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Disordered Apoptosis as a Mechanism for Adverse Outcome

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1997

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1997))

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Abstract

The clinical syndrome referred to as “systemic inflammatory response” (SIRS) has long been recognized as a cascade of pro-inflammatory mediator activities that overcome compensatory anti-inflammatory activities. Moreover, the excessive activity of several immune cell mediators (cytokines), such as tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1), are believed to be responsible for the hemodynamic instability and manifestations of organ failure in critically ill patients [1, 2]. However, several clinical trials utilizing agents directed against these cytokines have demonstrated limited efficacy, with no significant reduction in the incidence of endorgan failure or mortality [3]. These clinical failures have prompted a reappraisal of the influences of pro-inflammatory mediators and the complexities of their contribution to the inflammatory process. Paramount to these efforts are investigations at the cellular level particularly as they pertain to receptor-signaling, functional integrity of immune cells during systemic insults (i.e. infectious, traumatic, thermal), and the mechanisms for homeostatic regulation of dysfunctional immunocytes.

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References

  1. Van der Poll T, Lowry SF (1995) Endogenous mechanisms regulating TNF and IL-1 during sepsis. In: Vincent JL (ed) Yearbook of Intensive Care and Emergency Medicine 1995, pp 385–397

    Chapter  Google Scholar 

  2. Guirao X, Lowry SF (1996) The biologic control of injury and inflammation: Much more than too little or too late. World J Surg 20: 437–446

    Article  PubMed  CAS  Google Scholar 

  3. Opal SM (1995) Clinical trials of novel therapeutic agents: Why did they fail? In: Vincent JL (ed) Yearbook of Intensive Care and Emergency Medicine 1995, pp 425–436

    Chapter  Google Scholar 

  4. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239–257

    Article  PubMed  CAS  Google Scholar 

  5. Lee A, Whyte KB, Haslett C (1993) Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J Leukocyte Biol 54: 283–288

    PubMed  CAS  Google Scholar 

  6. Biffl WL, Moore EE, Moore FA, et al (1996) Interleukin-6 delays neutrophil apoptosis. Arch Surg 131: 24–30

    Article  PubMed  CAS  Google Scholar 

  7. Mangan DF, Wahl SM (1991) Differential regulation of human monocyte programmed cell death (apoptosis) by chemotactic factors and pro-inflammatory cytokines. J Immunol 147: 3408–3412

    PubMed  CAS  Google Scholar 

  8. Rogy MA, Oldenburg HSA, Coyle S, Trousdale R, Moldawer LL, Lowry SF (1996) Correlation between acute physiology and chronic health evaluation (APACHE III score) and immunological parameters in critically ill patients with sepsis. Brit J Surg 83: 396–400

    Article  PubMed  CAS  Google Scholar 

  9. Agosti JM, Fisher JC, Opal SM, et al (1994) Treatment of patients with sepsis syndrome with solube TNF receptor (sTNFR). Antimicrob Agents Chemother 65: M3 (Abst)

    Google Scholar 

  10. Fisher DJ, Agosti JM, Opal SM, Lowry SF, et al (1996) Treatment of septic shock with the tumor necrosis factor receptor: Fc fusion protein. N Engl J Med 334: 1697–1702

    Article  PubMed  CAS  Google Scholar 

  11. Savill J, Dransfield I, Hogg N, Haslett C (1990) Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 343: 170–176

    Article  PubMed  CAS  Google Scholar 

  12. Meagher LC, Savill JS, Baker A, et al (1992) Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2. J Leukocyte Biol 52: 269–273

    PubMed  CAS  Google Scholar 

  13. Squier MKT, Sehnert AJ, Cohen JJ (1995) Apoptosis in leukocytes. J Leukocyte Biol 57: 2–10

    PubMed  CAS  Google Scholar 

  14. Saville JS, Wyllie AH, Henson JE, et al (1989) Macrophage phagocytosis of aging neutrophils in inflammation: Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest 83: 865–875

    Article  Google Scholar 

  15. Van der Poll T, Lowry SF (1995) Tumor necrosis factor in sepsis: Mediator of multiple organ failure or essential part of host defense? Shock 3: 1–12

