Abstract
The medical treatment of epilepsy has been significantly improved by adjusting the dose of anti-epileptic drugs to the therapeutic range of serum levels (Buchthal et al., 1960, 1968; Lund et al., 1971; Penry et al., 1972). For carbamazepine, however, the therapeutic range in serum has not yet been established although different methods for determination of the drug have been available (Führ, 1964; Scheiffarth et al., 1966; Larsen et al., 1969; Nielsen and Remmer, 1969; Christiansen, 1971 a; Kupferberg, 1972). Furthermore, little is known about the pharmacokinetics of this drug in man (Winter Research Laboratories, 1968; Meinardi, 1972; Cereghino et al., 1973), especially the relation between serum and cerebrospinal fluid concentrations (Johannessen and Strandjord, 1971; Meinardi, 1972; Johannessen and Strandjord, 1973).
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References
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Strandjord, R.E., Johannessen, S.I. (1975). A Preliminary Study of Serum Carbamazepine Levels in Healthy Subjects and in Patients with Epilepsy. In: Schneider, H., Janz, D., Gardner-Thorpe, C., Meinardi, H., Sherwin, A.L. (eds) Clinical Pharmacology of Anti-Epileptic Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85921-2_17
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DOI: https://doi.org/10.1007/978-3-642-85921-2_17
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