Abstract
Untill 1955, surgical removal of the pancreas or selective destruction of the beta-cells by alloxan injection were the commonest methods for producing an insulin deficient state. These procedures were open to criticism for numerous reasons: severe lesions induced in other organs, delayed appearance of the diabetic state, irreversibility of this condition. In fact those procedures studied far more the secondary injuries to the enzyme machinery of the tissues than the direct effects of the insulin deficiency.
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References
Altzuler, N., R. Steel, J. Tobin, I. Rathgeb, and R. C. De Bodo: Effect of anti-insulin serum on glucose production and uptake in dogs. In Excerpta Medica International Congress Series No 74, Abstract No 333, p. 168, 1964.
Anderson, J. W., K. G. Kilbourn, J. Robinson, and P. H. Wright: Diabetic acidosis in rats treated with anti-insulin serum, Clin. Sci. 24, 417 (1963).
Armin, J., N. F. Cunningham, R. T. Grant, M. K. Lloyd, and P. H. Wright: Acute insulin deficiency provoked in the dog, pig and sheep by single injections of anti-insulin serum. J. Physiol. (Lond.) 157, 64 (1961).
Armin, J., R. T. Grant, and P. H. Wright: Acute insulin deficiency provoked by single injections of anti-insulin serum. J. Physiol. (Lond.) 153, 131 (1960).
Conard, V., Y. Arnould, W. Malaisse, and J. R. M. Franckson: Influence d’une carence aiguë en insuline sur le débit glucosé hépatique du chien normal. Arch. int. Pharmacodyn. 144, 585 (1963).
Cunningham, N. F., D. S. P. Patterson, and P. H. Wright: Acute insulin deficiency provoked in sheep and cows by single injections of anti-insulin serum. J. Physiol. (Lond.) 169, 137 (1963).
Franckson, J. R. M., Y. Arnould, W. Malaisse, and V. Conard: Glucose metabolism in the normal anaesthetised dog injected successively with anti-insulin serum and insulin. Diabetes 13, 532 (1964).
Gregor, W. H., J. M. Martin, J. R. Williamson, P. E. Lacy, and D. M. Kepnis: A study of the diabetic syndrome produced in rats by anti-insulin serum. Diabetes 12, 73 (1963).
Kitigawa, M., K. Onoue, Y. Okamura, M. Anai, and Y. Yamamura: Immunochemical studies of insulin. II. The specificity of insulin-neutralising antibody and experimental diabetes. J. Biochem. (Tokyo) 48, 483 (1960).
Lacy, P. E., and P. H. Wright: Allergic interstitial pancreatitis in rats injected with Guineapig anti-insulin serum. Diabetes 14, 634 (1965).
Malaisse, W., H. Cleempoel, V. Conard et J. R. M. Franckson: Modifications hydrodynamiques secondairesàdes perfusions glucosées de longue durée chez le chien normal. Mal. cardiovasc. 3, 383 (1962).
V. Conard et J. R. M. Franckson —, J. R. M. Franckson et V. Conard: Troubles électrolytiques secondairesàune perfusion glucosée de longue durée. Arch, intern. Physiol. 71, 64 (1963).
—, F. Malaisse-Lagae et P. H. Wright. In preparation (1966)
Moloney, P. J., and M. Coval: Antigenecity of insulin; diabetes induced by specific antibodies, Biochem. J. 59, 179 (1955).
—, and L. Goldsmith: On the antigenicity of insulin. Canad. J. Biochem. 35, 79 (1957).
Ooms, H. A., J. Litvine, Y. Arnould, W. Malaisse, and J. R. M. Franckson: 1966. In preparation.
Robinson, B. H. B., and P. H. Wright: Guinea-pig anti-insulin serum. J. Physiol. (Lond.) 155, 302 (1961).
Scow, R. O.: „Total“ pancreatectomy in the rat; operation, effects and postoperative care. Endocrinology 60, 359 (1957).
Stern, M., S. R. Wagle, M. J. Sweeney, and J. Ashmore: Studies in experimental diabetes. 1. Effects of anti-insulin serum on C14-glucose metabolism. J. biol. Chem. 238, 12 (1963).
Tarrant, M. E., R. H. Mahler, and J. Ashmore: Studies in experimental diabetes. IV. Free fatty acid metabolism. J. biol. Chem. 239, 1714 (1964).
J. Ashmore —, R. H. S. Thompson, and P. H. Wright: Some aspects of lipid metabolism in rats treated with anti-insulin serum. Biochem. J. 84, 6 (1962).
Wagle, S. R.: Studies on mechanism of glucose synthesis in normal and diabetic rats. Diabetes 15, 19 (1966).
—, and J. Ashmore: Studies in experimental diabetes. II. Carbon dioxide fixation. J. biol. Chem. 238, 17 (1963).
Wright, P. H.: Hormone antibodies in Endocrinology, Vitamins and Hormones. 1966. In press.
— Experimental insulin deficiency due to insulin antibodies. In press.
—, and L. R. Calimlim: The assay of insulin antibodies produced by the Guinea-pig. Nature (Lond.) 207, 995 (1965).
—, R. A. Kreisberg, B. Halpern, and R. E. Dolkart: Properties of insulin antibodies produced by the guinea-pig, horse, sheep and man. Diabetes 11, 519 (1962).
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Franckson, J.R.M., Malaisse, W. (1967). Diabetes Induced in Experimental animals by Insulin antibodies. In: Klein, E. (eds) Die Pathogenese des Diabetes Mellitus. Symposion der Deutschen Gesellschaft für Endokrinologie, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86329-5_8
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DOI: https://doi.org/10.1007/978-3-642-86329-5_8
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