Abstract
Substance P (SP) is an important mediator of pro-inflammatory mechanisms in the skin. It targets multiple cells such as keratinocytes, mast cells, and fibroblasts which are involved in the cutaneous generation of pruritus. This suggests that SP is an interesting target for therapy. In fact, in recent case reports and case series, SP antagonists demonstrated a significant antipruritic effect in acute and chronic pruritus such as drug-induced pruritus, paraneoplastic pruritus, prurigo nodularis, cutaneous T-cell lymphoma, and brachioradial pruritus.
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Abbreviations
- ACE:
-
Angiotensin-converting enzyme
- AD:
-
Atopic dermatitis
- CGRP:
-
Calcitonin gene-related peptide
- CMH fibers:
-
Mechano- and heat-sensitive C-nerve fibers
- CMi fibers:
-
Mechano-insensitive C-nerve fibers
- CNS:
-
Central nervous system
- CP:
-
Chronic pruritus
- CRH:
-
Corticotropin-releasing hormone
- CRHR-1:
-
Corticotropin-releasing hormone receptor-1
- CRPS:
-
Complex regional pain syndrome
- DNFB:
-
Dinitrofluorobenzene
- H1:
-
Histamine-1 receptor
- IL:
-
Interleukin
- MC:
-
Mast cell
- NEP:
-
Neutral endopeptidase
- NGF:
-
Nerve growth factor
- NK1R:
-
Neurokinin-1 receptor
- NK2R:
-
Neurokinin-2 receptor
- NK3R:
-
Neurokinin-3 receptor
- NKA:
-
Neurokinin A
- NKB:
-
Neurokinin B
- NKγ:
-
Neuropeptide-γ
- NPK:
-
Neuropeptide K
- PN:
-
Prurigo nodularis
- PPTA:
-
Preprotachykinin-A
- SP:
-
Substance P
- TNF:
-
Tumor necrosis factor
- TRPV1:
-
Transient receptor potential vanilloid subtype 1
- VEGF:
-
Vascular endothelial growth factor
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Ständer, S., Luger, T.A. (2015). NK-1 Antagonists and Itch. In: Cowan, A., Yosipovitch, G. (eds) Pharmacology of Itch. Handbook of Experimental Pharmacology, vol 226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44605-8_14
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