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NK-1 Antagonists and Itch

  • Chapter
Pharmacology of Itch

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 226))

Abstract

Substance P (SP) is an important mediator of pro-inflammatory mechanisms in the skin. It targets multiple cells such as keratinocytes, mast cells, and fibroblasts which are involved in the cutaneous generation of pruritus. This suggests that SP is an interesting target for therapy. In fact, in recent case reports and case series, SP antagonists demonstrated a significant antipruritic effect in acute and chronic pruritus such as drug-induced pruritus, paraneoplastic pruritus, prurigo nodularis, cutaneous T-cell lymphoma, and brachioradial pruritus.

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Abbreviations

ACE:

Angiotensin-converting enzyme

AD:

Atopic dermatitis

CGRP:

Calcitonin gene-related peptide

CMH fibers:

Mechano- and heat-sensitive C-nerve fibers

CMi fibers:

Mechano-insensitive C-nerve fibers

CNS:

Central nervous system

CP:

Chronic pruritus

CRH:

Corticotropin-releasing hormone

CRHR-1:

Corticotropin-releasing hormone receptor-1

CRPS:

Complex regional pain syndrome

DNFB:

Dinitrofluorobenzene

H1:

Histamine-1 receptor

IL:

Interleukin

MC:

Mast cell

NEP:

Neutral endopeptidase

NGF:

Nerve growth factor

NK1R:

Neurokinin-1 receptor

NK2R:

Neurokinin-2 receptor

NK3R:

Neurokinin-3 receptor

NKA:

Neurokinin A

NKB:

Neurokinin B

NKγ:

Neuropeptide-γ

NPK:

Neuropeptide K

PN:

Prurigo nodularis

PPTA:

Preprotachykinin-A

SP:

Substance P

TNF:

Tumor necrosis factor

TRPV1:

Transient receptor potential vanilloid subtype 1

VEGF:

Vascular endothelial growth factor

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Author information

Authors and Affiliations

  1. Department of Dermatology, Competence Center Chronic Pruritus, University Hospital of Münster, Von-Esmarch-Strasse 58, 48149, Münster, Germany

    Sonja Ständer

  2. University Hospital of Münster, Von-Esmarch-Strasse 58, 48149, Münster, Germany

    Thomas A. Luger

Authors
  1. Sonja Ständer
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  2. Thomas A. Luger
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Correspondence to Sonja Ständer .

Editor information

Editors and Affiliations

  1. Department of Pharmacology Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Alan Cowan

  2. Department of Dermatology, Temple University School of Medicine, Philadephia, Pennsylvania, USA

    Gil Yosipovitch

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Ständer, S., Luger, T.A. (2015). NK-1 Antagonists and Itch. In: Cowan, A., Yosipovitch, G. (eds) Pharmacology of Itch. Handbook of Experimental Pharmacology, vol 226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44605-8_14

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