Skip to main content
SpringerLink
Log in

Melanozytäre Nävi und malignes Melanom

  • Chapter
Histopathologie der Haut

Zusammenfassung

Melanozytäre Nävi werden als gutartige Proliferationen der Melanozyten definiert. Sie können in der Epidermis lokalisiert sein (junktionaler melanozytärer Nävus) oder in der Dermis (intradermaler melanozytärer Nävus) oder sowohl in der Epidermis wie auch in der Dermis vorkommen (Cornpound-Nävus). Melanozytäre Nävi sind bei weitem die häufigsten Tumoren der Haut in der weißen Bevölkerung; sie kommen in der Regel multipel vor.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Cramer SF (1991) The origin of epidermal melanocytes. Implications for the histogenesis of nevi and melanomas. Arch Pathol Lab Med 115: 115–119

    PubMed  CAS  Google Scholar 

  • Garbe C (1997) Melanozytäre Nävi und Melanomrisiko. In: Garbe C, Dummer R, Kaufmann R, Tilgen W (Hrsg) Dermatologische Onkologie. Springer, Berlin Heidelberg New York Tokyo, S 215–230

    Book  Google Scholar 

  • Kerl H (2001) Diagnose und Therapie dysplastischer melanozytärer Nävi: Schluss der Debatte. In: Plewig G, Degitz K (Hrsg) Fortschritte der praktischen Dermatologie und Venerologie. Springer, Berlin Heidelberg New York Tokyo, S 80–84

    Google Scholar 

  • Ackerman AB, Cerroni L, Kerl H (1994) Pitfalls in histopathologic diagnosis of malignant melanoma. Lea und Febiger, Philadelphia

    Google Scholar 

  • Barnhill RL, Fleischli M (1995) Histologic features of congenital melanocytic nevi in infants 1 year of age or younger. J Am Acad Dermatol 33: 78o-785

    Google Scholar 

  • Helmbold P, Rompel R, Petres J, Lübbe D, Marsch WC (1999) Kongenitale melanozytäre Nävi. Hautarzt 5o: 779–784

    Article  Google Scholar 

  • Mark GJ, Mihm MC, Liteplo MG, Reed RJ, Clark WH (1973) Congenital melanocytic nevi of the small and garment type. Clinical, histologic, and ultrastructural studies. Hum Pathol 4: 395–418

    Article  PubMed  CAS  Google Scholar 

  • Massi D, Carli P, Franchi A, Santucci M (1999) Nävus-associated melanomas: Cause or chance? Melanoma Res 9: 85–91

    Article  PubMed  CAS  Google Scholar 

  • Rhodes AR, Silverman RA, Harrist TJ, Melski JW (1985) A histologic comparison of congenital and acquired nevomelanocytic nevi. Arch Dermato1121: 1266–1273

    Google Scholar 

  • Stenn KS, Arons M, Hurwitz S (1983) Patterns of congenital nevocellular nevi. A histologic study of thirty-eight cases. J Am Acad Dermatol 9: 388–393

    Article  PubMed  CAS  Google Scholar 

  • Ackerman AB, Magana-Garcia M (199o) Naming acquired melanocytic nevi - Unna’s, Miescher’s, Spitz’s, Clark’s. Am J Dermatopathol 12: 193–209

    Google Scholar 

  • Clemmensen OJ, Kroon S (1988) The histology of „congenital features“ in early acquired melanocytic nevi. J Am Acad Dermatol 19: 742–746

    Article  PubMed  CAS  Google Scholar 

  • Ackerman AB, Cerroni L, Kerl H (1994) Pitfalls in histopathologic diagnosis of malignant melanoma. Lea und Febiger, Philadelphia

    Google Scholar 

  • Kamino H, Tam ST (199o) Compound blue nevus: A variant of blue nevus with an additional junctional dendritic component. A clinical, histopathologic, and imunohistochemical study of six cases. Arch Dermato1126:1330–1333

