Abstract
The complexity of the effects of histamine upon the circulatory apparatus might explain what was called, in earlier times, the “histamine paradox”. When injected intravenously in cats and dogs, histamine produced a sharp fall in arterial blood pressure, though when perfused through isolated tissues or organs, not infrequently, a pure vaso-constrictor effect with decline in outflow was observed. This constrictor effect upon isolated perfused organs was particularly seen in cats (Dale and Richards, 1918). With improvement in the conditions of the perfusion experiments, and especially when dogs or monkeys were utilized as donors of the biological structure to be perfused, a vasodilation with increase in volume of the perfused limb and its venous outflow was observed (Burn and Dale, 1926). However, in rabbits and rats the main effect of histamine, when injected into the perfusing cannula, was a sharp decrease in outflow, in spite of the fact that when the amine was injected intravenously in the intact rat, a consistent fall in blood pressure could be observed. Even in the rabbit, under special conditions of anesthesia, histamine produced a fall of arterial blood pressure (Feldberg, 1927). Therefore, the paradox persists and can be understood only through an extensive analysis of the mode of action of histamine upon the cardio-vascular system.
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Rocha e Silva, M. (1966). Action of Histamine upon the Circulatory Apparatus. In: Rocha e Silva, M. (eds) Histamine and Anti-Histaminics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 18 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12016-3_12
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