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Regulatory Factors in the Immune Response: Analysis and Perspective

  • Conference paper
Cyclic AMP, Cell Growth, and the Immune Response

Abstract

Cellular immunology has made rapid advances in elucidating, on a broad scale, the nature of cells involved in immune responses and the diversity of their functions and products, with appropriate recent emphasis on the differences between cell-mediated responses and humoral antibody formation (1). We have learned much in recent years about the usual need for cell cooperation in the activation of antibody-forming cells (2–6), the synthesis and nature of products that can be released from such cells (7–9), and we have begun to learn something about the nature of mediators of cell-mediated immune responses (10,– 11). We also have become increasingly aware of the importance of genetic and physiological factors that can influence the magnitude of immune responses (12,13). Yet, until recently there remained a paucity of information regarding the nature of molecular events that are responsible for the activation of immunocompetent cells and for the regulation of the magnitude of their response. While adjuvant effects and tolerogenic effects have been familiar and widely investigated phenomena for a long time and are known to involve the same cells (14), we have only just begun to understand some of the molecular events and cellular factors that appear to be critically involved in regulating the intensity of immune responses in general, and the functions of specific cell populations in particular (e. g., those responsible for antibody formation versus those involved in cell-mediated immunity).

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  1. Werner Braun
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Editors and Affiliations

  1. Department of Medicine, The Johns Hopkins University School of Medicine at The Good Samaritan Hospital, Baltimore, Maryland, 21239, USA

    Lawrence M. Lichtenstein

  2. Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Charles W. Parker

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Braun, W. (1974). Regulatory Factors in the Immune Response: Analysis and Perspective. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (eds) Cyclic AMP, Cell Growth, and the Immune Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86026-3_2

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