    Google Scholar 

  • Pulitzer DR, Martin PC, Cohen AP, Reed RJ (1991) Histologic classification of the combined nevus. Analysis of the variable expression of melanocytic nevi. Am J Surg Pathol 15: 1111–1122

    Article  PubMed  CAS  Google Scholar 

  • Barnhill RL, Argenyi ZB, From L et al. (1999) Atypical Spitz nevi/tumors: Lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol 30: 513–520

    Article  PubMed  CAS  Google Scholar 

  • Barnhill RL, Barnhill MA, Berwick M, Mihm MC Jr (1991) The histologic spectrum of pigmented spindle cell nevus: A review of 120 cases with emphasis on atypical variants. Hum Pathol 22: 52–58

    Article  PubMed  CAS  Google Scholar 

  • Burg G, Kempf W, Hchli M, Huwyler T, Panizzon RG (1998) Tubular“ epithelioid cell nevus: A new variant of Spitz’s nevus. J Cutan Pathol 25: 475–478

    Google Scholar 

  • Harvell JD, Meehan SA, LeBoit PE (1997) Spitz’s nevi with halo reaction: A histopathologic study of 17 cases. J Cutan Pathol 24: 611–619

    Article  PubMed  CAS  Google Scholar 

  • Paniago-Pereira C, Maize JC, Ackerman AB (1978) Nevus of large spindle and/or epithelioid cells (Spitz’s nevus). Arch Dermatol 114: 1811–1823

    Article  PubMed  CAS  Google Scholar 

  • Rogers GS,Advani H, Ackerman AB (1985) A combined variant of Spitz’s nevi. How to differentiate them from malignant melanomas. Am J Dermatopathol (Suppl) 7: 61–78

    Article  Google Scholar 

  • Smith KJ, Barrett TL, Skelton III HG, Lupton GP, Graham JH (1989) Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus). Am J Surg Pathol 13: 931–939

    Article  PubMed  CAS  Google Scholar 

  • Smith NP (1987) The pigmented spindle cell tumor of Reed: An underdiagnosed lesion. Semin Diagn Pathol 4: 75–87

    PubMed  CAS  Google Scholar 

  • Spatz A, Peterse S, Fletcher CDM, Barnhill RL (1999) Plexiform Spitz nevus. An intradermal Spitz nevus with plexiform growth pattern. Am J Dermatopathol 21: 542–546

    Article  PubMed  CAS  Google Scholar 

  • Walsh N, Crotty K, Palmer A, McCarthy S (1998) Spitz nevus versus spitzoid malignant melanoma: An evaluation of the current distinguishing histopathologic criteria. Hum Pathol 29: uo5–1112

    Google Scholar 

  • Ackerman AB, Massi D, Nielsen TA (1999) Dysplastic nevus - Atypical mole or typical myth? Ardor Scribendi, Philadelphia

    Google Scholar 

  • Clark WH Jr, Tucker MA (1998) Problems with lesions related to the development of malignant melanoma: Common nevi, dysplastic nevi, malignant melanoma in situ, and radial growth phase malignant melanoma. Hum Pathol 29: 8–14

    Article  PubMed  Google Scholar 

  • Clark WH Jr, Elder DE, Guerry IV D, Epstein MN, Greene MH, Van Horn M (1984) A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 15: 1147–1165

    Article  PubMed  Google Scholar 

  • Clark WH Jr, Reimer RR, Greene M, Ainsworth AM, Mastrangelo MJ (1978) Origin of familial malignant melanomas from heritable melanocytic lesions–„The BK mole syndrome“. Arch Dermatol 114: 732–738

    Article  PubMed  Google Scholar 

  • Elder DE, Murphy GF (1991) Atlas of tumor pathology - Melanocytic tumors of the skin. Armed Forces Institute of Pathology, Washington/DC

    Google Scholar 

  • Kerl H, Soyer HP, Hdl S, Smolle J (199o) Diagnostik dys plastischer Nvi. Dtsch Med Wochenschr 115: 1104–1107

    Google Scholar 

  • Murphy GF, Mihm Jr MC (1999) Recognition and evaluation of cytological dysplasia in acquired melanocytic nevi. Hum Pathol 3o: 506–512

