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The Regulation of eIF4F During Cell Growth and Cell Death

  • Chapter
Signaling Pathways for Translation

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 27))

Abstract

Much effort has been focused on questions concerning the highly regulated processes of cell growth, proliferation and programmed cell death (apoptosis). Hormones, growth factors and ligands exert pleiotypic effects through activation of specific cell-surface receptors, and via transmembrane signalling and activation of common protein kinase/phosphatase cascades inside the cell. These, in turn, trigger an array of cellular responses, culminating in either cell growth and division, differentiation or cell death. One of the obligatory, early responses in all of these processes is a modulation of the rate of protein synthesis, mediated by regulating the phosphorylation of translation initiation factor polypeptides and their association into functional complexes. This chapter will review current knowledge about the regulation of these initiation factor proteins in response to cell growth and cell death.

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  1. Biochemistry Laboratory, School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK

    Simon J. Morley

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  1. Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA

    Robert E. Rhoads

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Morley, S.J. (2001). The Regulation of eIF4F During Cell Growth and Cell Death. In: Rhoads, R.E. (eds) Signaling Pathways for Translation. Progress in Molecular and Subcellular Biology, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09889-9_1

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  • Print ISBN: 978-3-642-07505-6

  • Online ISBN: 978-3-662-09889-9

  • eBook Packages: Springer Book Archive

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