in farmers. Amer. J. Epidemiol. 94, 307. 1971.
Milham, S. Occupational mortality in Washington State, 1950–1971. DHEW (NIOSH) Publication 76, 1976.
MRC Working Party on Leukaemia in Adults. Report on the first myelomatosis trial. part 1. Analysis of presenting features of prognostic importance. Brit. J. Haematol. 24, 123. 1973.
MRC Working Party of Leukaemia in Adults. Prognostic features in the third myelomatosis trial. Brit. J.Cancer. 42, 831. 1980.
Nathans, D., Fahey, J. L., Potter, M. The formation of myeloma protein by a mouse plasma cell tumour. J. Exp. Med. 108, 121. 1958.
Norfolk, D., Child, J. A., Cooper, E. H., Kerruish, S., Milford Ward, A. Serum beta-2 microglobulin in myelomatosis; potential value in stratification and monitoring. Brit. J. Cancer. 42,510. 1980.
Osgood, E. E. The survival time of patients with plasmacytic myeloma. Cancer Chemotherapy Reports. 9, 1. 1960.
Osmond, C, Gardner, M. J. Age, period and cohort models applied to cancer mortality rates. Statistical Medicine. 1, 245. 1982.
Otieno, L. S., Ogada, T. Multiple myeloma at Kenyatta National Hospital, 1973–1976. East African Med. J. 54, 574. 1977.
Salmon, S. E., Smith, B. A. Immunoglobulin synthesis and total body tumour cell number in IgG multiple myeloma. J. Clin. Invest. 49, 1114. 1970.
Salmon, S. E., Hamburger, A. W., Soehnlen, B. J., Durie, B. G. M., Alberts, D. S., Moon, T. E. Quantitation of differential sensitivity of human tumour stem cells to anticancer drugs. N. Engl. J. Med. 298, 1321. 1978.
Salmon, S. E. Cloning and chemosensitivity of myeloma stem cells. Clin. Haematol. 11, 47. 1982.
Scarffe, H., Anderson, H., Palmer, M. K., Crowther, D. Prognostic significance of pretreatment serum beta-2 microglobulin levels in multiple myeloma. Eur. J. Cancer Clin. Oncol. 19, 1361. 1983.
Schur, P. H., Kyle, R. A., Block, K. J., Hammack, W. J., Rivers, S. L., Sargent, A., Ritchie, R. F., McIntyre, O. R., Moloney, W. C, Wolfson, L. IgG subclasses: relationship to clinical aspects of multiple myeloma and frequency distribution among M-components. Scand. J. Haematol. 12, 60. 1974.
Skipper, H. E. Thoughts on cancer chemotherapy and combination modality therapy. J. Amer. Med. Ass. 230, 1033. 1974.
Sullivan, P. W., Salmon, S. E. Kinetics of tumours growth and regression in IgG multiple myeloma. J.Clin. Invest. 51,1697. 1972
Velez, R., Beral, V., Cuzick, J. Increasing trends of multiple myeloma mortality in England and Wales; 1950–79; are the changes real? J. Nat. Cancer Inst. 69, 387. 1982.
Waldbaum, B., Gelfand, M. Myelomatosis in the Rhodesian African. Tropical Geographical Med. 26, 26. 1974.
Waterhouse, J. Muir, C, Shanmugaratnam, K., Powell, J. Cancer incidence in five continents, vol IV. IARC publication No 42. Lyon. 1982.
Woodruff, R. K., Wodsworth, J., Malpass, J. S., Tobias, J. S. Clinical staging of multiple myeloma. Brit. 7. Haematol. 42. 199. 1979.
Wurster-Hill, D. H., Mclntyre, O. R., Cornwell, G. G. Chromosome studies in myeloma. Virch. Arch. ’B Cell Path. 29, 93. 1978.
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© 1991 Jákó János, Budapest
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Jákó, J. (1991). Prognosis and epidemiology of plasmocytomas. In: Gammopathy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84929-9_9
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