    Article  Google Scholar 

  • NIH Consensus Development Panel on Early Melanoma (1992) NIH Consensus Conference–Diagnosis and treatment of early melanoma. JAMA268: 1314–1319

    Google Scholar 

  • Dummer R, Kempf W, Burg G (1998) Pseudo-melanoma after laser therapy. Dermatology 197: 71–73

    Article  PubMed  CAS  Google Scholar 

  • Kornberg R, Ackerman AB (1975) Pseudomelanoma. Recurrent melanocytic nevus following partial surgical removal. Arch Dermatol 111: 1588–1590

    Article  PubMed  CAS  Google Scholar 

  • Kerl H, Trau H, Ackerman AB (1984) Differentiation of melanocytic nevi from malignant melanomas in palms, soles, and nail beds solely by signs in the cornified layer of the epidermis. Am J Dermatopathol 6 (Supp11): 159–161

    PubMed  Google Scholar 

  • Signoretti S, Annessi G, Puddu P, Faraggiana T (1999) Melanocytic nevi of palms and soles.A histological study according to the plane of section. Am J Surg Pathol 23: 283–287

    Article  PubMed  CAS  Google Scholar 

  • Christensen WN, Friedman KJ, Woodruff JD, Hood AF (1987) Histologic characteristics of vulvar nevocellular nevi. J Cutan Pathol 14: 87–91

    Article  PubMed  CAS  Google Scholar 

  • Clark WH Jr, Hood AF, Tucker MA, Jampel RM (1998) Atypical melanocytic nevi of the genital type with a discussion of reciprocal parenchymal-stromal interactions in the biology of neoplasia. Hum Pathol 29 (Suppl 1): 1–24

    Article  Google Scholar 

  • Rongioletti F, Ball RA, Marcus R, Barnhill RL (2000) Histopathological features of flexural melanocytic nevi: a study of 4o cases. J Cutan Pathol 27: 215–217

    Article  PubMed  CAS  Google Scholar 

  • Elder DE, Murphy GF (1991) Atlas of tumor pathology - Melanocytic tumors of the skin. Armed Forces Institute of Pathology, Washington/DC

    Google Scholar 

  • Tran TA, Carlson JA, Basaca PC, Mihm MC (1998) Cellular blue nevus with atypia (atypical cellular blue nevus): A clinicopathologic study of nine cases. J Cutan Pathol 25: 252–258

    Article  PubMed  CAS  Google Scholar 

  • Barnhill RL, Mihm Jr MC, Magro CM (1991) Plexiform spindle cell naevus: A distinctive variant of plexiform melanocytic naevus. Histopathology 18: 243–247

    Article  PubMed  CAS  Google Scholar 

  • Cooper PH (1992) Deep penetrating (plexiform spindle cell) nevus–A frequent participant in combined nevus. J Cutan Pathol 19: 172–180

    Article  PubMed  CAS  Google Scholar 

  • Seab JA Jr, Graham JH, Helwig EB (1989) Deep penetrating nevus. Am J Surg Pathol 13: 39–44

    Article  PubMed  Google Scholar 

  • Bolognia JL (1992) Reticulated black solar lentigo (ink spot lentigo). Arch Dermatol 128: 934–94o

    Google Scholar 

  • Cohen LM, Bennion SC, Johnson TW, Golitz LE (1997) Hypermelanotic nevus: Clinical, histopathologic, and ultra-structural features in 316 cases. Am J Dermatopathol 19: 23–30

    Article  PubMed  CAS  Google Scholar 

  • Gartmann H (1978) Zur Dignität der naevoiden Lentigo. Ein Beitrag zur Früherkennung und -erfassung des malignen Melanoms und seiner Vorstufen. Z Hautkr 53: 91–100

    PubMed  CAS  Google Scholar 

  • Kaddu S, Soyer HP, Wolf IH, Rieger E, Kerl H (1997) Retikuläre Lentigo. Hautarzt 48: 181–185