    PubMed  Google Scholar 

  16. Bazzoni F, Beutler B (1996) The tumor necrosis factor ligand and receptor families. N Engl J Med 334: 1717–1725

    Article  PubMed  CAS  Google Scholar 

  17. Tartaglia LA, Goeddel DV (1992) Two TNF receptors. Immunol Today 13: 151–153

    Article  PubMed  CAS  Google Scholar 

  18. Jarvis WD, Kolesnick RN, Fornari FA, Traylor RS, Gewirtz DA, Grant S (1994) Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc Natl Acad Sci USA 91: 73–77

    Article  PubMed  CAS  Google Scholar 

  19. MacEwan DJ (1996) Elevated cPLA2 levels as a mechanism by which the p70 TNF and p75 NGF receptors enhance apoptosis. FEBS Letters 379: 77–81

    Article  PubMed  CAS  Google Scholar 

  20. Vandenabeele P, Declercq W, Vanhaesbroeck B, et al (1995) Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells. J Immunol 154: 2904–2913

    PubMed  CAS  Google Scholar 

  21. Bigda J, Beletsky I, Brakebusch C, et al (1994) Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity. J Exp Med 180: 445–460

    Article  PubMed  CAS  Google Scholar 

  22. Suda T, Takahashi T, Golstein P, et al (1993) Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75: 1169–1178

    Article  PubMed  CAS  Google Scholar 

  23. Nagata S, Golstein P (1995) The Fas death factor. Science 267: 1449–1456

    Article  PubMed  CAS  Google Scholar 

  24. Fisher GH, Tosenberg FJ, Straus SE, et al (1995) Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81: 935–946

    Article  PubMed  CAS  Google Scholar 

  25. Boldin MP, Mett IL, Varfolomeev EE, et al (1995) Self-association of the “death domains” of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling of TNF and Fas/APO1 effects. J Biol Chem 20: 387–391

    Google Scholar 

  26. Chu K, Niu XH, Williams LT (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Nat Acad Sci USA 92: 11 894–11 898

    Google Scholar 

  27. Obeid LM, Linardic CM, Karolak LA, Hannun YA (1993) Programmed cell death induced by ceramide. Science 259: 1769–1771

    Article  PubMed  CAS  Google Scholar 

  28. Kolesnick R, Golde DW (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77: 325–328

    Article  PubMed  CAS  Google Scholar 

  29. Troiano L, Monti D, Cossarizza A, et al (1995) Involvement of CD45 in dexamethasone-and heat shock-induced apoptosis of rat thymocytes. Biochem Biophys Res Commun 214: 941–948

    Article  PubMed  CAS  Google Scholar 

  30. Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW (1996) In vivo antioxidant treatment suppresses nuclear factor-KB activation and neutrophilic lung inflammation. J Immunol 157:1630–1637

    Google Scholar 

  31. Siebenlist U, Granzoso G, Brown K (1994) Structure, regulation and function of NF-KB. Annu Rev Cell Biol 10: 405–412

    Article  PubMed  CAS  Google Scholar 

  32. Korsmeyer SJ (1992) Bd-2: An antidote to programmed cell death. Cancer Surveys 15:105–118

    Google Scholar 

  33. Memon SA, Moreno MB, Petrak D, Zacharchuk CM (1995) Bd-2 blocks glucocorticoid-but not Fas-or activation-induced apoptosis in a T cell hybridoma. J Immunol 155: 4644–4652

    Google Scholar 

  34. Bradbury D, Zhu YM, Russell N (1994) Regulation of bd-2 expression and apoptosis in acute myeloblastic leukemia cells by granulocyte-macrophage colony-stimulating factor. Leukemia 8: 776–779

    Google Scholar 

  35. Ivanov VN, Deng G, Podack ER, Malek TR (1995) Pleiotropic effects of bd-2 on transcription factors in T cells: Potential role of NF-x13 p50-p50 for the anti-apoptotic function of bd-2. Int Immunol 7: 1709–1720

    Article  PubMed  CAS  Google Scholar 

  36. Lagasse E, Weissman IL (1994) Bc1–2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med 179: 1047–1052

    Google Scholar 

  37. Van der Poll T, Galvano SE, Kumar A, et al (1995) Endotoxin induces downregulation of tumor necrosis factor receptors on circulating monocytes and granulocytes in humans. Blood 86: 2754–2759

    PubMed  Google Scholar 

  38. Calvano SE, van der Poll T, Coyle SM, et al (1996) Monocyte tumor necrosis factor receptor levels as a predictor of risk in human sepsis. Arch Surg 131: 434–437

    Article  PubMed  CAS  Google Scholar 

  39. Colotta F, Re F, Polentarutti N, Sozzani S, Mantovani A (1992) Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80: 2012–2020

    PubMed  CAS  Google Scholar 

  40. Mangan DF, Welch GR, Wahl SM (1991) Lipopolysaccharide, tumor necrosis factor-a, and IL-lß prevent programmed cell death (apoptosis) in human peripheral blood monocytes. J Immunol 146: 1541–1546

    PubMed  CAS  Google Scholar 

  41. Mangan DF, Robertson B, Wahl SM (1992) IL-4 enhances programmed cell death (apoptosis) in stimulated human monocytes. J Immunol 148: 1812–1816

    PubMed  CAS  Google Scholar 

  42. Fleischmann J, Golde DW, Weisbart RH, Gasson JC (1986) Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils. Blood 68: 708–711

    PubMed  CAS  Google Scholar 

  43. Lundblad R, Nesland JM, Giercksky KE (1996) Granulocyte colony-stimulating factor improves survival rate and reduces concentrations of bacteria, endotoxin, tumor necrosis factor, and endothelin-1 in fulminant intra-abdominal sepsis in rats. Grit Care Med 24: 820–826

    Article  CAS  Google Scholar 

  44. Wing EJ, Magee DM, Whiteside TL, Kaplan SS, Shadduck RK (1989) Recombinant human granulocyte/macrophage colony-stimulating factor enhances monocyte cytotoxicity and secretion of tumor necrosis factor-a and interferon in cancer patients. Blood 73: 643–646

    PubMed  CAS  Google Scholar 

  45. Williams MA, Kouroumoussis I, Syndercombe-Court D, et al (1995) Administration of recombinant human granulocyte-macrophage colony-stimulating factor after chemotherapy regulates the expression and secretion of monocyte tumor necrosis factor (TNF) and TNF receptors p55 and p75. Blood 86: 4234–4242

    PubMed  CAS  Google Scholar 

  46. Bach MK, Brashler JR (1995) Evidence that granulocyte/macrophage-colony-stimulating factor and interferon-y maintain the viability of human peripheral blood monocytes in part by their suppression of IL-10 production. Int Arch Allergy Immunol 107: 90–92

    Article  PubMed  CAS  Google Scholar 

  47. Watson RWG, Rotstein OD, Nathens AB, Dackiw APB, Marshall JC (1996) Thiol-mediated redox regulation of neutrophil apoptosis. Surgery 120: 150–158

    Article  PubMed  CAS  Google Scholar 

  48. Meduri GU, Headley S, Kohler G, et al (1995) Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Chest 107: 1062–1073

    Article  PubMed  CAS  Google Scholar 

  49. Steinberg KP, Milberg JA, Martin TR, Maunder RJ, Cockrill BA, Hudson LD (1994) Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. J Respir Crit Care Med 150: 113–122

    CAS  Google Scholar 

  50. Cox G, Crossley J, Xing Z (1995) Macrophage engulfment of apoptotic neutrophils contributes to the resolution of acute pulmonary inflammation in vivo. Am J Respir Cell Mol Biol 12: 232–237

    PubMed  CAS  Google Scholar 

  51. Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG, Wendel A (1995) Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models

    Google Scholar 

  52. Galle PR, Hofmann WJ, Walczak H (1995) Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage J Exp Med 11: 1223–1230

    Google Scholar 

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Authors
  1. E. Lin
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  2. S. E. Calvano
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  3. S. F. Lowry
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1997 Springer-Verlag Berlin Heidelberg

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Lin, E., Calvano, S.E., Lowry, S.F. (1997). Disordered Apoptosis as a Mechanism for Adverse Outcome. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1997. Yearbook of Intensive Care and Emergency Medicine, vol 1997. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13450-4_9

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  • DOI: https://doi.org/10.1007/978-3-662-13450-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-13452-8

  • Online ISBN: 978-3-662-13450-4

  • eBook Packages: Springer Book Archive

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