Summary
The main components of water soluble metabolites prepared by incubation of oestradiol- -17β with rat liver homogenates, NADPH and oxygen were shown to be S-(2,3,17β-trihydroxy-1,3,5(10)-oestratrien-1-yl)-glutathione and S-(2,3,17β-trihydroxy-1,3,5(10)-oestratrien-4-yl)-glutathione. The structures were proven by comparison with synthetic substances, the 1-H-and the 4-H-isomeres of which were differenciated by nmr spectra.
The activity of the liver homogenates in transforming oestradiol-17β to glutathione conjugates was increased by application of phenobarbital to femal rats. The biological significance of the glutathione conjugates of 2,3-dihydroxy-oestratriens is discussed.
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© 1969 Springer-Verlag Berlin · Heidelberg
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Kuss, E. (1969). Neue Metabolite des Oestradiols-17β . In: Kracht, J. (eds) Oestrogene Hypophysentumoren. Oestrogene Hypophysentumoren, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95126-8_32
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DOI: https://doi.org/10.1007/978-3-642-95126-8_32
Publisher Name: Springer, Berlin, Heidelberg
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