    Article  PubMed  CAS  Google Scholar 

  • Okamura, JM, Barr RJ, Cantos KA (2000) Benign atypical junctional melanocytic hyperplasia associated with intradermal nevi: A common finding that may be confused with melanoma in situ. Mod Pathol 13: 857–860

    Article  PubMed  CAS  Google Scholar 

  • Pennoyer JW, Grin CM, Driscoll MS, Dry SM, Walsh SJ, Gelineau JP, Grant-Kels JM (1997) Changes in size of melanocytic nevi during pregnancy. J Am Acad Dermatol 36: 378–382

    Article  PubMed  CAS  Google Scholar 

  • Tronnier M, Alexander M, Neitmann M, Brinckmann J, Wolff HH (woo) Morphologische Vernderungen in melanozytren Nvi durch exogene Faktoren. Hautarzt 51: 561–566

    Google Scholar 

  • Weyers W, Bonczkowitz M, Weyers I, Bittinger A, Schill W-B (1996) Melanoma in situ versus melanocytic hyperplasia in sun-damaged skin. Assessment of the significance of histopathologic criteria for differential diagnosis. Am J Dermatopathol 18: 560–566

    Article  PubMed  CAS  Google Scholar 

  • Ackerman AB, Cerroni L, Kerl H (1994) Pitfalls in histopathologic diagnosis of malignant melanoma. Lea und Febiger, Philadelphia

    Google Scholar 

  • Balch CM, Buzaid AC, Soong S-J et al. (2001) Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 19: 3635–3648

    PubMed  CAS  Google Scholar 

  • Büttner P, Garbe C, Bertz J et al. (1995) Primary cutaneous melanoma. Optimized cutoff points of tumor thickness and importance of Clark’s level for prognostic classification. Cancer 75: 2499–2506

    Article  PubMed  Google Scholar 

  • Clark WH Jr, From L, Bernardino EA, Mihm MC (1969) The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res 29: 705–726

    PubMed  Google Scholar 

  • Clemente C, Cook M, Ruiter D, Mihm C, Histopathologic diagnosis of melanoma. WHO Melanoma Programme Publications No. 5

    Google Scholar 

  • Cochran AJ, Bailly C, Cook M, Crotty K, Mihm M, Mooi W, Sagebiel R (1997) Recommendations for the reporting of tissues removed as part of the surgical treatment of cutaneous melanoma. Hum Pathol 28: 1123–1125

    Article  PubMed  CAS  Google Scholar 

  • Kerl H, Hödl S, Kresbach H, Stettner H (1982) Diagnosis and prognosis of the early stages of cutaneous malignant melanoma. Clin Oncol 1: 433–453

    Google Scholar 

  • Kerl H, Hödl S, Stettner H (1981) Acral lentiginous melanoma. In: Ackerman AB (ed) Pathology of malignant melanoma. Masson, New York, pp 217–242

    Google Scholar 

  • Scalzo DA, Hida CA, Toth G, Sober AJ, Mihm MC Jr (1997) Childhood melanoma: A clinicopathological study of 22 cases. Melanoma Res 7: 63–68

    Article  PubMed  CAS  Google Scholar 

  • Tronnier M, Garbe C, Bröcker E-B, Stadler R, Steinkraus V, Soyer HP, Wolff HH (1997) Standards der histopathologischen Diagnose maligner Melanome. Empfehlungen der Arbeitsgruppe des Zentralregisters Malignes Melanom der Deutschen Dermatologischen Gesellschaft. Hautarzt 48: 720–729

    Article  PubMed  CAS  Google Scholar 

  • Weyers W, Euler M, Diaz-Cascajo C, Schill W-B, Bonczkowitz M (1999) Classification of cutaneous malignant melanoma. A reassessment of histopathologic criteria for the distinction of different types. Cancer 86: 288–299

    Article  PubMed  CAS  Google Scholar 

  • Crowson AN, Magro CM, Mihm Jr MC (1999) Malignant melanoma with prominent pigment synthesis: „animal type“ melanoma–A clinical and histological study of six cases with a consideration of other melanocytic neoplasms with prominent pigment synthesis. Hum Pathol 30: 543–550

    Article  PubMed  CAS  Google Scholar 

  • Hashiro M, Miyamoto T, Sonoda S, Okumura M (1998) Malignant melanoma developing from an intradermal nevus. Dermatology 196: 425–426

    Article  PubMed  CAS  Google Scholar 

  • Hitchcock MG, McCalmont TH, White WL (1999) Cutaneous melanoma with myxoid features. Twelve cases with differential diagnosis. Am J Surg Pathol 23: 1506–1513

    Article  PubMed  CAS  Google Scholar 

  • Kao GF, Helwig EB, Graham JH (1992) Balloon cell malignant melanoma of the skin. Cancer 69: 2942–2952

    Article  PubMed  CAS  Google Scholar 

  • Koch H, Zelger B. Cerroni L, Soyer HP, Kerl H (1996) Malignant blue nevus: Malignant melanoma in association with blue nevus. Eur J Dermatol 6: 335–338

    Google Scholar 

  • Kossard S, Wilkinson B (1997) Small cell (naevoid) melanoma: A clinicopathologic study of 131 cases. Austral J Dermatol 38 (Suppl): 54–58

    Google Scholar 

  • LiVolsi VA, Brooks JJ, Soslow R, Johnson BL, Elder DE (1992) Signet cell melanocytic lesions. Mod Pathol 5: 515–520

    PubMed  CAS  Google Scholar 

  • Lucas DR, Tazelaar HD, Unni KK, Wold LE, Okada K, Dimarzio Jr DJ, Rolfe B (1993) Osteogenic melanoma. A rare variant of malignant melanoma. Am J Surg Pathol 17: 400–409

    Article  PubMed  CAS  Google Scholar 

  • Megahed M, Hofmann U, Flür M, Hölzle E (1993) Das polypoide maligne Melanom. Hautarzt 44: 437–439

    PubMed  CAS  Google Scholar 

  • Reed RJ (1999) Dimensionalities: Borderline and intermedi ate melanocytic neoplasia. Hum Pathol 30: 521–524

    Article  PubMed  CAS  Google Scholar 

  • Reed RJ, Webb SV, Clark WH Jr (1990) Minimal deviation melanoma (Halo nevus variant). Am J Surg Pathol 14: 53–68

    Article  PubMed  CAS  Google Scholar 

  • Bütten A, Hügel H, Kutzner H, Schirren CG, Küchler A, Groth W (1996) Das desmoplastische maligne Melanom. Hautarzt 47: 447–453

    Article  Google Scholar 

  • McNutt NS (1998) Triggered trap“: Nevoid malignant melanoma. Semin Diagn Pathol 15: 203–209

    Google Scholar 

  • Schmoeckel C, Castro CE, Braun-Falco 0 (1985) Nevoid malignant melanoma. Arch Dermatol Res 277: 362–369

    Article  PubMed  CAS  Google Scholar 

  • Wong T-Y, Duncan LM, Mihm MC Jr (1993) Melanoma mimicking dermal and Spitz’s nevus („nevoid” melanoma). Semin Surg Oncol 9: 188–193

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. C. Garbe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Cerroni
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Kerl
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universitätsklinik für Dermatologie und Venerologie, Karl-Franzens-Universität Graz, Auenbruggerplatz 8, A-8036, Graz, Österreich

    Helmut Kerl  & Lorenzo Cerroni  & 

  2. Universitäts-Hautklinik, Eberhard-Karls-Universität Tübingen, Liebermeisterstraße 25, D-72076, Tübingen, Deutschland

    Claus Garbe

  3. Klinik für Dermatologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, D-23562, Lübeck, Deutschland

    Helmut H. Wolff

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Garbe, C., Cerroni, L., Kerl, H. (2003). Melanozytäre Nävi und malignes Melanom. In: Kerl, H., Garbe, C., Cerroni, L., Wolff, H.H. (eds) Histopathologie der Haut. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07784-9_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-07784-9_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07785-6

  • Online ISBN: 978-3-662-07784-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation